Multifunctional antimicrobial materials: from rational design to biomedical applications

2021 ◽  
pp. 100887
Author(s):  
Shun Duan ◽  
Ruonan Wu ◽  
Yan-Hua Xiong ◽  
Hui-Min Ren ◽  
Chengyue Lei ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Rational Design ◽  
Antimicrobial Materials

scholarly journals Molecular dissection of pheromone selectivity in the competence signaling system ComRS of streptococci

2020 ◽  
Vol 117 (14) ◽  
pp. 7745-7754
Author(s):  
Laura Ledesma-Garcia ◽  
Jordhan Thuillier ◽  
Armando Guzman-Espinola ◽  
Imke Ensinck ◽  
Inès Li de la Sierra-Gallay ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Rational Design ◽  
Mutational Analysis ◽  
Point Mutations ◽  
Streptococcus Thermophilus ◽  
Activation Mechanism ◽  
Toggle Switch ◽  
Exogenous Dna ◽  
C Terminus ◽  
Molecular Determinants

Competence allows bacteria to internalize exogenous DNA fragments for the acquisition of new phenotypes such as antibiotic resistance or virulence traits. In most streptococci, competence is regulated by ComRS signaling, a system based on the mature ComS pheromone (XIP), which is internalized to activate the (R)RNPP-type ComR sensor by triggering dimerization and DNA binding. Cross-talk analyses demonstrated major differences of selectivity between ComRS systems and raised questions concerning the mechanism of pheromone-sensor recognition and coevolution. Here, we decipher the molecular determinants of selectivity of the closely related ComRS systems fromStreptococcus thermophilusandStreptococcus vestibularis. Despite high similarity, we show that the divergence in ComR-XIP interaction does not allow reciprocal activation. We perform the structural analysis of the ComRS system fromS. vestibularis.Comparison with its ortholog fromS. thermophilusreveals an activation mechanism based on a toggle switch involving the recruitment of a key loop by the XIP C terminus. Together with a broad mutational analysis, we identify essential residues directly involved in peptide binding. Notably, we generate a ComR mutant that displays a fully reversed selectivity toward the heterologous pheromone with only five point mutations, as well as other ComR variants featuring XIP bispecificity and/or neofunctionalization for hybrid XIP peptides. We also reveal that a single XIP mutation relaxes the strictness of ComR activation, suggesting fast adaptability of molecular communication phenotypes. Overall, this study is paving the way toward the rational design or directed evolution of artificial ComRS systems for a range of biotechnological and biomedical applications.

α-Amino Acid Containing Degradable Polymers as Functional Biomaterials: Rational Design, Synthetic Pathway, and Biomedical Applications

2011 ◽  
Vol 12 (6) ◽  
pp. 1937-1955 ◽  
Author(s):  
Huanli Sun ◽  
Fenghua Meng ◽  
Aylvin A. Dias ◽  
Marc Hendriks ◽  
Jan Feijen ◽  
...  
Keyword(s):  
Amino Acid ◽  
Biomedical Applications ◽  
Rational Design ◽  
Degradable Polymers ◽  
Synthetic Pathway ◽  
Functional Biomaterials

Functional polymer thin films designed for antifouling materials and biosensors

2012 ◽  
Vol 66 (5) ◽  
Author(s):  
Chao Zhao ◽  
Ling-Yan Li ◽  
Ming-Ming Guo ◽  
Jie Zheng
Keyword(s):  
Thin Films ◽  
Biomedical Applications ◽  
Rational Design ◽  
Polymer Thin Films ◽  
Short Review ◽  
Photovoltaic Devices ◽  
Real World Applications ◽  
Energy Conversion And Storage ◽  
And Storage ◽  
Selection Of

AbstractPolymer thin films offer a versatile and ubiquitous platform for a wide variety of real-world applications in biomedicine, nanotechnology, catalysis, photovoltaic devices, and energy conversion and storage. Depending on the chemical composition of the polymers and the associated microenvironment, the physicochemical properties (biocompatibility, stability, wettability, adhesion, morphology, surface free energy, and others) of polymer films can be tuned for a specific application through precisely controlled surface synthesis and the incorporation of desirable and responsive functional groups. In this short review, we first summarise the methods most commonly used for the fabrication of polymer thin films. Then we discuss how these polymer thin films can be used in a selection of biomedical applications in antifouling materials and biosensors. Some directions for the rational design of polymer thin films to achieve a specific function or application are also provided.

scholarly journals Gold Nanomaterials and Bone/Cartilage Tissue Engineering: Biomedical Applications and Molecular Mechanisms

2021 ◽  
Vol 9 ◽  
Author(s):  
Yifeng Shi ◽  
Xuyao Han ◽  
Shuang Pan ◽  
Yuhao Wu ◽  
Yuhan Jiang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Biomedical Applications ◽  
Rational Design ◽  
Molecular Mechanisms ◽  
Materials Science ◽  
Rapid Development ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Gold Nanomaterials ◽  
And Cartilage

Recently, as our population increasingly ages with more pressure on bone and cartilage diseases, bone/cartilage tissue engineering (TE) have emerged as a potential alternative therapeutic technique accompanied by the rapid development of materials science and engineering. The key part to fulfill the goal of reconstructing impaired or damaged tissues lies in the rational design and synthesis of therapeutic agents in TE. Gold nanomaterials, especially gold nanoparticles (AuNPs), have shown the fascinating feasibility to treat a wide variety of diseases due to their excellent characteristics such as easy synthesis, controllable size, specific surface plasmon resonance and superior biocompatibility. Therefore, the comprehensive applications of gold nanomaterials in bone and cartilage TE have attracted enormous attention. This review will focus on the biomedical applications and molecular mechanism of gold nanomaterials in bone and cartilage TE. In addition, the types and cellular uptake process of gold nanomaterials are highlighted. Finally, the current challenges and future directions are indicated.

scholarly journals Rational design of microfabricated electroconductive hydrogels for biomedical applications

2019 ◽  
Vol 92 ◽  
pp. 135-157 ◽  
Author(s):  
Brian W. Walker ◽  
Roberto Portillo Lara ◽  
Emad Mogadam ◽  
Chu Hsiang Yu ◽  
William Kimball ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Rational Design

Multienzyme Nanoassemblies: from Rational Design to Biomedical Applications

2021 ◽  
Author(s):  
Di Li ◽  
Qirong Xiong ◽  
Li Liang ◽  
Hongwei Duan
Keyword(s):  
Biomedical Applications ◽  
Rational Design ◽  
Research Interest

Multienzyme nanoassemblies (MENAs) that combine the functions of several enzymes into one entity have attracted widespread research interest due to their improved enzymatic performance and great potential for diverse applications....

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