P-028. Study of mean platelet volume in first trimester of pregnancy and its association with development of preeclampsia

2021 ◽  
Vol 25 ◽  
pp. e38
Author(s):  
Vandana Solanki ◽  
Urmila Singh ◽  
Seema Mehrotra ◽  
Shailja Kr
Keyword(s):  
Mean Platelet Volume ◽  
First Trimester ◽  
Platelet Volume ◽  
First Trimester Of Pregnancy

Could mean platelet volume in late first trimester of pregnancy predict intrauterine growth restriction and pre-eclampsia?

2014 ◽  
Vol 40 (7) ◽  
pp. 1840-1845 ◽  
Author(s):  
Mine Kanat-Pektas ◽  
Ufuk Yesildager ◽  
Nadire Tuncer ◽  
Dagistan T. Arioz ◽  
Gulengul Nadirgil-Koken ◽  
...  
Keyword(s):  
Mean Platelet Volume ◽  
Intrauterine Growth Restriction ◽  
First Trimester ◽  
Growth Restriction ◽  
Platelet Volume ◽  
Intrauterine Growth ◽  
First Trimester Of Pregnancy

scholarly journals Determining diagnostic markers of intrautering growth retardation in early pregnancy

2021 ◽  
Vol 1 ◽  
pp. 61-65
Author(s):  
Yu.P.  Vdovichenko ◽  
V.O.  Golyanovskyi
Keyword(s):  
Pregnant Women ◽  
Mean Platelet Volume ◽  
Intrauterine Growth Restriction ◽  
First Trimester ◽  
Growth Restriction ◽  
Morbidity And Mortality ◽  
Perinatal Morbidity ◽  
Platelet Volume ◽  
Intrauterine Growth ◽  
First Trimester Of Pregnancy

Intrauterine growth restriction is the cause of significant increases in perinatal mortality, morbidity and problems in the development of newborns and infants. The leading place of this pathology is not accidental, because according to various authors, the frequency of perinatal loss associated with it is from 19 to 287‰ and more, the level of perinatal morbidity - from 58.7 to 88.0%.The objective: To determine certain serum and ultrasound markers during the first trimester of pregnancy and to improve the perinatal morbidity and mortality rate in women with intrauterine growth restriction. Materials and methods. A prospective study of pregnant women in the gestation period of 11 weeks 0 days – 13 weeks 6 days, which was to determine the level of plasma protein A associated with pregnancy (PAPP-A), mean platelet volume (MPV), and ultrasound placenta examination. Pregnant women were divided into 2 groups: the main group (n1-52) and the control group (n2-50). The study group consisted of women with a low PAPP-A level and changes in the mean platelet volume towards their increase. It is this group of women that is more sensitive, in our opinion, for the development of placental disorders and the occurrence of fetal growth retardation.Results. In this study, PAPP-А levels in 39 pregnant women were <0.5 MoM, and WTO levels in 36 cases were> 10 fl, which, according to the literature, can be used as markers of early prediction of ZRP.Ultrasound type of disorders of the first stage of trophoblast invasion is described as intra- and / or periplacental pathological areas, which can be considered the causes of placental insufficiency, which results in a risk of ZRP. According to the study, high specificity and sensitivity of Doppler parameters with the determination of indices (PI and IR) in the uterine arteries were established. Conclusions. The results of the study showed that performing a screening based on a detailed history and determining PAPP-A, MPV, and ultrasound examination at first trimester of pregnancy in women with the risk of IUGR allows for prophylactic treatment and monitoring of pregnancy and thus reduces neonatal morbidity and mortality.

scholarly journals Association of Complete Blood Count Parameters with Gestational Diabetes Mellitus

2017 ◽  
pp. 1 ◽  
Author(s):  
Zehra Vural Yılmaz ◽  
Elif Yılmaz ◽  
Bilal İçer ◽  
Tuncay Küçüközkan
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Blood Count ◽  
Complete Blood Count ◽  
First Trimester ◽  
Red Cell ◽  
Platelet Volume ◽  
Distribution Width ◽  
First Trimester Of Pregnancy

<p><strong>Objective:</strong> The aim of this study is to evaluate the relationship between hematological changes in early pregnancy using complete blood count parameters and gestational diabetes mellitus.<br /><strong>Study Design:</strong> One hundred pregnant with gestational diabetes mellitus and one hundred healthy pregnant were included in the study. Blood samples for routine complete blood count parameters in first trimester of pregnancy were analyzed. <br /><strong>Results:</strong> In the gestational diabetes mellitus group white blood cell, platelet count, neutrophil and lymphocyte count, mean platelet volume, red cell distribution width were significantly higher than control group. However, there was no significant difference between groups with regard to neutrophil to lymphocyte ratio and platelet to lymphocyte ratio levels. In binary logistic regression analysis; first trimester mean platelet volume and red cell distribution width values were found to be independently associated with diagnosis of gestational diabetes mellitus. <br /><strong>Conclusion:</strong> This study demonstrates that hematological parameters in first trimester of pregnancy are closely associated with gestational diabetes mellitus. The parameters that are routinely and automatically calculated in complete blood count; may be used to predict gestational diabetes mellitus.</p>

Role of mean platelet volume in pregnancy to predict gestational diabetes mellitus in the first trimester

2019 ◽  
Vol 33 (21) ◽  
pp. 3689-3694 ◽  
Author(s):  
Eser Colak ◽  
Emel Ebru Ozcimen ◽  
Mehmet Ufuk Ceran ◽  
Yusuf Aytac Tohma ◽  
Sevsen Kulaksızoglu
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Mean Platelet Volume ◽  
First Trimester ◽  
Platelet Volume ◽  
In Pregnancy

scholarly journals Mean platelet volume in the first trimester as a predictor of gestational diabetes mellitus

2020 ◽  
Vol 133 (11) ◽  
pp. 1364-1365 ◽  
Author(s):  
Zhuo Ren ◽  
Li Lin ◽  
Zhi Li ◽  
Xin-Ping Sun ◽  
Kai Yang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Mean Platelet Volume ◽  
First Trimester ◽  
Platelet Volume

Early onset preeclampsia is associated with an elevated mean platelet volume (MPV) and a greater rise in MPV from time of booking compared with pregnant controls: results of the CAPE study

2018 ◽  
Vol 46 (9) ◽  
pp. 1010-1015 ◽  
Author(s):  
Cathy Monteith ◽  
Karl Egan ◽  
Hugh O’Connor ◽  
Patricia Maguire ◽  
Barry Kevane ◽  
...  
Keyword(s):  
Mean Platelet Volume ◽  
Early Onset ◽  
First Trimester ◽  
P Value ◽  
Antenatal Visit ◽  
Platelet Volume ◽  
Tertiary Referral Centre ◽  
Nice Guideline ◽  
Significant Difference ◽  
Early Onset Preeclampsia

Abstract Objective: To characterise Mean platelet volume (MPV) in patients with early onset preeclampsia (EOPE) and unaffected controls from time of first antenatal visit until the postpartum. Materials and methods: Retrospective secondary analysis of an observational study in an Irish tertiary referral centre with 9000 deliveries annually. The MPV of 27 women with EOPE was compared to 19 unaffected controls. The inclusion criteria for the disease state was the development of EOPE defined by the National Institute for Health and Care Excellence (NICE) guideline, as new onset hypertension presenting after 20 weeks and prior to 34 weeks with significant proteinuria. Between October 2013 and July 2015 we recruited 27 women with EOPE and 19 pregnant controls. Statistical analysis was performed using paired T-test of Mann-Whitney test where appropriate and a P-value <0.05 was deemed significant. Results: At time of diagnosis and late in the third trimester MPV was significantly increased to 9.0 (±0.3) fL in cases of EOPE in comparison to 8.5 (±0.6) fL in normotensive controls (P<0.05). There was no significant difference during the first trimester or postpartum when comparing the MPV in EOPE to controls. Conclusion: Despite an increased MPV at time of diagnosis of EOPE this study did not demonstrate a potential use for increased MPV as a first trimester screening tool.

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