Differential involvement of nucleus tractus solitarius projections and locus coeruleus projections to the basolateral amygdala in morphine-associated memory destabilization

2021 ◽  
pp. 110496
Author(s):  
Wei Zheng ◽  
Chao Wu ◽  
Wen-Jie Du ◽  
Yonghui Li ◽  
Fang Shen ◽  
...  
Keyword(s):  
Locus Coeruleus ◽  
Basolateral Amygdala ◽  
Nucleus Tractus Solitarius ◽  
Differential Involvement

scholarly journals Anatomical and functional connections between the locus coeruleus and the nucleus tractus solitarius in neonatal rats

Neuroscience ◽  
2016 ◽  
Vol 324 ◽  
pp. 446-468 ◽  
Author(s):  
L.T. Lopes ◽  
L.G.A. Patrone ◽  
K.-Y. Li ◽  
A.N. Imber ◽  
C.D. Graham ◽  
...  
Keyword(s):  
Locus Coeruleus ◽  
Nucleus Tractus Solitarius ◽  
Neonatal Rats ◽  
Functional Connections

scholarly journals Definition of Brainstem Afferents to Gonadotropin-Releasing Hormone Neurons in the Mouse Using Conditional Viral Tract Tracing

Endocrinology ◽  
2007 ◽  
Vol 148 (12) ◽  
pp. 5884-5890 ◽  
Author(s):  
Rebecca E. Campbell ◽  
Allan E. Herbison
Keyword(s):  
Locus Coeruleus ◽  
Time Course ◽  
Pseudorabies Virus ◽  
Tryptophan Hydroxylase ◽  
Fluorescent Protein ◽  
Nucleus Tractus Solitarius ◽  
Area Postrema ◽  
Brain Regions ◽  
Afferent Input ◽  
Gnrh Neurons

Brainstem monoamines have long been considered to play a role in regulating the activity of GnRH neurons, although their neuroanatomical relationship with these cells has remained unclear. Using a Cre-dependent pseudorabies virus (Ba2001) technique that permits retrograde tracing selectively from GnRH neurons in the mouse, we have examined the organization of brainstem inputs to rostral preoptic area (rPOA) GnRH neurons. Two days after injection of Ba2001 into the rPOA of adult female GnRH-Cre transgenic mice, five to nine GnRH neurons located immediately adjacent to the injection site were found to express green fluorescent protein (GFP), the marker of virus infection, with no GFP expression anywhere else in the brain. In mice killed 24 h later (3 d after injection), GFP-expressing cells were identified (in order of density) in the raphe nuclei, periaqueductal grey, locus coeruleus, nucleus tractus solitarius, and area postrema. This time course is compatible with these neurons representing primary afferent inputs to the GnRH neurons. Four and 6 d after Ba2001 injection, GFP-expressing cells were found in additional brain regions. Dual-label immunofluorescence experiments in 3-d postinjection mice demonstrated that 100% of GFP-expressing neurons in the raphe were positive for tryptophan hydroxylase, whereas 100% and approximately 50% of GFP neurons in the locus coeruleus and nucleus tractus solitarius, respectively, expressed tyrosine hydroxylase. These observations demonstrate that rPOA GnRH neurons receive direct projections from brainstem A2 and A6 noradrenergic neurons and that, surprisingly, the largest afferent input from the brainstem originates from raphe serotonin neurons in the mouse.

scholarly journals Author response: Locus coeruleus to basolateral amygdala noradrenergic projections promote anxiety-like behavior

2017 ◽  
Author(s):  
Jordan G McCall ◽  
Edward R Siuda ◽  
Dionnet L Bhatti ◽  
Lamley A Lawson ◽  
Zoe A McElligott ◽  
...  
Keyword(s):  
Locus Coeruleus ◽  
Basolateral Amygdala ◽  
Author Response

scholarly journals Differential Involvement of the Locus Coeruleus in Early- and Late-Onset Alzheimer’s Disease: A Potential Mechanism of Clinical Differences?

2020 ◽  
Author(s):  
Corey J. Bolton ◽  
Joyce W. Tam
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Locus Coeruleus ◽  
Late Onset ◽  
Clinical Manifestations ◽  
Potential Mechanism ◽  
Attentional Functioning ◽  
Early Onset Alzheimer’S Disease ◽  
Differential Involvement

AbstractEarly-onset Alzheimer’s disease (EOAD) has been associated with an increased likelihood of atypical clinical manifestations such as attentional impairment, yet the cause of this heterogeneity remains unclear. The locus coeruleus (LC) is implicated early in Alzheimer’s disease pathology and is associated with attentional functioning. This study investigated post-mortem atrophy of the LC in EOAD and late-onset Alzheimer’s disease (LOAD) in a large, well-characterized sample. Results show nearly four times greater likelihood of higher LC atrophy in EOAD as compared to LOAD after controlling for other measures of pathological progression (p < .005). Follow-up analyses within the EOAD group revealed that compared to those who displayed mild or no LC atrophy at autopsy, those with moderate-severe atrophy of the LC displayed significantly worse performance on various baseline measures of attentional functioning (p < .05), despite similar overall cognition (p = .25). These findings suggest the LC is an important potential driver of clinical and pathological heterogeneity in EOAD.

scholarly journals Altered norepinephrine turnover in the brain of rats with chronic renal failure.

1994 ◽  
Vol 4 (11) ◽  
pp. 1901-1907
Author(s):  
R Bigazzi ◽  
E Kogosov ◽  
V M Campese
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Locus Coeruleus ◽  
Turnover Rate ◽  
Nucleus Tractus Solitarius ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Norepinephrine Turnover ◽  
Hypothalamic Nuclei ◽  
And Control

Disturbances of the sympathetic nervous system have been described in chronic renal failure, but their role in the genesis and maintenance of hypertension frequently associated with this condition has not been established. The neuroadrenergic activity in brain nuclei involved in the regulation of blood pressure in uremic animals has also not been previously evaluated. In these studies, the neuroadrenergic activity was measured in the anterior, lateral, and posterior hypothalamic nuclei, in the locus coeruleus, and in the nucleus tractus solitarius of Sprague Dawley rats 5/6 nephrectomized or sham operated 4 wk before the experiments. Neuroadrenergic activity was determined by calculating norepinephrine (NE) turnover rate (in picograms per milligram per hour), 3, 6 and 12 h after inhibition of NE synthesis with L-methyltyrosine. The endogenous NE concentration was significantly greater in the posterior hypothalamic nuclei (21,501 +/- 1,777 pg/mg wet wt) and in the locus coeruleus (16,152 +/- 1,114 pg/mg wet tissue) of uremic compared with control rats (12,213 +/- 1,404 and 7,991 +/- 622 pg/mg wet wt, respectively). On the other hand, the endogenous NE content of the nucleus tractus solitarius and the anterior hypothalamic nuclei did not differ between uremic and control rats. The turnover rate of NE in the posterior hypothalamic nuclei of uremic rats (2150 +/- 430 pg/mg per hour) was significantly faster (P < 0.05) than in control rats (977 +/- 244 pg/mg per hour). The turnover rate of NE in the locus coeruleus of uremic rats (2,584 +/- 323 pg/mg per hour) was also significantly faster than in control animals (400 +/- 140 pg/mg per hour; P < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

Sign in / Sign up

Export Citation Format

Share Document