Genistein induced anticancer effects on pancreatic cancer cell lines involves mitochondrial apoptosis, G 0 /G 1 cell cycle arrest and regulation of STAT3 signalling pathway

Phytomedicine ◽  
2018 ◽  
Vol 39 ◽  
pp. 10-16 ◽  
Author(s):  
Yi-liang Bi ◽  
Min Min ◽  
Wei Shen ◽  
Yan Liu
Keyword(s):  
Cell Cycle ◽  
Pancreatic Cancer ◽  
Cell Cycle Arrest ◽  
Cell Lines ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Mitochondrial Apoptosis ◽  
Cycle Arrest ◽  
Anticancer Effects ◽  
Stat3 Signalling

Biglycan induced growth inhibition in pancreatic cancer cell lines is caused by cell cycle arrest in G1

2000 ◽  
Vol 118 (4) ◽  
pp. A541
Author(s):  
Gerrit Sommer ◽  
Martina Weimer ◽  
Uli Lacher ◽  
Claudia Ruhland ◽  
Christoph Wenger ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Pancreatic Cancer ◽  
Growth Inhibition ◽  
Cell Cycle Arrest ◽  
Cell Lines ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Lines ◽  
Cycle Arrest

scholarly journals Degalactotigonin, a Steroidal Glycoside from Solanum nigrum, Induces Apoptosis and Cell Cycle Arrest via Inhibiting the EGFR Signaling Pathways in Pancreatic Cancer Cells

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Hoang Le Tuan Anh ◽  
Phuong Thao Tran ◽  
Do Thi Thao ◽  
Duong Thu Trang ◽  
Nguyen Hai Dang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Pancreatic Cancer ◽  
Cell Cycle Arrest ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Solanum Nigrum ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Cycle Arrest

Degalactotigonin (1) and three other steroidal compounds solasodine (2), O-acetyl solasodine (3), and soladulcoside A (4) were isolated from the methanolic extract of Solanum nigrum, and their chemical structures were elucidated by spectroscopic analyses. The isolated compounds were evaluated for cytotoxic activity against human pancreatic cancer cell lines (PANC1 and MIA-PaCa2) and lung cancer cell lines (A549, NCI-H1975, and NCI-H1299). Only degalactotigonin (1) showed potent cytotoxicity against these cancer cell lines. Compound 1 induced apoptosis in PANC1 and A549 cells. Further study on its mechanism of action in PANC1 cells demonstrated that 1 significantly inhibited EGF-induced proliferation and migration in a concentration-dependent manner. Treatment of PANC1 cells with degalactotigonin induced cell cycle arrest at G0/G1 phase. Compound 1 induced downregulation of cyclin D1 and upregulation of p21 in a time- and concentration-dependent manner and inhibited EGF-induced phosphorylation of EGFR, as well as activation of EGFR downstream signaling molecules such as Akt and ERK.

A novel peptide sansalvamide analogue inhibits pancreatic cancer cell growth through G0/G1 cell-cycle arrest

2006 ◽  
Vol 340 (4) ◽  
pp. 1224-1228 ◽  
Author(s):  
Michael B. Ujiki ◽  
Ben Milam ◽  
Xian-Zhong Ding ◽  
Alexandra B. Roginsky ◽  
M. Reza Salabat ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Pancreatic Cancer ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Growth ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest

PANCREATIC CANCER CELL CYCLE ARREST AND APOPTOSIS ARE INDUCED BY A NOVEL DEPSIPEPTIDE SANSALVAMIDE ANALOGUE

Pancreas ◽  
2005 ◽  
Vol 31 (4) ◽  
pp. 475
Author(s):  
M B Ujiki ◽  
X -Z Ding ◽  
A B Roginsky ◽  
M R Salabat ◽  
W Gu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Pancreatic Cancer ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Cycle Arrest

SK-7041, a new histone deacetylase inhibitor, induces G2-M cell cycle arrest and apoptosis in pancreatic cancer cell lines

2006 ◽  
Vol 237 (1) ◽  
pp. 143-154 ◽  
Author(s):  
Ji Kon Ryu ◽  
Woo Jin Lee ◽  
Kwang Hyuck Lee ◽  
Jin-Hyeok Hwang ◽  
Yong-Tae Kim ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Pancreatic Cancer ◽  
Cell Cycle Arrest ◽  
Histone Deacetylase ◽  
Cell Lines ◽  
Histone Deacetylase Inhibitor ◽  
Pancreatic Cancer Cell ◽  
M Cell ◽  
Cycle Arrest ◽  
Deacetylase Inhibitor
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