Oral cavity and oropharynx squamous cell carcinoma with metastasis to the parotid lymph nodes

Objective 1) The primary goal of this study was to evaluate the incidence of radionecrosis among patients treated with radiation therapy for oral cavity & oropharynx squamous cell carcinoma at our institution. Many patients with oral cavity & oropharyngeal cancers receive radiation to preserve the tongue, knowing the risks of post-treatment radionecrosis. However, recent protocols have intensified chemo-radiotherapy in an effort to improve local control while possibly increasing risk. 2) Among those patients with radionecrosis, we also analyzed their cancer treatment regimen, associated risk factors, the severity of the radionecrosis and the resulting treatment they recieved. Methods We performed a retrospective review of all adult patients at our tertiary care facility with biopsy proven squamous cell carcinoma of the oral cavity & oropharynx from 1999 to 2007 who completed a full course of radiotherapy at our facility with at least 6 months follow-up. Medical charts were reviewed for the presence of radionecrosis as well as for other corresponding, pertinent data. Results After reviewing 241 patients, a total of 107 patients were included. 5 of 65 with oropharynx disease had radionecrosis, revealing an incidence of 7.7%. Among the oral cavity group there were 8 out of 42 patients with radionecrosis, revealing an incidence of 19%. The overall incidence among our treatment group was 12.1%. Conclusions Radiation-induced necrosis of the oral cavity & oropharynx is still a significant complication in the treatment of head and neck cancer and poses a higher risk in the oral cavity than the oropharynx.

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Influence of Pathological Nodal Status and Maximal Standardized Uptake Value of the Primary Tumor and Regional Lymph Nodes on Treatment Plans in Patients With Advanced Oral Cavity Squamous Cell Carcinoma

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2009.05.002 ◽

2010 ◽

Vol 77 (2) ◽

pp. 421-429 ◽

Cited By ~ 23

Author(s):

Chun-Ta Liao ◽

Hung-Ming Wang ◽

Joseph Tung-Chieh Chang ◽

Chien-Yu Lin ◽

Shu-Hang Ng ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Cavity ◽

Lymph Nodes ◽

Cell Carcinoma ◽

Squamous Cell ◽

Primary Tumor ◽

Standardized Uptake Value ◽

Regional Lymph Nodes ◽

Treatment Plans ◽

Maximal Standardized Uptake Value

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Metastases to Supramandibular Facial Lymph Nodes in Patients With Squamous Cell Carcinoma of the Oral Cavity

Journal of Oral and Maxillofacial Surgery ◽

10.1016/j.joms.2008.12.025 ◽

2009 ◽

Vol 67 (7) ◽

pp. 1401-1408 ◽

Cited By ~ 7

Author(s):

Vassilis Petsinis ◽

Nikolaos Papadogeorgakis ◽

Ioulia Evangelou ◽

Lampros Goutzanis ◽

Ekaterini Pandelidaki ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Cavity ◽

Lymph Nodes ◽

Cell Carcinoma ◽

Squamous Cell

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Expression of stem cell-regulating miRNAs in oral cavity and oropharynx squamous cell carcinoma

Journal of Oral Pathology and Medicine ◽

10.1111/jop.12424 ◽

2016 ◽

Vol 45 (9) ◽

pp. 647-654 ◽

Cited By ~ 12

Author(s):

Bárbara de Lima Brito ◽

Silvia Vanessa Lourenço ◽

Aline Santos Damascena ◽

Luiz Paulo Kowalski ◽

Fernando Augusto Soares ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Stem Cell ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Oropharynx Squamous Cell Carcinoma

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Ultrasonography and computed tomography of extracapsular invasion in cervical lymph nodes of squamous cell carcinoma in the oral cavity

Journal of Medical Ultrasonics ◽

10.1007/s10396-004-0010-2 ◽

2004 ◽

Vol 31 (2) ◽

Cited By ~ 1

Author(s):

Junichi Ishii ◽

Hirokazu Nagasawa ◽

Masashi Yamane ◽

Hitoshi Ishikawa ◽

Masashi Yamashiro ◽

...

Keyword(s):

Computed Tomography ◽

Squamous Cell Carcinoma ◽

Oral Cavity ◽

Lymph Nodes ◽

Cell Carcinoma ◽

Squamous Cell ◽

Cervical Lymph Nodes ◽

Extracapsular Invasion

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Frequency of metastasis to posterior triangle and lower deep jugular lymph nodes in patients with squamous cell carcinoma of oral cavity having clinically N1 neck

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20193871 ◽

2019 ◽

Vol 5 (5) ◽

pp. 1286

Author(s):

Shilpa Varchasvi ◽

Azeem Moyihuddin

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Oral Cavity ◽

Lymph Nodes ◽

Prospective Study ◽

Cell Carcinoma ◽

Squamous Cell ◽

Buccal Mucosa ◽

Research Centre ◽

Posterior Triangle

Background: Oral cancer is the sixth most common cancer in the world and is largely preventable. The objective of the study is to find out the frequency of metastasis to posterior triangle lymph nodes and lower deep jugular (supraclavicular) lymph nodes in patients with squamous cell carcinoma of oral cavity having clinically N1 neck.Methods: A hospital based prospective study. This prospective study was conducted in R. L. Jalappa Hospital and Research Centre and SDU Medical College Kolar, Karnataka. 30 patients having oral squamous cell carcinoma with clinically N1 neck (single ipsilateral lymph node less than 3cms in diameter) undergoing modified radical neck dissection in R. L. Jalappa Hospital and Research Centre. Results: In our study, 4 were male (13%) and 26 were females (87%). The age of the patients ranged from 41-70 years with a mean age of 53 years. Majority of primary tumours were buccal mucosa tumours (24). We had 6 anterior 2/3rd tongue tumours. The primary tumour staging included 17 T2 lesions (57%), 3 T3 lesions (10%), 10 T4 lesions (33%) in patients with buccal mucosa carcinoma, fourteen patients had T2 disease, 9 patients had T4 and one patient had T3 disease.Conclusions: Most common nodal involvement in buccal mucosa carcinoma was level Ib (submandibular lymph node). The incidence of level IV (supraclavicular) and level V (posterior triangle) lymph node metastasis is low in buccal mucosa carcinoma patients with clinically N1 neck.

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