Use of curcuminoids in a cohort of patients with oral lichen planus, an autoimmune disease

Oral lichen planus is a relatively common autoimmune disease affecting the middle-aged population. Although no treatment is necessary for a benign asymptomatic case, in case of erosive lichen planus, topical corticosteroids form the mainstay of treatment. In case of failure, apart from tacrolimus, cyclosporine, using the “swish and spit” technique, is a valid therapeutic intervention. In our case, though, this therapeutic option had to be replaced by the systemic use of cyclosporine with gratifying results.

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Possible Mechanisms Involved in the Cooccurrence of Oral Lichen Planus and Hashimoto’s Thyroiditis

Mediators of Inflammation ◽

10.1155/2020/6309238 ◽

2020 ◽

Vol 2020 ◽

pp. 1-9

Author(s):

Peiyao Wu ◽

Shuhan Luo ◽

Tao Zhou ◽

Rui Wang ◽

Xuemei Qiu ◽

...

Keyword(s):

T Cells ◽

Autoimmune Disease ◽

Lichen Planus ◽

Hashimoto’S Thyroiditis ◽

Oral Lichen Planus ◽

Underlying Mechanism ◽

Hashimoto's Thyroiditis ◽

Hormonal Factors ◽

The Past ◽

Oral Lichen

Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disorder mediated by T cells, with a multifactorial etiology. Hashimoto’s thyroiditis (HT) is a common autoimmune disease characterized by hypothyroidism. Although many clinical studies conducted over the past several decades have reported the cooccurrence of OLP and HT, the underlying mechanism remains unclear. This review summarizes potential mechanisms that might be involved in the cooccurrence of OLP and HT. We find that OLP and HT share a common or overlapping pathogenesis in terms of immune, heredity, environmental, and hormonal factors, which might cause cooccurrence. Furthermore, considering the latency of HT, a routine screen for thyroid diseases, particularly HT, is suggested for confirmed OLP patients.

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Mucosal disease

10.1093/med/9780199568741.003.0255 ◽

2018 ◽

Author(s):

Kathy Taghipour

Keyword(s):

Autoimmune Disease ◽

Lichen Planus ◽

Oral Lichen Planus ◽

Pemphigus Vulgaris ◽

Stevens Johnson Syndrome ◽

Mucosal Disease ◽

Johnson Syndrome ◽

Dermatological Condition ◽

A Cell ◽

Oral Lichen

This chapter discusses the following mucous membrane disorders: pemphigus vulgaris, lichen planus, and Stevens–Johnson syndrome. Pemphigus vulgaris is an autoimmune disease that affects the skin and the mucosal membranes with blisters and erosions. Lichen planus is a cell-mediated immunological mucocutaneous disease; oral lichen planus may present with erosions, white streaks, or plaques in the oral cavity. Stevens–Johnson syndrome is an emergency dermatological condition in which an immunological hypersensitivity causes erosions and inflammation of mucosal membranes and the skin. As well as providing definitions of these diseases, this chapter discusses their etiology, typical symptoms, uncommon symptoms, demographics, natural history, complications, diagnostic approach, other diagnoses that should be considered, prognosis, and treatment.

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Oral lichen planus: a novel staging and algorithmic approach and all that is essential to know

F1000Research ◽

10.12688/f1000research.18713.1 ◽

2020 ◽

Vol 9 ◽

pp. 206

Author(s):

Eran Shavit ◽

Klieb Hagen ◽

Neil Shear

Keyword(s):

Quality Of Life ◽

Autoimmune Disease ◽

Lichen Planus ◽

Oral Lichen Planus ◽

Staging System ◽

Oral Lesions ◽

Algorithmic Approach ◽

Chronic Autoimmune Disease ◽

Oral Lichen

Lichen planus (LP) is a chronic autoimmune disease. Oral lesions may occur in isolation or in combination with other affected muco-cutaneous sites. Oral LP (OLP) may present as one of the various manifestations of LP or may present as a disease sui generis with a broad range of severity. Despite this disease targeting the oral mucosa, its great impact on quality of life is underrated. In this article, we provide an updated review of the pathophysiology and epidemiology of OLP and offer guidance for its diagnosis and management. We also propose an algorithmic approach to the clinical forms of OLP and a novel staging system to facilitate management decisions.

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