Rapid synthesis and in vitro and in vivo evaluation of folic acid derivatives labeled with fluorine-18 for PET imaging of folate receptor-positive tumors

2011 ◽  
Vol 38 (7) ◽  
pp. 1019-1028 ◽  
Author(s):  
I. Al Jammaz ◽  
B. Al-Otaibi ◽  
S. Amer ◽  
S.M. Okarvi
Keyword(s):  
Folic Acid ◽  
Pet Imaging ◽  
Folate Receptor ◽  
Rapid Synthesis ◽  
In Vivo Evaluation

Adriamycin Loaded and Folic Acid Coated Zn-MOF for Tumor-Targeted Chemotherapy of Cervical Cancer

2019 ◽  
Vol 9 (11) ◽  
pp. 1535-1541
Author(s):  
Jing Sun ◽  
Xiang-E Long ◽  
Rong Li ◽  
Chao-Feng Hu ◽  
Xiao-Hong Ge
Keyword(s):  
Folic Acid ◽  
Drug Targeting ◽  
Folate Receptor ◽  
Metal Organic Framework ◽  
Drug Carriers ◽  
Spherical Particles ◽  
Metal Organic ◽  
Cervical Tumors

The drug delivery systems (DDSs) introduced in recent years have been wide recognized to greatly evaluate the efficacy of drugs. With the aim to increase drug targeting to tumors as well as decrease the side effect of both drug and drug carriers, this study has developed a hybrid DDS by incorporation zinc based metal-organic framework (Zn-MOF) and folic acid (FA). Moreover, adriamycin (Adr) as a model anticancer drug was loaded into the FA/Zn-MOF nanoparticle. The as-prepared FA/ZnMOF/Adr was expected to serve as a tumor targeting DDS that capable of effectively delivering Adr to cervical tumors. Characterization revealed that FA/Zn-MOF/Adr was nanosized spherical particles with high stability and biocompatibility. Most importantly, the FA/Zn-MOF/Adr could realize positive targeting to FA overexpressed HeLa cells through folate receptor (FR). Therefore, FA/Zn-MOF/Adr resulted enhanced in vitro and in vivo anticancer benefits than than free Adr or FA unmodified Zn-MOF/Adr.

Novel folate-targeted docetaxel-loaded nanoparticles for tumour targeting: in vitro and in vivo evaluation

RSC Advances ◽  
2016 ◽  
Vol 6 (69) ◽  
pp. 64306-64314 ◽  
Author(s):  
M. H. Han ◽  
Z. T. Li ◽  
D. D. Bi ◽  
Y. F. Guo ◽  
H. X. Kuang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Folic Acid ◽  
Cancer Therapy ◽  
Targeted Delivery ◽  
Tumour Targeting ◽  
Breast Cancer Therapy ◽  
In Vivo Evaluation ◽  
Targeted Delivery System

Cholesterol-PEG1000-FA (folic acid) was synthesized as a stabilizer to encapsulate DTX, for the construction of a promising targeted delivery system for breast cancer therapy.

scholarly journals In Vitro and in Vivo Evaluation of 11C-Labeled Azetidinecarboxylates for Imaging Monoacylglycerol Lipase by PET Imaging Studies

2018 ◽  
Vol 61 (6) ◽  
pp. 2278-2291 ◽  
Author(s):  
Ran Cheng ◽  
Wakana Mori ◽  
Longle Ma ◽  
Mireille Alhouayek ◽  
Akiko Hatori ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Monoacylglycerol Lipase ◽  
Imaging Studies ◽  
In Vivo Evaluation

scholarly journals Transferrin conjugates of triazacyclononane-based bifunctional NE3TA chelates for PET imaging: Synthesis, Cu-64 radiolabeling, and in vitro and in vivo evaluation

2016 ◽  
Vol 154 ◽  
pp. 60-66 ◽  
Author(s):  
Chi Soo Kang ◽  
Ningjie Wu ◽  
Yunwei Chen ◽  
Xiang Sun ◽  
Nilantha Bandara ◽  
...  
Keyword(s):  
Pet Imaging ◽  
In Vivo Evaluation

Folate receptor-targeted multimodal polymersomes for delivery of quantum dots and doxorubicin to breast adenocarcinoma: In vitro and in vivo evaluation

2016 ◽  
Vol 500 (1-2) ◽  
pp. 162-178 ◽  
Author(s):  
Mona Alibolandi ◽  
Khalil Abnous ◽  
Fatemeh Sadeghi ◽  
Hossein Hosseinkhani ◽  
Mohammad Ramezani ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Folate Receptor ◽  
Breast Adenocarcinoma ◽  
In Vivo Evaluation

In Silico, in Vitro, and in Vivo Evaluation of New Candidates for α-Synuclein PET Imaging

2018 ◽  
Vol 15 (8) ◽  
pp. 3153-3166 ◽  
Author(s):  
Mathieu Verdurand ◽  
Elise Levigoureux ◽  
Wael Zeinyeh ◽  
Laurent Berthier ◽  
Meriem Mendjel-Herda ◽  
...  
Keyword(s):  
Pet Imaging ◽  
In Silico ◽  
In Vivo Evaluation

In Vitro and in Vivo Evaluation of an Innocuous Drug Cocktail To Improve the Quality of Folic Acid Targeted Nuclear Imaging in Preclinical Research

2013 ◽  
Vol 10 (3) ◽  
pp. 967-974 ◽  
Author(s):  
Cristina Müller ◽  
Josefine Reber ◽  
Claudia Schlup ◽  
Christopher P. Leamon ◽  
Roger Schibli
Keyword(s):  
Folic Acid ◽  
Nuclear Imaging ◽  
Drug Cocktail ◽  
Preclinical Research ◽  
In Vivo Evaluation
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