In silico analysis of the binding properties of solasonine to mortalin and p53, and in vitro pharmacological studies of its apoptotic and cytotoxic effects on human HepG2 and Hep3b hepatocellular carcinoma cells

2019 ◽  
Vol 33 (4) ◽  
pp. 385-396 ◽  
Author(s):  
Minh Quan Pham ◽  
Thi Hoai Van Tran ◽  
Quoc Long Pham ◽  
Jean Edouard Gairin
Keyword(s):  
Hepatocellular Carcinoma ◽  
In Silico ◽  
In Silico Analysis ◽  
Carcinoma Cells ◽  
Binding Properties ◽  
Cytotoxic Effects ◽  
Hepatocellular Carcinoma Cells ◽  
Pharmacological Studies ◽  
Silico Analysis

scholarly journals In vitro and in vivo cytotoxic effects of PRIMA-1 on hepatocellular carcinoma cells expressing mutant p53ser249

2008 ◽  
Vol 29 (7) ◽  
pp. 1428-1434 ◽  
Author(s):  
H. Shi ◽  
J. M.R. Lambert ◽  
A. Hautefeuille ◽  
V. J.N. Bykov ◽  
K. G. Wiman ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Carcinoma Cells ◽  
Cytotoxic Effects ◽  
Hepatocellular Carcinoma Cells

The role of α2, αv and β1 Integrins in cell growth of hepatocellular carcinoma cells in vitro

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
M Juratli ◽  
A Schnitzbauer ◽  
R Blaheta ◽  
W Bechstein
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Growth ◽  
Carcinoma Cells ◽  
Hepatocellular Carcinoma Cells ◽  
Β1 Integrins

In-Vitro and In-Silico Characterization of Xylose Reductase from Emericella nidulans

2019 ◽  
Vol 13 (2) ◽  
pp. 159-170 ◽  
Author(s):  
Vishal Ahuja ◽  
Aashima Sharma ◽  
Ranju Kumari Rathour ◽  
Vaishali Sharma ◽  
Nidhi Rana ◽  
...  
Keyword(s):  
Production Process ◽  
In Silico ◽  
Xylose Reductase ◽  
In Silico Analysis ◽  
Emericella Nidulans ◽  
Higher Temperature ◽  
In Silico Characterization ◽  
Silico Analysis

Background: Lignocellulosic residues generated by various anthropogenic activities can be a potential raw material for many commercial products such as biofuels, organic acids and nutraceuticals including xylitol. Xylitol is a low-calorie nutritive sweetener for diabetic patients. Microbial production of xylitol can be helpful in overcoming the drawbacks of traditional chemical production process and lowring cost of production. Objective: Designing efficient production process needs the characterization of required enzyme/s. Hence current work was focused on in-vitro and in-silico characterization of xylose reductase from Emericella nidulans. Methods: Xylose reductase from one of the hyper-producer isolates, Emericella nidulans Xlt-11 was used for in-vitro characterization. For in-silico characterization, XR sequence (Accession No: Q5BGA7) was used. Results: Xylose reductase from various microorganisms has been studied but the quest for better enzymes, their stability at higher temperature and pH still continues. Xylose reductase from Emericella nidulans Xlt-11 was found NADH dependent and utilizes xylose as its sole substrate for xylitol production. In comparison to whole cells, enzyme exhibited higher enzyme activity at lower cofactor concentration and could tolerate higher substrate concentration. Thermal deactivation profile showed that whole cell catalysts were more stable than enzyme at higher temperature. In-silico analysis of XR sequence from Emericella nidulans (Accession No: Q5BGA7) suggested that the structure was dominated by random coiling. Enzyme sequences have conserved active site with net negative charge and PI value in acidic pH range. Conclusion: Current investigation supported the enzyme’s specific application i.e. bioconversion of xylose to xylitol due to its higher selectivity. In-silico analysis may provide significant structural and physiological information for modifications and improved stability.

Structure elucidation of arabinogalactoglucan isolated from Sedum sarmentosum Bunge and its inhibition on hepatocellular carcinoma cells in vitro

2021 ◽  
Vol 180 ◽  
pp. 152-160
Author(s):  
Xue Zhang ◽  
Caili Bi ◽  
Qi Chen ◽  
Hairong Xu ◽  
Hongcan Shi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Structure Elucidation ◽  
Carcinoma Cells ◽  
Hepatocellular Carcinoma Cells

scholarly journals RNA methyltransferase NSUN2 promotes growth of hepatocellular carcinoma cells by regulating fizzy‐related‐1 in vitro and in vivo

2021 ◽  
Author(s):  
Chun‐Tao Zhai ◽  
Yi‐Cheng Tian ◽  
Zu‐Xiong Tang ◽  
Long‐Jiang Shao
Keyword(s):  
Hepatocellular Carcinoma ◽  
Carcinoma Cells ◽  
Hepatocellular Carcinoma Cells

Investigation of indole functionalized pyrazoles and oxadiazoles as anti-inflammatory agents: synthesis, in-vivo, in-vitro and in-silico analysis

2021 ◽  
pp. 105068
Author(s):  
Devendra Kumar ◽  
Ravi Ranjan Kumar ◽  
Shelly Pathania ◽  
Pankaj Kumar Singh ◽  
Sourav Kalra ◽  
...  
Keyword(s):  
In Silico ◽  
In Silico Analysis ◽  
Anti Inflammatory ◽  
Silico Analysis

scholarly journals Retraction: MiR-206 reduced the malignancy of hepatocellular carcinoma cells in vitro by inhibiting MET and CTNNB1 gene expressions

RSC Advances ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 4439-4439
Author(s):  
Laura Fisher
Keyword(s):  
Hepatocellular Carcinoma ◽  
Carcinoma Cells ◽  
Gene Expressions ◽  
Hepatocellular Carcinoma Cells ◽  
Ctnnb1 Gene

Retraction of ‘MiR-206 reduced the malignancy of hepatocellular carcinoma cells in vitro by inhibiting MET and CTNNB1 gene expressions’ by Qiang He et al., RSC Adv., 2019, 9, 1717–1725, DOI: 10.1039/C8RA09229J

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