Longitudinal evaluations of somatosensory-motor inhibition in Dopa-responsive dystonia

Author(s):  
Anne Weissbach ◽  
Annika Steinmeier ◽  
Martje Pauly ◽  
Duha M. Al-Shorafat ◽  
Gerard Saranza ◽  
...  
Keyword(s):  
Author(s):  
Martina Montalti ◽  
Marta Calbi ◽  
Valentina Cuccio ◽  
Maria Alessandra Umiltà ◽  
Vittorio Gallese

AbstractIn the last decades, the embodied approach to cognition and language gained momentum in the scientific debate, leading to evidence in different aspects of language processing. However, while the bodily grounding of concrete concepts seems to be relatively not controversial, abstract aspects, like the negation logical operator, are still today one of the main challenges for this research paradigm. In this framework, the present study has a twofold aim: (1) to assess whether mechanisms for motor inhibition underpin the processing of sentential negation, thus, providing evidence for a bodily grounding of this logic operator, (2) to determine whether the Stop-Signal Task, which has been used to investigate motor inhibition, could represent a good tool to explore this issue. Twenty-three participants were recruited in this experiment. Ten hand-action-related sentences, both in affirmative and negative polarity, were presented on a screen. Participants were instructed to respond as quickly and accurately as possible to the direction of the Go Stimulus (an arrow) and to withhold their response when they heard a sound following the arrow. This paradigm allows estimating the Stop Signal Reaction Time (SSRT), a covert reaction time underlying the inhibitory process. Our results show that the SSRT measured after reading negative sentences are longer than after reading affirmative ones, highlighting the recruitment of inhibitory mechanisms while processing negative sentences. Furthermore, our methodological considerations suggest that the Stop-Signal Task is a good paradigm to assess motor inhibition’s role in the processing of sentence negation.


Author(s):  
George P. Prigatano ◽  
Sandro Barbosa de Oliveira ◽  
Carlos Wellington Passos Goncalves ◽  
Sheila Marques Denucci ◽  
Roberta Monteiro Pereira ◽  
...  

Abstract Objective: Selective motor inhibition is known to decline with age. The purpose of this study was to determine the frequency of failures at inhibitory control of adjacent finger movements while performing a repetitive finger tapping task in young, middle-aged and older adults. Potential education and sex effects were also evaluated. Methods: Kinematic recordings of adjacent finger movements were obtained on 107 healthy adults (ages 20–80) while they performed a modified version of the Halstead Finger Tapping Test (HTFF). Study participants were instructed to inhibit all finger movements while tapping with the index finger. Results: Inability to inhibit adjacent finger movements while performing the task was infrequent in young adults (2.9% of individuals between 20 and 39 years of age) but increased with age (23.3% between the ages of 40 and 59; 31.0% between ages 60 and 80). Females and males did not differ in their inability to inhibit adjacent finger movements, but individuals with a college education showed a lower frequency of failure to inhibit adjacent finger movements (10.3%) compared to those with a high school education (28.6%). These findings were statistically significant only for the dominant hand. Conclusion: Selective motor inhibition failures are most common in the dominant hand and occur primarily in older healthy adults while performing the modified version of the HFTT. Monitoring selective motor inhibition failures may have diagnostic significance.


Author(s):  
Janina Rebecca Marchner ◽  
Claudia Preuschhof

AbstractStimuli that predict a rewarding outcome can cause difficulties to inhibit unfavourable behaviour. Research suggests that this is also the case for stimuli with a history of reward extending these effects on action control to situations, where reward is no longer accessible. We expand this line of research by investigating if previously reward-predictive stimuli promote behavioural activation and impair motor inhibition in a second unrelated task. In two experiments participants were trained to associate colours with a monetary reward or neutral feedback. Afterwards participants performed a cued go/no-go task, where cues appeared in the colours previously associated with feedback during training. In both experiments training resulted in faster responses in rewarded trials providing evidence of a value-driven response bias as long as reward was accessible. However, stimuli with a history of reward did not interfere with goal-directed action and inhibition in a subsequent task after removal of the reward incentives. While the first experiment was not conclusive regarding an impact of reward-associated cues on response inhibition, the second experiment, validated by Bayesian statistics, clearly questioned an effect of reward history on inhibitory control. This stands in contrast to earlier findings suggesting that the effect of reward history on subsequent action control is not as consistent as previously assumed. Our results show that participants are able to overcome influences from Pavlovian learning in a simple inhibition task. We discuss our findings with respect to features of the experimental design which may help or complicate overcoming behavioural biases induced by reward history.


2008 ◽  
Vol 119 ◽  
pp. S30
Author(s):  
Buchmann Johannes ◽  
Gierow Wolfgang ◽  
Weber Simone ◽  
Klauer Thomas ◽  
Wolters Alexander ◽  
...  

2004 ◽  
Vol 41 (2) ◽  
pp. 254-258 ◽  
Author(s):  
Sebastiaan Overeem ◽  
Walter Taal ◽  
E. Ocal Gezici ◽  
Gert Jan Lammers ◽  
J. Gert van Dijk
Keyword(s):  

2018 ◽  
Vol 33 (11) ◽  
pp. 1800-1804 ◽  
Author(s):  
Max-Philipp Stenner ◽  
Charlotte Baumgaertel ◽  
Hans-Jochen Heinze ◽  
Christos Ganos ◽  
Kirsten R. Müller-Vahl

1988 ◽  
Vol 254 (6) ◽  
pp. G802-G807 ◽  
Author(s):  
M. Gue ◽  
C. Honde ◽  
X. Pascaud ◽  
J. L. Junien ◽  
M. Alvinerie ◽  
...  

The influence of the kappa-opioid substances dynorphin-(1-13), ethylketocyclazocine (EKC), and U 50488 and mu-opioid substance [D-Ala2-N-Me, p-nitro-Phe4-Gly5-ol]enkephalin (DAGO) on gastric motor inhibition induced by acoustic stress (AS) was investigated in fasted dogs with strain-gauge transducers chronically implanted on the antrum and proximal jejunum. AS induced by 1 h of music (80-90 dB) was delivered through earphones. Starting 40-50 min after the last migrating motor complex (MMC), AS delayed by 114% the occurrence of the next gastric MMC, whereas intestinal motility was unaffected. During AS plasma cortisol increased (P less than 0.05) by 215%, 15 min after the beginning of noise and reached a peak at 30 min. When administered intracerebroventricularly at doses higher than 20 ng/kg, dynorphin abolished the AS-induced lengthening of the gastric MMC cycle. Similar blockade was observed for EKC and U 50488 at doses of 10 and/or 20 ng/kg, but DAGO was unable to affect the AS-induced gastric inhibition at any dosage tested (20-200 ng/kg icv). At doses effective against AS-induced hypomotility, both dynorphin-(1-13) and EKC reduced significantly (P less than or equal to 0.05) the associated maximal increase in plasma cortisol level. Plasma cortisol was unmodified by intracerebroventricular administration of DAGO. None of the agonists affected basal plasma cortisol levels or the increase (0-90 min) in response to intravenous adrenocorticotropic hormone (ACTH, 5 IU). Both EKC (50 ng/kg) and U 50488 (20 ng/kg) were unable to antagonize the inhibitory effect of ovine corticotropin-releasing factor (CRF, 100 ng/kg icv).(ABSTRACT TRUNCATED AT 250 WORDS)


1929 ◽  
Vol 86 (1) ◽  
pp. 79-112 ◽  
Author(s):  
Eleanora B. Saunders ◽  
Schachne Isaacs

Sign in / Sign up

Export Citation Format

Share Document