In three specific model instantiations, this chapter demonstrates how URANOS can be applied to other research domains. The first instantiation, referred to as the body-mind continuum, addresses humans as holistic and spiritual beings embedded in their natural, informational and socio-cultural environments. The second instantiation provides a framework for integral thinking and designing based on the AQAL-model from K. Wilber (2007). The third instantiation addresses holistic and cognitive coordination processes in the context of multi-agent and cyber-physical systems. These three instantiations together build the core of our human-centered modeling approach. Each of them holds our generic system model at its core, but at the same time has its own specific extensions.