Identification of competitive inhibitors of the human taurine transporter TauT in a human kidney cell line

2019 ◽  
Vol 71 (1) ◽  
pp. 121-129
Author(s):  
Michelle Richter ◽  
Selina J. Moroniak ◽  
Hartmut Michel
Keyword(s):  
Cell Line ◽  
Kidney Cell ◽  
Human Kidney ◽  
Kidney Cell Line ◽  
Taurine Transporter ◽  
Competitive Inhibitors

scholarly journals Analysis of PPAR alpha function in human kidney cell line using siRNA

2006 ◽  
Vol 50 (1) ◽  
pp. 257-258 ◽  
Author(s):  
Keisuke Tachibana ◽  
Naohiko Anzai ◽  
Chihiro Ueda ◽  
Tatsuya Katayama ◽  
Takayoshi Kirino ◽  
...  
Keyword(s):  
Cell Line ◽  
Kidney Cell ◽  
Human Kidney ◽  
Kidney Cell Line ◽  
Ppar Alpha ◽  
Alpha Function

scholarly journals Effect of Known Inhibitors of Ion Transport on Pendrin (SLC26A4) Activity in a Human Kidney Cell Line

2016 ◽  
Vol 38 (5) ◽  
pp. 1984-1998 ◽  
Author(s):  
Emanuele Bernardinelli ◽  
Roberta Costa ◽  
Charity Nofziger ◽  
Markus Paulmichl ◽  
Silvia Dossena
Keyword(s):  
Ion Transport ◽  
Cell Line ◽  
Kidney Cell ◽  
Human Kidney ◽  
Niflumic Acid ◽  
Disulfonic Acid ◽  
Review Of The Literature ◽  
Kidney Cell Line ◽  
Airway Function ◽  
Inflammatory Drugs

Background/Aims: Pendrin is a Cl-/I-/HCO3- exchanger playing a fundamental role in controlling blood pressure and airway function, therefore representing an attractive target for the treatment of hypertensive states and respiratory distresses. A review of the literature regarding the ability of some compounds (namely several known inhibitors of ion transport) to block pendrin activity revealed discordant findings. These incongruous findings may be due, in part, to the concentration of compound and/or the nature of the model system used in the study. Methods: Pendrin activity was evaluated by measuring pendrin-dependent iodide influx following overexpression of the transporter in a human kidney cell line, in the presence of selected test compounds or the respective vehicles. Results: Pendrin activity was significantly hampered by 0.1 mM 5-nitro-2-[(3-phenylpropyl)amino]benzoic acid (NPPB), niflumic acid and tenidap, but was resistant to 0.1 mM 4, 4′-diisothiocyano-2, 2′-stilbene-disulfonic acid (DIDS), furosemide and probenecid. Conclusions: The results of the present study indicate that clinically effective non-steroidal anti-inflammatory drugs (niflumic acid and tenidap) directly inhibit pendrin activity.

Purification and characterization of recombinant human cathepsin E expressed in human kidney cell line 293

2004 ◽  
Vol 37 (1) ◽  
pp. 53-60 ◽  
Author(s):  
Maria G Cappiello ◽  
Zhongren Wu ◽  
Boyd B Scott ◽  
Gerard M McGeehan ◽  
Richard K Harrison
Keyword(s):  
Cell Line ◽  
Kidney Cell ◽  
Human Kidney ◽  
Kidney Cell Line ◽  
Purification And Characterization ◽  
Cathepsin E ◽  
Human Cathepsin
Sign in / Sign up

Export Citation Format

Share Document