PARP-1 inhibitor-AG14361 suppresses acute allograft rejection via stabilizing CD4+FoxP3+ regulatory T cells

2020 ◽  
Vol 216 (8) ◽  
pp. 153021
Author(s):  
Wei Gu ◽  
Ruru Ge ◽  
Fangming Zhu ◽  
Dan Li ◽  
Rui Liang ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Allograft Rejection ◽  
Acute Allograft Rejection ◽  
Parp 1

scholarly journals The Ratio of Circulating Regulatory T Cells (Tregs)/Th17 Cells Is Associated with Acute Allograft Rejection in Liver Transplantation

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e112135 ◽  
Author(s):  
Ying Wang ◽  
Min Zhang ◽  
Zhen-Wen Liu ◽  
Wei-Guo Ren ◽  
Yan-Chao Shi ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
T Cells ◽  
Regulatory T Cells ◽  
Allograft Rejection ◽  
Th17 Cells ◽  
Acute Allograft Rejection

CD25+CD4+ Regulatory T Cells Develop in Mice Not Only During Spontaneous Acceptance of Liver Allografts but Also After Acute Allograft Rejection

2006 ◽  
Vol 82 (9) ◽  
pp. 1202-1209 ◽  
Author(s):  
Ulrich Steger ◽  
Cherry I. Kingsley ◽  
Mahzuz Karim ◽  
Andrew R. Bushell ◽  
Kathryn J. Wood
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Allograft Rejection ◽  
Acute Allograft Rejection

scholarly journals Poly(ADP-ribosyl)ation of FOXP3 protein mediated by PARP-1 regulates the function of regulatory T cells.

2016 ◽  
Vol 291 (3) ◽  
pp. 1201-1201 ◽  
Author(s):  
Xuerui Luo ◽  
Jia Nie ◽  
Shuaiwei Wang ◽  
Zuojia Chen ◽  
WanJun Chen ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Parp 1

Circulating CXCR3-CCR6-CXCR5+CD4+ T cells are associated with acute allograft rejection in liver transplantation

2019 ◽  
Vol 213 ◽  
pp. 55-61 ◽  
Author(s):  
Ke Zhang ◽  
Yan-Ling Sun ◽  
Shuang-Nan Zhou ◽  
Ruo-Nan Xu ◽  
Zhen-Wen Liu ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
T Cells ◽  
Allograft Rejection ◽  
Cd4 T Cells ◽  
Acute Allograft Rejection

scholarly journals Alloreactive regulatory T cells generated with retinoic acid prevent skin allograft rejection

2014 ◽  
Vol 45 (2) ◽  
pp. 452-463 ◽  
Author(s):  
Carolina Moore ◽  
Gabriela Tejon ◽  
Camila Fuentes ◽  
Yessia Hidalgo ◽  
Maria R. Bono ◽  
...  
Keyword(s):  
T Cells ◽  
Retinoic Acid ◽  
Regulatory T Cells ◽  
Allograft Rejection ◽  
Skin Allograft

P761The effect of extracorporeal photopheresis on cardiac allograft rejection and on lymphocyte subclasses

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
T Teszak ◽  
A Assabiny ◽  
A Kiraly ◽  
Z Tarjanyi ◽  
N Parazs ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
B Lymphocytes ◽  
Heart Transplant ◽  
Allograft Rejection ◽  
Cytotoxic T Cells ◽  
Cardiac Allograft ◽  
Extracorporeal Photopheresis ◽  
Cardiac Allograft Rejection ◽  
Cellular Rejection

Abstract Background Cardiac allograft rejection is known to have a profound impact on graft survival and mortality after heart transplant. Previous data on the efficacy of extracorporeal photopheresis (ECP) in the management of cardiac allograft rejection is encouraging. Though, clear evidence on the exact indication and data regarding its effect on distinct lymphocyte subtypes are still lacking. Based on their cytokine production, both helper and cytotoxic T cells can differentiate into either regulatory cells participating in the suppression of rejection or into effector cells responsible for its maintenance. Regulatory T cells are essential for the termination of rejection, while B lymphocytes and natural killer (NK) cells contribute to it. Purpose We aimed to investigate the anti-rejection efficacy and the impact of ECP on peripheral blood lymphocyte subclasses in adult heart transplant recipients. Methods In a retrospective analysis of 12 consecutive patients treated with ECP for cardiac allograft rejection between 2013 and 2019, we examined the grade of rejection in endomyocardial biopsies (EMB) based on the International Society for Heart and Lung Transplantation classification. We analysed the absolute counts and the percentages of helper, cytotoxic and regulatory T cells, B lymphocytes and NK cells with fluorescence activated cell sorting. Measurements were performed both before and after the ECP treatment period. Data values were given as either mean±standard deviation or median [min–max]. Results The patients underwent 26 [2–39] ECP treatments in addition to standard immunosuppressant therapy. Whereas grade 2R cellular rejection was detected in 83% of the cases prior to initiating ECP, none of the examined EMB specimen revealed rejection greater than grade 1R cellular rejection post ECP therapy. The average grade of cellular rejection improved significantly (1.25±0.45 vs. 0.50±0.53; p=0.022). The absolute count and the percentage of helper T cells increased significantly post ECP therapy (0.34 G/l±0.26 G/l vs. 0.51 G/l±0.39 G/l; p=0.018 and 3.43%±2.24% vs. 5.98%±3.64%; p=0.017, respectively). There was also a significant rise in the percentage of cytotoxic T cells (2.33%±1.46% vs. 4.16±2.98%; p=0.027). We noticed an almost significant twofold increase in the percentage of regulatory T cells on completion of the ECP therapy (0.20%±0.22% vs. 0.37%±0.20%; p=0.060). Neither B lymphocyte nor NK cell counts revealed any significant changes. Conclusion ECP was effective in reducing the severity of cardiac allograft rejection episodes. The significant decrease in rejection rates might be indicative of the predominance of anti-inflammatory helper and cytotoxic T cell subpopulations and the increase of regulatory T cell count post ECP therapy. However, discussion of the results are limited by small sample size and the effect of medical therapy on the lymphocytes.

Sign in / Sign up

Export Citation Format

Share Document