scholarly journals Possible Mechanisms Involved in the Cooccurrence of Oral Lichen Planus and Hashimoto’s Thyroiditis

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Peiyao Wu ◽  
Shuhan Luo ◽  
Tao Zhou ◽  
Rui Wang ◽  
Xuemei Qiu ◽  
...  
Keyword(s):  
T Cells ◽  
Autoimmune Disease ◽  
Lichen Planus ◽  
Hashimoto’S Thyroiditis ◽  
Oral Lichen Planus ◽  
Underlying Mechanism ◽  
Hashimoto's Thyroiditis ◽  
Hormonal Factors ◽  
The Past ◽  
Oral Lichen

Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disorder mediated by T cells, with a multifactorial etiology. Hashimoto’s thyroiditis (HT) is a common autoimmune disease characterized by hypothyroidism. Although many clinical studies conducted over the past several decades have reported the cooccurrence of OLP and HT, the underlying mechanism remains unclear. This review summarizes potential mechanisms that might be involved in the cooccurrence of OLP and HT. We find that OLP and HT share a common or overlapping pathogenesis in terms of immune, heredity, environmental, and hormonal factors, which might cause cooccurrence. Furthermore, considering the latency of HT, a routine screen for thyroid diseases, particularly HT, is suggested for confirmed OLP patients.

scholarly journals Possible link between Hashimoto's thyroiditis and oral lichen planus: a novel association found

2012 ◽  
Vol 17 (1) ◽  
pp. 333-336 ◽  
Author(s):  
Lorenzo Lo Muzio ◽  
Andrea Santarelli ◽  
Giuseppina Campisi ◽  
MariaGrazia Lacaita ◽  
Gianfranco Favia
Keyword(s):  
Lichen Planus ◽  
Hashimoto’S Thyroiditis ◽  
Oral Lichen Planus ◽  
Hashimoto's Thyroiditis ◽  
Novel Association ◽  
Oral Lichen

Regulatory T-cells and IL17A+ cells infiltrate oral lichen planus lesions

Pathology ◽  
2016 ◽  
Vol 48 (6) ◽  
pp. 564-573 ◽  
Author(s):  
L.R. Javvadi ◽  
V.P.B. Parachuru ◽  
T.J. Milne ◽  
G.J. Seymour ◽  
A.M. Rich
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Lichen

scholarly journals Altered Autophagy-Associated Genes Expression in T Cells of Oral Lichen Planus Correlated with Clinical Features

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Ya-Qin Tan ◽  
Jing Zhang ◽  
Ge-Fei Du ◽  
Rui Lu ◽  
Guan-Ying Chen ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Lichen Planus ◽  
Clinical Features ◽  
Peripheral Blood ◽  
Oral Lichen Planus ◽  
T Cell Response ◽  
Mrna Levels ◽  
Inflammatory Autoimmune Disease ◽  
Oral Lichen

Oral lichen planus (OLP) is a T cell-mediated inflammatory autoimmune disease. Autophagy has emerged as a fundamental trafficking event in mediating T cell response, which plays crucial roles in innate and adaptive immunity. The present study mainly investigated the mRNA expression of autophagy-associated genes in peripheral blood T cells of OLP patients and evaluated correlations between their expression and the clinical features of OLP. Five differentially expressed autophagy-associated genes were identified by autophagy array. Quantitative real-time RT-PCR results confirmed thatIGF1expression in the peripheral blood T cells of OLP patients was significantly higher than that in controls, especially in female and middle-aged (30–50 years old) OLP patients. In addition,ATG9BmRNA levels were significantly lower in nonerosive OLP patients. However, no significant differences were found in the expression ofHGS,ESR1, andSNCAbetween OLP patients and controls. Taken together, dysregulation of T cell autophagy may be involved in immune response of OLP and may be correlated with clinical patterns.

scholarly journals Looking Beyond the Cyclosporine “Swish and Spit” Technique in a Recalcitrant Case of Erosive Lichen Planus Involving the Tongue

2017 ◽  
Vol 9 (3) ◽  
pp. 177-183 ◽  
Author(s):  
Aastha Gupta ◽  
Kabir Sardana ◽  
Ram Kishan Gautam
Keyword(s):  
Autoimmune Disease ◽  
Lichen Planus ◽  
Therapeutic Intervention ◽  
Oral Lichen Planus ◽  
Therapeutic Option ◽  
Aged Population ◽  
Topical Corticosteroids ◽  
Erosive Lichen Planus ◽  
Asymptomatic Case ◽  
Oral Lichen

Oral lichen planus is a relatively common autoimmune disease affecting the middle-aged population. Although no treatment is necessary for a benign asymptomatic case, in case of erosive lichen planus, topical corticosteroids form the mainstay of treatment. In case of failure, apart from tacrolimus, cyclosporine, using the “swish and spit” technique, is a valid therapeutic intervention. In our case, though, this therapeutic option had to be replaced by the systemic use of cyclosporine with gratifying results.

Intra-epithelial CD8+ T cells and basement membrane disruption in oral lichen planus

2002 ◽  
Vol 31 (1) ◽  
pp. 23-27 ◽  
Author(s):  
Xijing J. Zhou ◽  
Philip B. Sugerman ◽  
Neil W. Savage ◽  
Laurence J. Walsh ◽  
Gregory J. Seymour
Keyword(s):  
T Cells ◽  
Basement Membrane ◽  
Lichen Planus ◽  
Cd8 T Cells ◽  
Oral Lichen Planus ◽  
Membrane Disruption ◽  
Oral Lichen
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