In silico assessment of kinetics and state dependent binding properties of drugs causing acquired LQTS

2016 ◽  
Vol 120 (1-3) ◽  
pp. 89-99 ◽  
Author(s):  
William Lee ◽  
Stefan A. Mann ◽  
Monique J. Windley ◽  
Mohammad S. Imtiaz ◽  
Jamie I. Vandenberg ◽  
...  
Keyword(s):  
In Silico ◽  
Binding Properties ◽  
State Dependent

scholarly journals Apicortin, a Constituent of Apicomplexan Conoid/Apical Complex and Its Tentative Role in Pathogen—Host Interaction

2021 ◽  
Vol 6 (3) ◽  
pp. 118
Author(s):  
Ferenc Orosz
Keyword(s):  
Plasmodium Falciparum ◽  
Toxoplasma Gondii ◽  
Therapeutic Target ◽  
In Silico ◽  
Free Living ◽  
Binding Properties ◽  
Host Interactions ◽  
Trichoplax Adhaerens ◽  
Host Interaction ◽  
Apical Complex

In 2009, apicortin was identified in silico as a characteristic protein of apicomplexans that also occurs in the placozoa, Trichoplax adhaerens. Since then, it has been found that apicortin also occurs in free-living cousins of apicomplexans (chromerids) and in flagellated fungi. It contains a partial p25-α domain and a doublecortin (DCX) domain, both of which have tubulin/microtubule binding properties. Apicortin has been studied experimentally in two very important apicomplexan pathogens, Toxoplasma gondii and Plasmodium falciparum. It is localized in the apical complex in both parasites. In T. gondii, apicortin plays a key role in shaping the structure of a special tubulin polymer, conoid. In both parasites, its absence or downregulation has been shown to impair pathogen–host interactions. Based on these facts, it has been suggested as a therapeutic target for treatment of malaria and toxoplasmosis.

scholarly journals Oxidation-State-Dependent Binding Properties of the Active Site in a Mo-Containing Formate Dehydrogenase

2017 ◽  
Vol 139 (29) ◽  
pp. 9927-9936 ◽  
Author(s):  
William E. Robinson ◽  
Arnau Bassegoda ◽  
Erwin Reisner ◽  
Judy Hirst
Keyword(s):  
Oxidation State ◽  
Active Site ◽  
Formate Dehydrogenase ◽  
Binding Properties ◽  
State Dependent

Discovery of a Novel Selective PPARγ Ligand with Partial Agonist Binding Properties by Integrated in Silico/in Vitro Work Flow

2013 ◽  
Vol 53 (4) ◽  
pp. 923-937 ◽  
Author(s):  
Irene Kouskoumvekaki ◽  
Rasmus K. Petersen ◽  
Filip Fratev ◽  
Olivier Taboureau ◽  
Thomas E. Nielsen ◽  
...  
Keyword(s):  
In Silico ◽  
Partial Agonist ◽  
Work Flow ◽  
Agonist Binding ◽  
Binding Properties

scholarly journals In silico analysis of the cyanobacterial lectin scytovirin: new insights into binding properties

2017 ◽  
Vol 44 (4) ◽  
pp. 353-358 ◽  
Author(s):  
Andrei Santos Siqueira ◽  
Alex Ranieri Jerônimo Lima ◽  
Rafael Conceição de Souza ◽  
Alberdan Silva Santos ◽  
João Lídio da Silva Gonçalves Vianez Júnior ◽  
...  
Keyword(s):  
In Silico ◽  
In Silico Analysis ◽  
Binding Properties ◽  
Silico Analysis
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