scholarly journals Role of membrane integrity on G protein-coupled receptors: Rhodopsin stability and function

2011 ◽  
Vol 50 (3) ◽  
pp. 267-277 ◽  
Author(s):  
Beata Jastrzebska ◽  
Aleksander Debinski ◽  
Slawomir Filipek ◽  
Krzysztof Palczewski
Keyword(s):  
G Protein ◽  
Membrane Integrity ◽  
G Protein Coupled Receptors ◽  
And Function ◽  
G Protein Coupled

scholarly journals The Role of Receptor Oligomerization in Modulating the Expression and Function of Leukocyte Adhesion-G Protein-coupled Receptors

2007 ◽  
Vol 282 (37) ◽  
pp. 27343-27353 ◽  
Author(s):  
John Q. Davies ◽  
Gin-Wen Chang ◽  
Simon Yona ◽  
Siamon Gordon ◽  
Martin Stacey ◽  
...  
Keyword(s):  
G Protein ◽  
Leukocyte Adhesion ◽  
G Protein Coupled Receptors ◽  
Receptor Oligomerization ◽  
And Function ◽  
G Protein Coupled

The Role of Internal Water Molecules in the Structure and Function of the Rhodopsin Family of G Protein-Coupled Receptors

ChemInform ◽  
2007 ◽  
Vol 38 (14) ◽  
Author(s):  
Leonardo Pardo ◽  
Xavier Deupi ◽  
Nicole Doelker ◽  
Maria Luz Lopez-Rodriguez ◽  
Mercedes Campillo
Keyword(s):  
G Protein ◽  
Structure And Function ◽  
G Protein Coupled Receptors ◽  
Water Molecules ◽  
Internal Water ◽  
And Function ◽  
G Protein Coupled

The Role of Internal Water Molecules in the Structure and Function of the Rhodopsin Family of G Protein-Coupled Receptors

ChemBioChem ◽  
2007 ◽  
Vol 8 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Leonardo Pardo ◽  
Xavier Deupi ◽  
Nicole Dölker ◽  
María Luz López-Rodríguez ◽  
Mercedes Campillo
Keyword(s):  
G Protein ◽  
Structure And Function ◽  
G Protein Coupled Receptors ◽  
Water Molecules ◽  
Internal Water ◽  
And Function ◽  
G Protein Coupled

scholarly journals The Role of G Protein-Coupled Receptors in the Right Ventricle in Pulmonary Hypertension

2018 ◽  
Vol 5 ◽  
Author(s):  
Gayathri Viswanathan ◽  
Argen Mamazhakypov ◽  
Ralph T. Schermuly ◽  
Sudarshan Rajagopal
Keyword(s):  
Pulmonary Hypertension ◽  
Right Ventricle ◽  
G Protein ◽  
G Protein Coupled Receptors ◽  
The Right ◽  
G Protein Coupled

scholarly journals The role of membrane curvature elastic stress for function of rhodopsin-like G protein-coupled receptors

Biochimie ◽  
2014 ◽  
Vol 107 ◽  
pp. 28-32 ◽  
Author(s):  
Olivier Soubias ◽  
Walter E. Teague ◽  
Kirk G. Hines ◽  
Klaus Gawrisch
Keyword(s):  
G Protein ◽  
Elastic Stress ◽  
Membrane Curvature ◽  
G Protein Coupled Receptors ◽  
G Protein Coupled

scholarly journals Atypical Chemokine Receptors in Cardiovascular Disease

2019 ◽  
Vol 119 (04) ◽  
pp. 534-541 ◽  
Author(s):  
Selin Gencer ◽  
Emiel van der Vorst ◽  
Maria Aslani ◽  
Christian Weber ◽  
Yvonne Döring ◽  
...  
Keyword(s):  
G Protein ◽  
Chemokine Receptors ◽  
Cellular Response ◽  
Current Knowledge ◽  
G Protein Coupled Receptors ◽  
Signalling Pathways ◽  
Atherosclerosis Development ◽  
G Protein Coupled ◽  
Precise Role

AbstractInflammation has been well recognized as one of the main drivers of atherosclerosis development and therefore cardiovascular diseases (CVDs). It has been shown that several chemokines, small 8 to 12 kDa cytokines with chemotactic properties, play a crucial role in the pathophysiology of atherosclerosis. Chemokines classically mediate their effects by binding to G-protein-coupled receptors called chemokine receptors. In addition, chemokines can also bind to atypical chemokine receptors (ACKRs). ACKRs fail to induce G-protein-dependent signalling pathways and thus subsequent cellular response, but instead are able to internalize, scavenge or transport chemokines. In this review, we will give an overview of the current knowledge about the involvement of ACKR1–4 in CVDs and especially in atherosclerosis development. In the recent years, several studies have highlighted the importance of ACKRs in CVDs, although there are still several controversies and unexplored aspects that have to be further elucidated. A better understanding of the precise role of these atypical receptors may pave the way towards novel and improved therapeutic strategies.

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