Background & Objective: Colorectal cancer is the third most prevalent malignancy with high mortality rate,
necessitating markers that predict survival and guide the treatment. Previous studies have examined the
immunohistochemical expression of Bcl-2, anti apoptotic marker, in colorectal carcinoma, but results have been
contradictory.To evaluate the histopathological features of colorectal carcinoma, immunohistochemical expression of
Bcl-2 must be analyzed to find out statistical association of Bcl-2 expression with certain prognostic factors
histopathologic type, grade and TNM staging and also clinical parameters like age gender, site. Methods: This
prospective study was conducted on the colectomy specimens of colorectal carcinoma,over a period of 2 years 6months
From may 2018 to November 2020 The tumor morphology and Bcl-2 status were evaluated by immunohistochemistry in
each case,with the inclusion criteria of resected intestinal specimens among which only malignant epithelial lesions and
exclusion of all benign lesions. Results:The study included 40 cases,with age group of patients 51-60(37.5%) years and
male:female ratio of 1.2:1.Bcl-2 positivity was seen in 37.5% of the cases.Weak,moderate,and strong expression of Bcl-2
was seen in 62.5%, 25%, and 12.5% of cases respectively. Even though early stages of colorectal carcinoma showed
greater frequency of Bcl-2 expression than advanced stages (25% versus 12.5%), however this association was not
statistically significant. Conclusion: The expression of bcl 2 out of 40 resected specimens of colorectal carcinoma
correlated with various histological and clinical paramaters .bcl 2 positivity was assessed by semiquantitaive method
and its expression was decreased with increase in grade and stage of the tumour and increased with the early stages of
colorectal cancer
CORRELATION OF BCL 2 ONCOPROTEIN EXPRESSION AND ITS PROGNOSTIC SIGNIFICANCE IN COLORECTAL CARCINOMA WITH AGE, SITE GRADE AND STAGE
