Lymphosonographic Sentinel node Biopsy of the Supraglottis in a Swine Model

2008 ◽  
Vol 139 (6) ◽  
pp. 798-804 ◽  
Author(s):  
Joseph M. Curry ◽  
Christopher R. Grindle ◽  
Daniel A. Merton ◽  
Barry B. Goldberg ◽  
David Rosen ◽  
...  
Keyword(s):  
Sentinel Node ◽  
Sentinel Node Biopsy ◽  
Porcine Model ◽  
Ultrasound Contrast Agent ◽  
Blue Dye ◽  
Swine Model ◽  
Node Biopsy ◽  
Contrast Enhanced ◽  
Novel Method

Objective To test the feasibility of a novel contrast-enhanced ultrasound (CEUS) technique, or lymphosonography, for sentinel node biopsy (SNB) of the supraglottis in a porcine model. Study Design and Setting In this prospective, non-randomized animal study, blue dye and ultrasound contrast agent were injected into the supraglottis in seven 50-kg Yorkshire swine. Transcutaneous CEUS was used to identify real-time lymphatic flow of contrast through lymph channels (LC) to the sentinel lymph node (SLN). SNB was carried out, visually identifying a blue node, with the assistance of intraoperative CEUS. Bilateral modified radical neck dissections were performed to search for any residual contrast-positive or blue SLNs. Results In each case, at least one SLN was identified by preoperative CEUS. A total of 12 nodes were identified on preoperative CEUS, and 11 of 12 nodes were stained with blue dye (91.7%). No residual blue or contrast-positive nodes were identified on neck dissection. Conclusions Lymphosonographic SNB of the supraglottis in a porcine model is technically feasible, and yields results comparable to traditional blue dye–guided techniques. No “shine-through” effect or nonsequential nodal enhancement occurred. This technique holds promise for sentinel node biopsy and allows a novel method for in vivo investigation of the lymphatic system.

scholarly journals Thyroid Lymphosonography: A Novel Method for Evaluating Lymphatic Drainage

2009 ◽  
Vol 118 (9) ◽  
pp. 645-650 ◽  
Author(s):  
Joseph M. Curry ◽  
Waleed H. Ezzat ◽  
Daniel A. Merton ◽  
Barry B. Goldberg ◽  
David M. Cognetti ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Sentinel Node ◽  
Sentinel Node Biopsy ◽  
Lymphatic Drainage ◽  
Blue Dye ◽  
Lymphatic Channel ◽  
Superior Mediastinum ◽  
Mediastinal Dissection ◽  
Node Biopsy ◽  
Contrast Enhanced

Objectives: We evaluated lymphosonography, or contrast-enhanced, ultrasonography (US)–guided sentinel lymph node (SLN) detection, as a technique for demonstrating the lymphatic drainage of the thyroid gland. Methods: In this prospective animal study, four 50-kg Yorkshire swine underwent transcutaneous injection of a US contrast agent and methylene blue dye into the thyroid gland. Contrast-enhanced US was used to identify draining lymphatic channels and SLNs. Sentinel node biopsy was conducted. Subsequently, bilateral neck and upper mediastinal dissection was carried out. Results: In 3 of 4 cases, a blue dye–positive and US contrast–positive SLN was identified. We identified SLNs in level IV in 2 cases. One case revealed 2 adjacent nodes in the superior mediastinum. In 1 case, a lymphatic channel was identified traveling into the mediastinum, but exposure of the SLN could not be obtained. No residual blue dye–positive or US contrast–positive nodes were identified on subsequent dissection. Conclusions: Lymphosonography of the thyroid gland in a porcine model correlates well with blue dye–guided sentinel node biopsy and is technically feasible, although in some cases access to the SLN may be difficult. This technique could potentially enable a detailed analysis of thyroidal lymphatic drainage if applied to humans.

Ultrasound-guided contrast-enhanced sentinel node biopsy of the head and neck in a porcine model

2007 ◽  
Vol 137 (5) ◽  
pp. 735-741 ◽  
Author(s):  
Joseph M. Curry ◽  
Esa Bloedon ◽  
Kelly M. Malloy ◽  
David M. Cognetti ◽  
Daniel A. Merton ◽  
...  
Keyword(s):  
Sentinel Node ◽  
Head And Neck ◽  
Sentinel Node Biopsy ◽  
Porcine Model ◽  
Ultrasound Guided ◽  
Node Biopsy ◽  
Contrast Enhanced

10:20: Ultrasound-Guided Sentinel Node Biopsy in a Porcine Model

2007 ◽  
Vol 137 (2_suppl) ◽  
pp. P77-P77
Author(s):  
Michael E. Kupferman ◽  
John S. Rhee ◽  
Joseph Curry ◽  
Esa Alohilani Bloedon ◽  
David Rosen ◽  
...  
Keyword(s):  
Sentinel Node ◽  
Sentinel Node Biopsy ◽  
Porcine Model ◽  
Ultrasound Guided ◽  
Node Biopsy

scholarly journals Added value of blue dye injection in sentinel node biopsy of breast cancer patients: Do all patients need blue dye?

2014 ◽  
Vol 12 (4) ◽  
pp. 325-328 ◽  
Author(s):  
Ramin Sadeghi ◽  
Ghazaleh Alesheikh ◽  
Seyed Rasoul Zakavi ◽  
Asiehsadat Fattahi ◽  
Abbas Abdollahi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Sentinel Node ◽  
Cancer Patients ◽  
Sentinel Node Biopsy ◽  
Added Value ◽  
Blue Dye ◽  
Breast Cancer Patients ◽  
Node Biopsy

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy

10.3791/57201 ◽  
2019 ◽  
Author(s):  
Bayu Brahma ◽  
Rizky I. Putri ◽  
Lenny Sari ◽  
Ramadhan Karsono ◽  
Denni J. Purwanto ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Methylene Blue ◽  
Sentinel Node ◽  
Sentinel Node Biopsy ◽  
Blue Dye ◽  
Methylene Blue Dye ◽  
Node Biopsy ◽  
Single Technique

Sentinel node biopsy in melanoma patients: The role of day surgery and local anaesthetic approach for quality-of-life and effective cost reduction.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e19002-e19002
Author(s):  
Fabio Ricci ◽  
Erminio Saralli ◽  
Loreto Giovanni Capuano ◽  
Maurizio Dorkin ◽  
Mario Valleriani ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Sentinel Node ◽  
Sentinel Node Biopsy ◽  
Cost Reduction ◽  
Primary Melanoma ◽  
Day Surgery ◽  
Blue Dye ◽  
Node Biopsy ◽  
Melanoma Patients

e19002 Background: Sentinel node biopsy (SNB) is used in the management of melanoma patients without nodal metastases. Methods: From January 1, 1998 to December 31, 2011 we performed 182 SNBs at St. M. Goretti Hospital. Patients presented a primary melanoma, Breslow thickness equal to or higher than 1 mm, lower than 1 mm with regression and/or ulceration, and/or IV-V Clark level, and/or mitotic rate ≥ 1/mm2, according to the 7th edition melanoma staging system. All patients underwent pre-operative lymphoscintigraphy with intradermal injection of 50-70 MBq 99 mTc colloidal albumina particles, 50-80 nm size range, in 0.1-0.2 ml saline solution. We never used blue dye. All patients underwent surgical treatment 4-12 h. later. We performed SNB in day-surgery (DS) under local anaesthesia (LA). Surgery incision was 3-4 cm. This study was approved by an ethics committee, discussed with all patients and informed consent was obtained. Purpose of the study is to investigate the validity of this approach for quality of life and cost reduction. Results: 165 patients underwent SNB, 64 (38.7%) in the inguinal region, 83 (50.3%) in axilla, 1 (0.6%) in the popliteal region, 4 (2.4%) patients showed inguinal bilateral sentinel lymph-node (SLN), 6 (3.6%) axillary bilateral SLN, 4 (2.4%) axillary and 3 (1.8%) inguinal double SLN. The SLN identification rate was 100%. After surgery we distributed a questionnaire to the patients about the acceptability of this approach. In 32 patients SLN was positive. In these patients we performed radical lymphoadenectomy, 12 (37.5%) inguinal and 20 (62.5%) axillary. Conclusions: The results achieved are extremely accurate. This procedure is safe, well accepted by patients (98%), reported better quality of life. The oncological results are absolutely reliable. As regards hospital logistics, operations in DS and LA can be easily managed, leading to a significant cost reduction, 42.15% less expensive than the same operation performed under general anaesthesia.

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