scholarly journals Altered salt taste response and increased tongue epithelium Scnna1 expression in adult Engrailed-2 null mice

2018 ◽  
Vol 194 ◽  
pp. 410-419 ◽  
Author(s):  
Ankita Gupta ◽  
Xinyi Li ◽  
Emanuel DiCicco-Bloom ◽  
Nicholas T. Bello
Keyword(s):  
Salt Taste ◽  
Taste Response ◽  
Tongue Epithelium

Enhancement of gustatory nerve fibers to NaCl and formation of ion channels by commercial novobiocin

1994 ◽  
Vol 266 (5) ◽  
pp. C1165-C1172 ◽  
Author(s):  
A. M. Feigin ◽  
Y. Ninomiya ◽  
S. M. Bezrukov ◽  
B. P. Bryant ◽  
P. A. Moore ◽  
...  
Keyword(s):  
Ion Channels ◽  
Lipid Bilayers ◽  
Neutral Lipids ◽  
Nerve Fibers ◽  
Chorda Tympani ◽  
Chorda Tympani Nerve ◽  
Salt Taste ◽  
Cation Selectivity ◽  
Taste Response ◽  
Gustatory Nerve

Single fibers of the rat chorda tympani nerve were used to study the mechanism of action of the antibiotic novobiocin on salt taste transduction. In the rat, novobiocin selectively enhanced the responses of sodium-specific and amiloride-sensitive chorda tympani nerve fibers (N type) without affecting more broadly responsive cation-sensitive and amiloride-insensitive fibers (E type). In the presence of amiloride, novobiocin was ineffective at enhancing the response of N-type fibers toward sodium chloride. Novobiocin also increased the conductance of bilayers formed from neutral lipids by forming nonrectifying ion channels with low conductance (approximately 7 pS in 110 mM NaCl), long open times (several seconds and longer), and high cation selectivity. Amiloride did not alter either the conductance or kinetics of these novobiocin channels. These observations suggest that even though novobiocin is able to form cation channels in lipid bilayers, and possibly in cell membranes as well, its action on the salt-taste response is through modulation of existing amiloride-sensitive sodium channels.

Adaptation effect of sucrose on the salt taste response

1992 ◽  
Vol 102 (2) ◽  
pp. 249-252 ◽  
Author(s):  
Keiichi Tonosaki ◽  
Hajimu Uebayashi
Keyword(s):  
Adaptation Effect ◽  
Salt Taste ◽  
Taste Response

Taste Receptors in the Gastrointestinal Tract III. Salty and sour taste: sensing of sodium and protons by the tongue

2006 ◽  
Vol 291 (6) ◽  
pp. G1005-G1010 ◽  
Author(s):  
John A. DeSimone ◽  
Vijay Lyall
Keyword(s):  
Food Selection ◽  
Taste Receptor ◽  
Taste Receptors ◽  
Sour Taste ◽  
Salt Taste ◽  
Taste Response ◽  
Sodium Hydrogen ◽  
Vanilloid Receptor 1 ◽  
Sodium Hydrogen Exchanger ◽  
Tonic Phase

Taste plays an essential role in food selection and consequently overall nutrition. Because salt taste is appetitive, humans ingest more salt than they need. Acids are the source of intrinsically aversive sour taste, but in mixtures with sweeteners they are consumed in large quantities. Recent results have provided fresh insights into transduction and sensory adaptation for the salty and sour taste modalities. The sodium-specific salt taste receptor is the epithelial sodium channel whereas a nonspecific salt taste receptor is a taste variant of the vanilloid receptor-1 nonselective cation channel, TRPV1. The proximate stimulus for sour taste is a decrease in the intracellular pH of a subset of acid-sensing taste cells, which serves as the input to separate transduction pathways for the phasic and tonic parts of the sour neural response. Adaptation to sour arises from the activation of the basolateral sodium-hydrogen exchanger isoform-1 by an increase in intracellular calcium that sustains the tonic phase of the sour taste response.

Basolateral amiloride-sensitive Na+ transport pathway in rat tongue epithelium

1996 ◽  
Vol 76 (2) ◽  
pp. 1297-1309 ◽  
Author(s):  
S. Mierson ◽  
M. M. Olson ◽  
A. E. Tietz
Keyword(s):  
Short Circuit ◽  
Basolateral Membrane ◽  
Na Channels ◽  
Transport Pathway ◽  
Lingual Epithelium ◽  
Taste Response ◽  
Taste Cells ◽  
Rat Tongue ◽  
Tongue Epithelium

1. Experiments were conducted to test for the presence of basolateral Na+ channels in the rat lingual epithelium. Researchers have proposed a model in which some lingual taste cells have Na+ channels in the basolateral membrane. That model is designed to account for the portion of the neural taste response and the portion of the transepithelial short-circuit current (Isc) in vitro that are insensitive to mucosal amiloride; some Na+ would diffuse across the tight junction into the cell via this lateral pathway, and would be transported out of the cell by Na+ pumps in the basal membrane. The model could also account for the differential effect of mucosal amiloride on Na+ salts of various anions, in which the neural taste responses to Na+ salts with anions larger than Cl- are more sensitive to mucosal amiloride than is the taste response to NaCl. 2. Voltage-clamp data were obtained from an in vitro preparation of the anterior-dorsal rat tongue epithelium in which the connective tissue was removed by enzyme digestion. Isc in a modified Ussing chamber was reduced by amiloride in the submucosal solution. 3. The pattern of sensitivity to submucosal amiloride differed in several respects from the pattern for mucosal amiloride. The inhibition constant (Ki) was 52 microM amiloride concentration, higher than for the apical amiloride-sensitive Na+ channel. The selectivity for Na+ over K+ was much less than for the response to mucosal amiloride; with 0.5 M NaCl or KCl on the mucosal side, the ratio of inhibition for the NaCl response to inhibition for the KCl response varied between 1 and 3. 4. As the concentration of NaCl in the mucosal solution was varied, submucosal amiloride caused little inhibition of Isc for mucosal NaCl below isosmotic concentration, with the percent inhibition increasing as mucosal salt concentration increased. With 0.5 M sodium gluconate in the mucosal solution, there was very little inhibition due to submucosal amiloride. 5. The results support the presence of amiloride-sensitive Na+ channels in the basolateral membranes of the dorsal tongue epithelium in rat, and are consistent with the proposed model in which these channels are present in taste cells.

Sex differences in salt taste: The effect of testosterone

1973 ◽  
Vol 10 (4) ◽  
pp. 683-688 ◽  
Author(s):  
J. Křeček
Keyword(s):  
Sex Differences ◽  
Salt Taste

scholarly journals Marginal Zinc Deficiency and Changes in Behavioral Salt Taste Threshold and Salt Preference in Mice.

1991 ◽  
Vol 37 (2) ◽  
pp. 185-199 ◽  
Author(s):  
Xing-Wang LIU ◽  
Yasushi DEJIMA ◽  
Tsuguyoshi SUZUKI ◽  
Sei-ichiro HIMENO ◽  
Yoichi OKAZAKI
Keyword(s):  
Zinc Deficiency ◽  
Taste Threshold ◽  
Salt Taste ◽  
Marginal Zinc Deficiency

EFFICIENCY OF A CYCLIC DESIGN AND A MULTIDIMENSIONAL SCALING SENSORY ANALYSIS TECHNIQUE IN THE STUDY OF SALT TASTE

1995 ◽  
Vol 10 (1) ◽  
pp. 25-44 ◽  
Author(s):  
TERRI ROBERTSON ROSETT ◽  
BARBARA P. KLEIN
Keyword(s):  
Multidimensional Scaling ◽  
Sensory Analysis ◽  
Salt Taste ◽  
Analysis Technique ◽  
Cyclic Design

scholarly journals Regulation of the Putative TRPV1t Salt Taste Receptor by Phosphatidylinositol 4, 5-Bisphosphate

2010 ◽  
Vol 103 (3) ◽  
pp. 1337-1349 ◽  
Author(s):  
Vijay Lyall ◽  
Tam-Hao T. Phan ◽  
ZuoJun Ren ◽  
Shobha Mummalaneni ◽  
Pamela Melone ◽  
...  
Keyword(s):  
Monosodium Glutamate ◽  
Taste Receptor ◽  
Receptor Protein ◽  
Chorda Tympani ◽  
Sprague Dawley ◽  
Salt Taste ◽  
Sprague Dawley Rats ◽  
Enhanced Ct ◽  
Biphasic Effect ◽  
Phosphatidylinositol 4

Regulation of the putative amiloride and benzamil (Bz)-insensitive TRPV1t salt taste receptor by phosphatidylinositol 4,5-bisphosphate (PIP2) was studied by monitoring chorda tympani (CT) taste nerve responses to 0.1 M NaCl solutions containing Bz (5 × 10−6 M; a specific ENaC blocker) and resiniferatoxin (RTX; 0–10 × 10−6 M; a specific TRPV1 agonist) in Sprague-Dawley rats and in wildtype (WT) and TRPV1 knockout (KO) mice. In rats and WT mice, RTX elicited a biphasic effect on the NaCl + Bz CT response, increasing the CT response between 0.25 × 10−6 and 1 × 10−6 M. At concentrations >1 × 10−6 M, RTX inhibited the CT response. An increase in PIP2 by topical lingual application of U73122 (a phospholipase C blocker) or diC8-PIP2 (a short chain synthetic PIP2) inhibited the control NaCl + Bz CT response and decreased its sensitivity to RTX. A decrease in PIP2 by topical lingual application of phenylarsine oxide (a phosphoinositide 4 kinase blocker) enhanced the control NaCl + Bz CT response, increased its sensitivity to RTX stimulation, and inhibited the desensitization of the CT response at RTX concentrations >1 × 10−6 M. The ENaC-dependent NaCl CT responses were not altered by changes in PIP2. An increase in PIP2 enhanced CT responses to sweet (0.3 M sucrose) and bitter (0.01 M quinine) stimuli. RTX produced the same increase in the Bz-insensitive Na+response when present in salt solutions containing 0.1 M NaCl + Bz, 0.1 M monosodium glutamate + Bz, 0.1 M NaCl + Bz + 0.005 M SC45647, or 0.1 M NaCl + Bz + 0.01 M quinine. No effect of RTX was observed on CT responses in WT mice and rats in the presence of the TRPV1 blocker N-(3-methoxyphenyl)-4-chlorocinnamide (1 × 10−6 M) or in TRPV1 KO mice. We conclude that PIP2 is a common intracellular effector for sweet, bitter, umami, and TRPV1t-dependent salt taste, although in the last case, PIP2 seems to directly regulate the taste receptor protein itself, i.e., the TRPV1 ion channel or its taste receptor variant, TRPV1t.

Impact of salt reduction interventions on salt taste sensitivity and liking, a cluster randomized controlled trial

2021 ◽  
Vol 87 ◽  
pp. 104059
Author(s):  
N.L. Riis ◽  
K.S. Bjoernsbo ◽  
U. Toft ◽  
E. Trolle ◽  
G. Hyldig ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Cluster Randomized Controlled Trial ◽  
Taste Sensitivity ◽  
Salt Reduction ◽  
Salt Taste ◽  
Randomized Controlled ◽  
Cluster Randomized
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