Efficacy of l-carnitine administration on fatigue, nutritional status, oxidative stress, and related quality of life in 12 advanced cancer patients undergoing anticancer therapy

Abstract Background: Patients suffering from advanced cancer often loose contact with their primary care physician (PCP) during oncologic treatment and palliative care is introduced very late.The aim of this pilot study was to test the feasibility and procedures for a randomized trial of an intervention to teach PCPs a palliative care approach and communication skills to improve advanced cancer patients’ quality of life. Methods: Observational pilot study in 5 steps. 1) Recruitment of PCPs. 2) Intervention: training on palliative care competencies and communication skills addressing end-of-life issues.3) Recruitment of advanced cancer patients by PCPs. 4) Patients follow-up by PCPs, and assessment of their quality of life by a research assistant 5) Feedback from PCPs using a semi-structured focus group and three individual interviews with qualitative deductive theme analysis.Results: 8 PCPs were trained. PCPs failed to recruit patients for fear of imposing additional loads on their patients. PCPs changed their approach of advanced cancer patients. They became more conscious of their role and responsibility during oncologic treatments and felt empowered to take a more active role picking up patient’s cues and addressing advance directives. They developed interprofessional collaborations for advance care planning. Overall, they discovered the role to help patients to make decisions for a better end-of-life.Conclusions: PCPs failed to recruit advanced cancer patients, but reported a change in paradigm about palliative care. They moved from a focus on helping patients to die better, to a new role helping patients to define the conditions for a better end-of-life.Trial registration : The ethics committee of the canton of Geneva approved the study (2018-00077 Pilot Study) in accordance with the Declaration of Helsinki

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Quality of life domains important and relevant to family caregivers of advanced cancer patients in an Asian population: a qualitative study

Quality of Life Research ◽

10.1007/s11136-014-0832-3 ◽

2014 ◽

Vol 24 (4) ◽

pp. 817-828 ◽

Cited By ~ 10

Author(s):

Geok Ling Lee ◽

Mandy Yen Ling Ow ◽

Ramaswamy Akhileswaran ◽

Grace Su Yin Pang ◽

Gilbert Kam Tong Fan ◽

...

Keyword(s):

Quality Of Life ◽

Qualitative Study ◽

Cancer Patients ◽

Family Caregivers ◽

Advanced Cancer ◽

Asian Population ◽

Life Domains ◽

Advanced Cancer Patients

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Validation of the “Quality of Life in Life-Threatening Illness—Family Carer Version” (QOLLTI-F) in German-speaking carers of advanced cancer patients

Supportive Care in Cancer ◽

10.1007/s00520-014-2272-6 ◽

2014 ◽

Vol 22 (10) ◽

pp. 2783-2791 ◽

Cited By ~ 7

Author(s):

Sophie Schur ◽

Alexandra Ebert-Vogel ◽

Michaela Amering ◽

Eva Katharina Masel ◽

Marie Neubauer ◽

...

Keyword(s):

Quality Of Life ◽

Cancer Patients ◽

Advanced Cancer ◽

Family Carer ◽

Advanced Cancer Patients ◽

Life Threatening Illness ◽

German Speaking ◽

Life Threatening

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Chemotherapy use and quality of life in cancer patients at the end of life: an integrative review

Health and Quality of Life Outcomes ◽

10.1186/s12955-020-01580-0 ◽

2020 ◽

Vol 18 (1) ◽

Author(s):

Elham Akhlaghi ◽

Rebecca H. Lehto ◽

Mohsen Torabikhah ◽

Hamid Sharif Nia ◽

Ahmad Taheri ◽

...

Keyword(s):

Quality Of Life ◽

Palliative Care ◽

End Of Life ◽

Cancer Patients ◽

Advanced Cancer ◽

Palliative Chemotherapy ◽

Palliative Therapy ◽

Related Quality ◽

Health Related

Abstract Background When curative treatments are no longer available for cancer patients, the aim of treatment is palliative. The emphasis of palliative care is on optimizing quality of life and provided support for patients nearing end of life. However, chemotherapy is often offered as a palliative therapy for patients with advanced cancer nearing death. The purpose of this review was to evaluate the state of the science relative to use of palliative chemotherapy and maintenance of quality of life in patients with advanced cancer who were at end of life. Materials and methods Published research from January 2010 to December 2019 was reviewed using PRISMA guidelines using PubMed, Proquest, ISI web of science, Science Direct, and Scopus databases. MeSH keywords including quality of life, health related quality of life, cancer chemotherapy, drug therapy, end of life care, palliative care, palliative therapy, and palliative treatment. Findings 13 studies were evaluated based on inclusion criteria. Most of these studies identified that reduced quality of life was associated with receipt of palliative chemotherapy in patients with advanced cancer at the end of life. Conclusion Studies have primarily been conducted in European and American countries. Cultural background of patients may impact quality of life at end of life. More research is needed in developing countries including Mideastern and Asian countries.

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