Impairment in associative memory in healthy aging is distinct from that in other types of episodic memory

2012 ◽  
Vol 197 (1-2) ◽  
pp. 135-139 ◽  
Author(s):  
Henry Silver ◽  
Craig Goodman ◽  
Warren B. Bilker
Keyword(s):  
Episodic Memory ◽  
Associative Memory ◽  
Healthy Aging

scholarly journals Task-dependent Activity and Connectivity Predict Episodic Memory Network-based Responses to Brain Stimulation in Healthy Aging

2014 ◽  
Vol 7 (2) ◽  
pp. 287-296 ◽  
Author(s):  
Dídac Vidal-Piñeiro ◽  
Pablo Martin-Trias ◽  
Eider M. Arenaza-Urquijo ◽  
Roser Sala-Llonch ◽  
Imma C. Clemente ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Brain Stimulation ◽  
Healthy Aging ◽  
Dependent Activity ◽  
Memory Network

scholarly journals Connectome-based Modeling of Mnemonic Discrimination in Younger and Older Adults

2021 ◽  
Author(s):  
Christopher N Wahlheim ◽  
Alexander P Christensen ◽  
Zachariah M Reagh ◽  
Brittany S Cassidy
Keyword(s):  
Older Adults ◽  
Episodic Memory ◽  
Age Differences ◽  
Healthy Aging ◽  
Resting State Functional Connectivity ◽  
Neural Basis ◽  
Discrimination Ability ◽  
Core Feature ◽  
Predictive Relationship ◽  
Novel Associations

The ability to distinguish existing memories from similar perceptual experiences is a core feature of episodic memory. This ability is often examined using the Mnemonic Similarity Task in which people discriminate memories of studied objects from perceptually similar lures. Studies of the neural basis of such mnemonic discrimination have focused on hippocampal function and connectivity. However, default mode network (DMN) connectivity may also support such discrimination, given that the DMN includes the hippocampus, and its connectivity supports many aspects of episodic memory. Here, we used connectome-based modeling to identify associations between intrinsic DMN connectivity and mnemonic discrimination. We leveraged established discrimination deficits in older adults to test whether such age differences moderate network-wide relationships. Resting-state functional connectivity in the DMN predicted mnemonic discrimination ability outside the MRI scanner, especially among prefrontal and temporal regions and including several hippocampal regions. This predictive relationship was stronger for younger than older adults, with age differences primarily reflecting older adults' weaker temporal-prefrontal connectivity. These novel associations suggest that broader cortical networks including the hippocampus support mnemonic discrimination. They also suggest that disruptions within the DMN that emerge in healthy aging undermine the extent that the DMN supports this ability. These findings provide the first indication of how intrinsic functional properties of the DMN support mnemonic discrimination.

scholarly journals Elevated systolic blood pressure is associated with episodic memory decline in healthy aging

2020 ◽  
Vol 16 (S10) ◽  
Author(s):  
Cristina Solé‐Padullés ◽  
Lídia Vaqué‐Alcázar ◽  
Kilian Abellaneda‐Pérez ◽  
Emilio Ros ◽  
David Bartres‐Faz
Keyword(s):  
Blood Pressure ◽  
Episodic Memory ◽  
Systolic Blood Pressure ◽  
Healthy Aging ◽  
Memory Decline ◽  
Elevated Systolic Blood Pressure

Naturalistic Action Performance Distinguishes Amnestic Mild Cognitive Impairment from Healthy Aging

2015 ◽  
Vol 21 (6) ◽  
pp. 419-428 ◽  
Author(s):  
David A. Gold ◽  
Norman W. Park ◽  
Kelly J. Murphy ◽  
Angela K. Troyer
Keyword(s):  
Differential Diagnosis ◽  
Cognitive Impairment ◽  
Executive Function ◽  
Mild Cognitive Impairment ◽  
Episodic Memory ◽  
Healthy Aging ◽  
Group Membership ◽  
Binary Logistic Regression ◽  
Semantic Knowledge ◽  
Amnestic Mild Cognitive Impairment

AbstractIndividuals with amnestic mild cognitive impairment (aMCI) show minor decrements in their instrumental activities of daily living (IADL). Sensitive measures of IADL performance are needed to capture the mild difficulties observed in aMCI groups. Routine naturalistic actions (NAs) are familiar IADL-type activities that require individuals to enact everyday tasks such as preparing coffee. In the current study we examined the extent to which NAs could be used to help facilitate differential diagnosis of aMCI relative to composite measures of episodic memory, semantic knowledge, and executive function. Healthy older adults (n=24) and individuals with aMCI (n=24) enacted two highly familiar NAs and completed tests of episodic memory, semantic knowledge, and executive function. Binary logistic regression was used to predict group membership (aMCI vs. control participants). The regression analyses indicated that NA performance could reliably predict group membership, over and above measures of cognitive functioning. These findings indicated that NA performance can be used to help facilitate differential diagnosis of healthy aging and aMCI and used as an outcome measure in intervention studies. (JINS, 2015, 21, 419–428)

Dopamine Receptor Genes Modulate Associative Memory in Old Age

2017 ◽  
Vol 29 (2) ◽  
pp. 245-253 ◽  
Author(s):  
Goran Papenberg ◽  
Nina Becker ◽  
Beata Ferencz ◽  
Moshe Naveh-Benjamin ◽  
Erika J. Laukka ◽  
...  
Keyword(s):  
Older Adults ◽  
Episodic Memory ◽  
Associative Memory ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
Memory Task ◽  
Population Based ◽  
Item Memory ◽  
Nucleotide Polymorphisms ◽  
Genetic Score

Previous research shows that associative memory declines more than item memory in aging. Although the underlying mechanisms of this selective impairment remain poorly understood, animal and human data suggest that dopaminergic modulation may be particularly relevant for associative binding. We investigated the influence of dopamine (DA) receptor genes on item and associative memory in a population-based sample of older adults (n = 525, aged 60 years), assessed with a face–scene item associative memory task. The effects of single-nucleotide polymorphisms of DA D1 (DRD1; rs4532), D2 (DRD2/ANKK1/Taq1A; rs1800497), and D3 (DRD3/Ser9Gly; rs6280) receptor genes were examined and combined into a single genetic score. Individuals carrying more beneficial alleles, presumably associated with higher DA receptor efficacy (DRD1 C allele; DRD2 A2 allele; DRD3 T allele), performed better on associative memory than persons with less beneficial genotypes. There were no effects of these genes on item memory or other cognitive measures, such as working memory, executive functioning, fluency, and perceptual speed, indicating a selective association between DA genes and associative memory. By contrast, genetic risk for Alzheimer disease (AD) was associated with worse item and associative memory, indicating adverse effects of APOE ε4 and a genetic risk score for AD (PICALM, BIN1, CLU) on episodic memory in general. Taken together, our results suggest that DA may be particularly important for associative memory, whereas AD-related genetic variations may influence overall episodic memory in older adults without dementia.

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