Structural signature of binary sphere mixtures under air impact

2019 ◽  
Vol 357 ◽  
pp. 313-321
Author(s):  
D.Z. Gou ◽  
X.Z. An ◽  
H.Y. Zhao ◽  
H. Zhang ◽  
R.Y. Yang ◽  
...  
Keyword(s):  
2021 ◽  
Author(s):  
Paula Camila A.A.P. Matos ◽  
Thiago J.R. Rezende ◽  
Gabriel S. Schmitt ◽  
Luciana Cardoso Bonadia ◽  
Fabiano Reis ◽  
...  

2008 ◽  
Vol 112 (46) ◽  
pp. 11854-11860 ◽  
Author(s):  
Steve Scheiner ◽  
Tapas Kar

2021 ◽  
Author(s):  
Tao Jiang ◽  
Antonio MONARI ◽  
Elise Dumont ◽  
Emmanuelle Bignon

The 8-oxo-7,8-dihydroguanine, referred to as 8-oxoG, is a highly mutagenic DNA lesion that can provoke the appearance of mismatches if it escapes the DNA Damage Response. The specific recognition of its structural signature by the hOGG1 glycosylase is the first step along the Base Excision Repair pathway, that ensures the integrity of the genome by preventing the emergence of mutations. 8-oxoG formation, structural features and repair have been the matter of extensive research and more recently this active field of research expended to the more complicated case of 8-oxoG within clustered lesions. Indeed, the presence of a second lesion within 1 or 2 helix turns can dramatically impact the repair yields of 8-oxoG by glycosylases. In this work, we use mu-range molecular dynamics simulations and machine learning-based post-analysis to explore the molecular mechanisms associated with the recognition of 8-oxoG by hOGG1 when embedded in a multiple lesions site with a mismatch in 5' or 3'. We delineate the stiffening of the DNA-protein interactions upon the presence of the mismatches, and rationalize the much lower repair yields reported with a 5' mismatch by describing the perturbation of 8-oxoG structural features upon addition of an adjacent lesion.


2013 ◽  
Vol 73 (2) ◽  
pp. 144-152 ◽  
Author(s):  
Tomas Hajek ◽  
Jeffrey Cullis ◽  
Tomas Novak ◽  
Miloslav Kopecek ◽  
Ryan Blagdon ◽  
...  

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
George Priya Doss C. ◽  
Rajith B. ◽  
Chiranjib Chakraborty ◽  
NagaSundaram N. ◽  
Shabana Kouser Ali ◽  
...  

2017 ◽  
Vol 463 ◽  
pp. 25-30 ◽  
Author(s):  
Bu Wang ◽  
N M Anoop Krishnan ◽  
Yingtian Yu ◽  
Mengyi Wang ◽  
Yann Le Pape ◽  
...  

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Y. M. Lu ◽  
J. F. Zeng ◽  
S. Wang ◽  
B. A. Sun ◽  
Q. Wang ◽  
...  

2014 ◽  
Vol 111 (39) ◽  
pp. 14052-14056 ◽  
Author(s):  
Jun Ding ◽  
Sylvain Patinet ◽  
Michael L. Falk ◽  
Yongqiang Cheng ◽  
Evan Ma

1987 ◽  
Vol 24 (8) ◽  
pp. 1507-1525 ◽  
Author(s):  
W. M. Schwerdtner

Grenville gneiss of the central Georgian Bay region was subjected to ductile deformation that produced narrow mylonite zones as well as three sets of superimposed folds differing greatly in structural signature, size, and orientation. Some mylonite zones are concordant to gneissosity and are repeatedly folded, others cut gneissosity and postdate the folding. Gneissosity was generated as a regionally subhorizontal feature, either by crustal thinning or, like the early mylonite zones, by low-angle reverse shearing. An attempt is made to account for the initially subhorizontal gneissosity, the mylonite zones, and the folds in a regime of large-scale reverse shearing that strikes parallel to the Grenville Front.Upright northwest–southwest to north–south buckle folds dominate the map pattern and are subperpendicular to the reverse Grenville Front boundary fault. These set-2 folds cannot be attributed to reverse simple shearing but require a large component of east–west compression. Such stress could have been generated in a northwest–southeast zone of sinistral ductile shear caused by temporary locking of the southern segment of the Grenville Front boundary fault (now under Lake Huron).All structural facts can be explained without large differential translations of crustal slices. For example, most discordances in the regional gneissosity pattern could have been created by décollement and repeated buckling. Detailed geobarometry and petrologic studies may be required to settle the question of large-scale thrusting within the Grenville gneiss terrane.


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