Adolescent Bisphenol-A exposure increases anxiety and impairs spatial memory and leads to enduring decreases in dendritic spine density in rats

2014 ◽  
Vol 43 ◽  
pp. 77
Author(s):  
R. Bowman
Keyword(s):  
Bisphenol A ◽  
Spatial Memory ◽  
Dendritic Spine ◽  
Spine Density ◽  
Dendritic Spine Density

"Bisphenol-A impairs memory and reduces dendritic spine density in adult male rats": Correction to Eilam-Stock et al. (2011).

2012 ◽  
Vol 126 (1) ◽  
pp. 195-195
Author(s):  
Tehila Eilam-Stock ◽  
Peter Serrano ◽  
Maya Frankfurt ◽  
Victoria Luine
Keyword(s):  
Bisphenol A ◽  
Adult Male ◽  
Dendritic Spine ◽  
Male Rats ◽  
Spine Density ◽  
Dendritic Spine Density

scholarly journals Bisphenol-A exposure during adolescence leads to enduring alterations in cognition and dendritic spine density in adult male and female rats

2015 ◽  
Vol 69 ◽  
pp. 89-97 ◽  
Author(s):  
Rachel E. Bowman ◽  
Victoria Luine ◽  
Samantha Diaz Weinstein ◽  
Hameda Khandaker ◽  
Sarah DeWolf ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Adult Male ◽  
Dendritic Spine ◽  
Female Rats ◽  
Spine Density ◽  
Male And Female ◽  
Dendritic Spine Density ◽  
Male And Female Rats

scholarly journals Bisphenol-A impairs memory and reduces dendritic spine density in adult male rats.

2012 ◽  
Vol 126 (1) ◽  
pp. 175-185 ◽  
Author(s):  
Tehila Eilam-Stock ◽  
Peter Serrano ◽  
Maya Frankfurt ◽  
Victoria Luine
Keyword(s):  
Bisphenol A ◽  
Adult Male ◽  
Dendritic Spine ◽  
Male Rats ◽  
Spine Density ◽  
Dendritic Spine Density

scholarly journals Age-Related Deficits in Spatial Memory and Hippocampal Spines in Virgin, Female Fischer 344 Rats

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Victoria N. Luine ◽  
Maureen E. Wallace ◽  
Maya Frankfurt
Keyword(s):  
Spatial Memory ◽  
Dendritic Spine ◽  
Pyramidal Neurons ◽  
Female Rats ◽  
Spine Density ◽  
Fischer 344 ◽  
Dendritic Spine Density ◽  
Basal Dendrites ◽  
Young Subjects ◽  
Aged Subjects

Effects of aging on memory and brain morphology were examined in aged, 21-month-old, and young, 4-month-old, Fischer 344 female rats. Spatial memory was assessed using the object placement task, and dendritic spine density was determined on pyramidal neurons in the hippocampus following Golgi impregnation. Consistent with previous studies, aged females showed poorer object placement performance than young subjects. Young subjects significantly discriminated the location of objects with a 1.5-hour intertrial delay while aged subjects did not. Spine density of basal dendrites on CA1 pyramidal cells was 16% lower in the aged subjects as compared to the young subjects. No differences in spine density were found between young and aged subjects in basal dendrites of CA1 or in either dendritic field of CA3 pyramidal neurons. Thus, decreased hippocampal CA1 dendritic spine density in aged rats may contribute to poorer spatial memory as compared to young rats. The possibility that the neuroplastic changes observed in this study may pertain only to female subjects having had a specific set of life experiences is discussed. Different factors, such as reproductive status, diet, and handling may contribute to neuroplasticity of the brain during aging; however, this view requires further examination.

scholarly journals Simultaneous Changes of Spatial Memory and Spine Density after Intrahippocampal Administration of Fibrillar Aβ1–42to the Rat Brain

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Emőke Borbély ◽  
János Horváth ◽  
Szabina Furdan ◽  
Zsolt Bozsó ◽  
Botond Penke ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Dendritic Spine ◽  
Density Measurement ◽  
Rat Hippocampus ◽  
Learning Ability ◽  
Spine Density ◽  
Ca1 Region ◽  
Dendritic Spine Density ◽  
Intrahippocampal Injection ◽  
The Brain

Several animal models of Alzheimer’s disease have been used in laboratory experiments. Intrahippocampal injection of fibrillar amyloid-beta (fAβ) peptide represents one of the most frequently used models, mimicking Aβdeposits in the brain. In our experiment synthetic fAβ1–42peptide was administered to rat hippocampus. The effect of the Aβpeptide on spatial memory and dendritic spine density was studied. The fAβ1–42-treated rats showed decreased spatial learning ability measured in Morris water maze (MWM). Simultaneously, fAβ1–42caused a significant reduction of the dendritic spine density in the rat hippocampus CA1 region. The decrease of learning ability and the loss of spine density were in good correlation. Our results prove that both methods (MWM and dendritic spine density measurement) are suitable for studying Aβ-triggered neurodegeneration processes.

scholarly journals Adolescent bisphenol-A exposure decreases dendritic spine density: Role of sex and age

Synapse ◽  
2014 ◽  
Vol 68 (11) ◽  
pp. 498-507 ◽  
Author(s):  
Rachel E. Bowman ◽  
Victoria Luine ◽  
Hameda Khandaker ◽  
Joseph J. Villafane ◽  
Maya Frankfurt
Keyword(s):  
Bisphenol A ◽  
Dendritic Spine ◽  
Spine Density ◽  
Dendritic Spine Density

scholarly journals FMRP regulates the subcellular distribution of cortical dendritic spine density in a non-cell-autonomous manner

2021 ◽  
pp. 105253
Author(s):  
Katherine M. Bland ◽  
Adam Aharon ◽  
Eden L. Widener ◽  
M. Irene Song ◽  
Zachary O. Casey ◽  
...  
Keyword(s):  
Dendritic Spine ◽  
Subcellular Distribution ◽  
Spine Density ◽  
Dendritic Spine Density
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