Activation of extracellular signal-regulated protein kinase in dorsal horn neurons in the rat neuropathic intermittent claudication model

Pain ◽  
2004 ◽  
Vol 109 (1) ◽  
pp. 64-72 ◽  
Author(s):  
Yi Liu ◽  
Koichi Obata ◽  
Hiroki Yamanaka ◽  
Yi Dai ◽  
Tetsuo Fukuoka ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Dorsal Horn ◽  
Intermittent Claudication ◽  
Dorsal Horn Neurons ◽  
Extracellular Signal

ERK Integrates PKA and PKC Signaling in Superficial Dorsal Horn Neurons. I. Modulation of A-Type K+ Currents

2003 ◽  
Vol 90 (3) ◽  
pp. 1671-1679 ◽  
Author(s):  
Hui-Juan Hu ◽  
Kathi S. Glauner ◽  
Robert W. Gereau
Keyword(s):  
Protein Kinase ◽  
Dorsal Horn ◽  
Neuronal Excitability ◽  
Potassium Currents ◽  
Superficial Dorsal Horn ◽  
Dorsal Horn Neurons ◽  
Kinase C ◽  
Extracellular Signal ◽  
Whole Cell Recordings ◽  
K Currents

The transient outward potassium currents (also known as A-type currents or IA) are important determinants of neuronal excitability. In the brain, IA is modulated by protein kinase C (PKC), protein kinase A (PKA), and extracellular signal-related kinase (ERK), three kinases that have been shown to be critical modulators of nociception. We wanted to determine the effects of these kinases on IA in superficial dorsal horn neurons. Using whole cell recordings from cultured mouse spinal cord superficial dorsal horn neurons, we found that PKC and PKA both inhibit IA in these cells, and that PKC has a tonic inhibitory action on IA. Further, we provide evidence supporting the hypothesis that PKC and PKA do not modulate IA directly, but rather act as upstream activators of ERKs, which modulate IA. These results suggest that ERKs serve as signal integrators in modulation of IA in dorsal horn neurons and that modulation of A-type potassium currents may underlie aspects of central sensitization mediated by PKC, PKA, and ERKs.

scholarly journals The mitogen and stress-activated protein kinase 1 regulates the rapid epigenetic tagging of dorsal horn neurons and nocifensive behaviour

Pain ◽  
2016 ◽  
Vol 157 (11) ◽  
pp. 2594-2604 ◽  
Author(s):  
Keri K. Tochiki ◽  
Maria Maiarú ◽  
Caspar Norris ◽  
Stephen P. Hunt ◽  
Sandrine M. Géranton
Keyword(s):  
Protein Kinase ◽  
Dorsal Horn ◽  
Dorsal Horn Neurons

Calcium/calmodulin-dependent protein kinase II in dorsal horn neurons in long-term diabetes

Neuroreport ◽  
2013 ◽  
Vol 24 (17) ◽  
pp. 992-996 ◽  
Author(s):  
Matija Boric ◽  
Antonia Jelicic Kadic ◽  
Lejla Ferhatovic ◽  
Damir Sapunar ◽  
Livia Puljak
Keyword(s):  
Protein Kinase ◽  
Dorsal Horn ◽  
Dependent Protein Kinase ◽  
Dorsal Horn Neurons ◽  
Calcium Calmodulin Dependent ◽  
Protein Kinase Ii ◽  
Dependent Protein

Activation of dorsal horn microglia contributes to diabetes-induced tactile allodynia via extracellular signal-regulated protein kinase signaling

Glia ◽  
2008 ◽  
Vol 56 (4) ◽  
pp. 378-386 ◽  
Author(s):  
Makoto Tsuda ◽  
Hikaru Ueno ◽  
Ayako Kataoka ◽  
Hidetoshi Tozaki-Saitoh ◽  
Kazuhide Inoue
Keyword(s):  
Protein Kinase ◽  
Dorsal Horn ◽  
Tactile Allodynia ◽  
Kinase Signaling ◽  
Extracellular Signal ◽  
Protein Kinase Signaling
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