Evaluation of the Frequency Following Response as a Predictive Biomarker of Response to Cognitive Training in Schizophrenia

Neurophysiological biomarkers of auditory processing show promise predicting outcomes following auditory-based targeted cognitive training (TCT) interventions in patients with schizophrenia, but the viability of the early frequency following response (FFR) as a biomarker has yet to be examined, despite its ecological and face validity for auditory-based interventions. FFR is an event-related potential (ERP) that reflects the earliest stages of auditory processing. We predicted that schizophrenia patients would show acute- and longer-term FFR malleability in the context of auditory-based TCT. Fifty-two schizophrenia patients were randomized to either TCT (n = 30) or treatment as usual (TAU; n = 22), and electroencephalography was recorded during rapid presentation of an auditory speech stimulus before treatment, after one hour of training, and after 30 hours of training. Patients in the TCT group did not show changes in FFR after training, but FFR measurements in the TAU group diminished over time. FFR was positively associated with performance on a measure of single word-in-noise perception in the TCT group, and with performance on a measure of sentence-in-noise perception in both TCT and TAU groups. Psychometric reliability analyses of FFR scores indicated high internal consistency but low test-rest reliability between sessions one hour and 12 weeks apart. While the present study did not find evidence of FFR malleability or utility in predicting response to auditory-based TCT, significant associations were observed between FFR measures and behavioral measures of speech discriminability. These findings support the dissociation between measures of speech discriminability along the hierarchy of cortical and subcortical early auditory information processing in schizophrenia.

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Mismatch Negativity is a Sensitive and Predictive Biomarker of Perceptual Learning During Auditory Cognitive Training in Schizophrenia

Neuropsychopharmacology ◽

10.1038/npp.2017.25 ◽

2017 ◽

Vol 42 (11) ◽

pp. 2206-2213 ◽

Cited By ~ 42

Author(s):

Veronica B Perez ◽

Melissa Tarasenko ◽

Makoto Miyakoshi ◽

Sean T Pianka ◽

Scott D Makeig ◽

...

Keyword(s):

Perceptual Learning ◽

Cognitive Training ◽

Mismatch Negativity ◽

Predictive Biomarker

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SU62. The 40-Hz Auditory Steady-State Response: A Sensitive and Predictive Biomarker of Perceptual Learning During Cognitive Training

Schizophrenia Bulletin ◽

10.1093/schbul/sbx024.060 ◽

2017 ◽

Vol 43 (suppl_1) ◽

pp. S183-S184

Author(s):

Wen Zhang ◽

Alexandra Shiluk ◽

Sonia Rackelmann ◽

Melissa Tarasenko ◽

Michael Thomas ◽

...

Keyword(s):

Steady State ◽

Perceptual Learning ◽

Cognitive Training ◽

Predictive Biomarker ◽

Steady State Response ◽

State Response ◽

Auditory Steady State Response ◽

40 Hz

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Characteristics of the Frequency-Following Response to Speech in Neonates and Potential Applicability in Clinical Practice: A Systematic Review

Journal of Speech Language and Hearing Research ◽

10.1044/2020_jslhr-19-00322 ◽

2020 ◽

Vol 63 (5) ◽

pp. 1618-1635

Author(s):

Céline Richard ◽

Mary Lauren Neel ◽

Arnaud Jeanvoine ◽

Sharon Mc Connell ◽

Alison Gehred ◽

...

Keyword(s):

Systematic Review ◽

Cochrane Library ◽

Neurodevelopmental Outcomes ◽

Frequency Following Response ◽

Ovid Medline ◽

Published Evidence ◽

Mesh Terms ◽

Potential Applicability ◽

Clinical Potential

Purpose We sought to critically analyze and evaluate published evidence regarding feasibility and clinical potential for predicting neurodevelopmental outcomes of the frequency-following responses (FFRs) to speech recordings in neonates (birth to 28 days). Method A systematic search of MeSH terms in the Cumulative Index to Nursing and Allied HealthLiterature, Embase, Google Scholar, Ovid Medline (R) and E-Pub Ahead of Print, In-Process & Other Non-Indexed Citations and Daily, Web of Science, SCOPUS, COCHRANE Library, and ClinicalTrials.gov was performed. Manual review of all items identified in the search was performed by two independent reviewers. Articles were evaluated based on the level of methodological quality and evidence according to the RTI item bank. Results Seven articles met inclusion criteria. None of the included studies reported neurodevelopmental outcomes past 3 months of age. Quality of the evidence ranged from moderate to high. Protocol variations were frequent. Conclusions Based on this systematic review, the FFR to speech can capture both temporal and spectral acoustic features in neonates. It can accurately be recorded in a fast and easy manner at the infant's bedside. However, at this time, further studies are needed to identify and validate which FFR features could be incorporated as an addition to standard evaluation of infant sound processing evaluation in subcortico-cortical networks. This review identifies the need for further research focused on identifying specific features of the neonatal FFRs, those with predictive value for early childhood outcomes to help guide targeted early speech and hearing interventions.

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Task-Switching Training and Transfer

Journal of Psychophysiology ◽

10.1027/0269-8803/a000189 ◽

2018 ◽

Vol 32 (3) ◽

pp. 106-130 ◽

Cited By ~ 5

Author(s):

Zsófia Anna Gaál ◽

István Czigler

Keyword(s):

Older Adults ◽

Young Adults ◽

Cognitive Training ◽

Task Switching ◽

Difficulty Level ◽

Training Procedure ◽

Far Transfer ◽

Near Transfer ◽

Related Potentials ◽

Transfer Tasks

Abstract. We used task-switching (TS) paradigms to study how cognitive training can compensate age-related cognitive decline. Thirty-nine young (age span: 18–25 years) and 40 older (age span: 60–75 years) women were assigned to training and control groups. The training group received 8 one-hour long cognitive training sessions in which the difficulty level of TS was individually adjusted. The other half of the sample did not receive any intervention. The reference task was an informatively cued TS paradigm with nogo stimuli. Performance was measured on reference, near-transfer, and far-transfer tasks by behavioral indicators and event-related potentials (ERPs) before training, 1 month after pretraining, and in case of older adults, 1 year later. The results showed that young adults had better pretraining performance. The reference task was too difficult for older adults to form appropriate representations as indicated by the behavioral data and the lack of P3b components. But after training older adults reached the level of performance of young participants, and accordingly, P3b emerged after both the cue and the target. Training gain was observed also in near-transfer tasks, and partly in far-transfer tasks; working memory and executive functions did not improve, but we found improvement in alerting and orienting networks, and in the execution of variants of TS paradigms. Behavioral and ERP changes remained preserved even after 1 year. These findings suggest that with an appropriate training procedure older adults can reach the level of performance seen in young adults and these changes persist for a long period. The training also affects the unpracticed tasks, but the transfer depends on the extent of task similarities.

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