Evaluation of the effect of crude extract purity and pure paclitaxel content on the increased surface area fractional precipitation process for the purification of paclitaxel

2012 ◽  
Vol 47 (12) ◽  
pp. 2388-2397 ◽  
Author(s):  
Ji-Yeon Lee ◽  
Jin-Hyun Kim
2020 ◽  
Vol 27 (13) ◽  
pp. 14642-14653
Author(s):  
Fengqin Yu ◽  
Lin Huangfu ◽  
Chao Wang ◽  
Changming Li ◽  
Jian Yu ◽  
...  

Author(s):  
Pavel Kudryavtsev

The results of studies of the process of hydrated alumina homogeneous precipitation were presented in this work. The variants of this process are considered. The most convenient embodiment of this process is the precipitation of hydrated alumina from its salts with the use of auxiliary substances, such as urea. Urea hydrolysis allows a homogeneous precipitation process under the most mild conditions. It is shown that the process of hydrolytic precipitation in the aluminum salt-urea system proceeds according to the dissociative mechanism SN1. This article analyzes the regularities of precipitation of solid colloidal particles of hydrated metal oxides on the surface of various substrates. Two models of this process are proposed. The proposed α-model is a process of continuous nucleation of interaction centers, at random points of a free surface throughout the process. The proposed β-model provides for the instantaneous nucleation of these centers when they are randomly distributed over the entire surface of the substrate. Based on the proposed models, the average values of the following values are calculated: the thickness of the gel film; its roughness and specific surface area. The calculations carried out in the article showed that these parameters are universal functions of the degree of filling of the surface and do not depend on the specific model of the mechanism of the process. Studies have been conducted on the use of homogeneously precipitated aluminum hydroxide as a binder in the preparation of porous materials. The resulting materials have a developed specific surface area and porosity.


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