scholarly journals Evaluation of the Frequency Following Response as a Predictive Biomarker of Response to Cognitive Training in Schizophrenia

2021 ◽  
Author(s):  
Peter E Clayson ◽  
Juan L Molina ◽  
Yash B. Joshi ◽  
Michael L. Thomas ◽  
Joyce Sprock ◽  
...  

Neurophysiological biomarkers of auditory processing show promise predicting outcomes following auditory-based targeted cognitive training (TCT) interventions in patients with schizophrenia, but the viability of the early frequency following response (FFR) as a biomarker has yet to be examined, despite its ecological and face validity for auditory-based interventions. FFR is an event-related potential (ERP) that reflects the earliest stages of auditory processing. We predicted that schizophrenia patients would show acute- and longer-term FFR malleability in the context of auditory-based TCT. Fifty-two schizophrenia patients were randomized to either TCT (n = 30) or treatment as usual (TAU; n = 22), and electroencephalography was recorded during rapid presentation of an auditory speech stimulus before treatment, after one hour of training, and after 30 hours of training. Patients in the TCT group did not show changes in FFR after training, but FFR measurements in the TAU group diminished over time. FFR was positively associated with performance on a measure of single word-in-noise perception in the TCT group, and with performance on a measure of sentence-in-noise perception in both TCT and TAU groups. Psychometric reliability analyses of FFR scores indicated high internal consistency but low test-rest reliability between sessions one hour and 12 weeks apart. While the present study did not find evidence of FFR malleability or utility in predicting response to auditory-based TCT, significant associations were observed between FFR measures and behavioral measures of speech discriminability. These findings support the dissociation between measures of speech discriminability along the hierarchy of cortical and subcortical early auditory information processing in schizophrenia.

2020 ◽  
Author(s):  
Peter E Clayson ◽  
Yash B. Joshi ◽  
Michael L. Thomas ◽  
Melissa Tarasenko ◽  
Andrew Bismark ◽  
...  

Deficits in early auditory information processing contribute to cognitive and psychosocial disability; this has prompted development of interventions that target low-level auditory processing, which may alleviate these disabilities. The frequency following response (FFR) is a constellation of event-related potential and frequency characteristics that reflect the processing of simple acoustic stimuli at the level of the brainstem and ascending portions of the auditory pathway. While FFR is a promising candidate biomarker of response to auditory-based cognitive training interventions, the psychometric properties of FFR in schizophrenia patients have not been studied. Here we assessed the internal consistency characteristics and magnitude of group differences across 18 different FFR parameters to determine which, if any, of these parameters demonstrate adequate internal consistency for use in intervention studies. Electroencephalography from 40 schizophrenia patients and 40 nonpsychiatric comparison subjects was recorded during rapid presentation of an auditory speech stimulus (6,000 trials). Patients showed normal response amplitudes but longer latencies for most FFR peaks and lower signal-to-noise ratios (SNRs) than healthy subjects. Analysis of amplitude and latency estimates of peaks, however, indicated a need for a substantial increase in task length to obtain internal consistency estimates above .80. In contrast, excellent internal consistency (> .95) was shown for FFR sustained responses. Only SNR scores reflecting the FFR sustained response yielded significant group differences and excellent internal consistency, suggesting that this measure is a viable candidate for use in clinical treatment studies. The present study highlights the use of internal consistency estimates of FFR to guide future intervention studies interested in individual differences among patients.


2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
M. Korostenskaja ◽  
K. Dapsys ◽  
A. Siurkute ◽  
A. Dudlauskaite ◽  
A. Pragaraviciene ◽  
...  

Abnormalities in attention, memory and information processing are considered to be the primary deficits in schizophrenia. Event-related potential (ERP) P300 could reflect deficits in auditory information processing related to active attention in schizophrenia patients. Atypical antipsychotics tend to ameliorate cognitive deficits, however their effects on neural aspects of cognitive dysfunction have not been consistent.Aim:To investigate the effects of quetiapine on auditory information processing by using auditory P300.Methods:We examined 7 patients with schizoaffective disorder, depressive type and 7 age- and sex-matched healthy controls. ERPs were elicited during active auditory “oddball” paradigm. P300 was recorded before and after two weeks of treatment with quetiapine (468.7±143 mg/day).Results:Baseline P300 latencies were significantly delayed in patients compared with controls. Quetiapine did not change P300 amplitudes. However, it normalized P300 latency. These results suggest that already after two weeks of treatment, quetiapine could have a beneficial effect on the active attention reflected in P300 in patients with schizoaffective disorder. Previous studies with antipsychotic drugs such as olanzapine and risperidone failed to show changes in P300 after this treatment interval.Conclusion:Quetiapine may be faster than other neuroleptics in ameliorating attentional dysfunction in patients with schizoaffective disorder. However, studies with a larger sample size must be conducted in order to confirm or reject the results of the current study.


2007 ◽  
Vol 18 (01) ◽  
pp. 034-053 ◽  
Author(s):  
Jeffrey Martin ◽  
James Jerger ◽  
Jyutika Mehta

Dichotic listening (DL) procedures are commonly employed in the evaluation of auditory processing in children. Review of the various clinical tests reveals considerable diversity in both the signals employed and their mode of administration. The extent to which other non auditory-specific factors influence the test outcome is often difficult to determine. Individual differences in memory, attention, facility with test stimuli, and report strategy are always of potential concern in the interpretation of results.In the present study, we examined behavioral and electrophysiological (ERP) responses for 20 children during two DL tasks. Two groups of children were evaluated. One group was comprised of children who showed substantial ear differences on clinical measures of DL; the other group showed no such deficits and served as age-matched controls. In one of the DL tasks, participants monitored dichotic stimuli using the divided-attention (unfocused) mode. In the other DL task, a directed-attention (focused) mode was employed. Both tasks involved simple "same-different" judgments for real words presented in a basic reference-probe paradigm. We purposefully sought an easy DL task in order to minimize the number of extra-auditory factors influencing their performance. For control purposes, a diotic procedure involving the same stimuli was also included.Results showed that the amplitude of the elicited late-positive component (LPC) was smaller and prolonged in latency for the group of poor listeners as compared to the control group. This finding occurred only when dichotic stimuli were presented in the divided-attention mode. When participants directed their attention to a single side, or when listening in a diotic mode, the LPC for both groups was more similar. Group differences in the N400 component were apparent for both listening tasks. Results are discussed in relation to an inability of some children to inhibit processing of unattended auditory information. Implications for the clinical administration of dichotic listening tests are also discussed. Los procedimientos de Audición Dicótica (DL) son comúnmente empleados en la evaluación del procesamiento auditivo en niños. La revisión de varias pruebas clínicas revela una diversidad considerable tanto en las señales empleadas como en su modo de administración. En qué grado otros factores no específicos de la audición influyen en los resultados de las pruebas es a menudo difícil de determinar. Las diferencias individuales en memoria, atención, facilidad con los estímulos de la prueba y la estrategia de reporte, tienen siempre influencia potencial en la interpretación de los resultados. En el presente estudio, examinamos respuestas conductuales y electrofisiológicas (ERP) en 20 niños con dos tareas de DL. Se evaluaron dos grupos de niños. Un grupo estaba constituido por niños que mostraban diferencias sustanciales entre los oídos en las mediciones clínicas de la DL; el otro grupo no mostró tal déficit y sirvieron como controles pareados por edad. En una de las tareas de DL, los participantes monitorearon estímulos dicóticos utilizando el modo de atención dividida (no concentrada). En la otra tarea de DL, se empleó un modo de atención dirigida (concentrada). Ambas tareas involucraron juicios simples de "igual-diferente" para palabras reales presentadas en un paradigma de sondeo de diferencia básica. A propósito, buscamos una tarea de DL fácil, para minimizar el número de factores extra-auditivos que influían en el desempeño. Para propósitos de control, se incluyó también un procedimiento diótico que utilizara los mismos estímulos. Los resultados muestran que la amplitud del componente positivo tardío (LPC) generado era más pequeña y más prolongada en latencia para el grupo de oyentes pobres comparado con el grupo control. Este hallazgo tuvo lugar sólo cuando se presentaron estímulos dicóticos en el modo de atención dividida. Cuando los participantes dirigieron su atención a un sólo lado, o cuando escucharon en un modo diótico, el LPC para ambos grupos fue similar. Las diferencias de grupo en el componente N400 fueron aparentes para ambas tareas de audición. Se discuten los resultados en relación con la incapacidad de algunos niños de inhibir el procesamiento de información auditiva a la que no se le está prestando atención. Se discuten las implicaciones para la administración clínicas de pruebas de audición dicótica.


2020 ◽  
Vol 215 ◽  
pp. 97-104 ◽  
Author(s):  
William C. Hochberger ◽  
Michael L. Thomas ◽  
Yash B. Joshi ◽  
Juan Molina ◽  
Emily B.H. Treichler ◽  
...  

2021 ◽  
pp. 114239
Author(s):  
Peter E. Clayson ◽  
Juan L. Molina ◽  
Yash B. Joshi ◽  
Michael L. Thomas ◽  
Joyce Sprock ◽  
...  

2002 ◽  
Vol 13 (08) ◽  
pp. 438-460 ◽  
Author(s):  
James Jerger ◽  
Linda Thibodeau ◽  
Jeffrey Martin ◽  
Jyutika Mehta ◽  
Gail Tillman ◽  
...  

We administered a battery of both behavioral and electrophysiologic measures to a pair of fraternal twin girls, one of whom exhibited symptoms consistent with an auditory processing disorder. Both twins were within normal limits on standardized tests of cognitive and language skills. Basic audiometric measures, as well as behavioral tests of simultaneous masking, backward masking, gap detection, and frequency-sweep discrimination, showed little difference between the twins. Significant differences, however, were evident on event-related potentials (ERPs) in response to both within-channel and across-channel gap detection tasks. Substantial differences were also noted for ERPs to both linguistic and nonlinguistic targets in dichotic listening paradigms. The pattern of electrophysiologic results was consistent with a deficit in the efficiency of interhemispheric transfer of auditory information. A possible reason for the greater effectiveness of electrophysiologic over behavioral measures is discussed.


2021 ◽  
Vol 12 ◽  
Author(s):  
Giulia M. Giordano ◽  
Francesco Brando ◽  
Andrea Perrottelli ◽  
Giorgio Di Lorenzo ◽  
Alberto Siracusano ◽  
...  

Background: Negative symptoms represent a heterogeneous dimension with a strong impact on functioning of subjects with schizophrenia (SCZ). Five constructs are included in this dimension: anhedonia, asociality, avolition, blunted affect, and alogia. Factor analyses revealed that these symptoms cluster in two domains: experiential domain (avolition, asociality, and anhedonia) and the expressive deficit (alogia and blunted affect), that might be linked to different neurobiological alterations. Few studies investigated associations between N100, an electrophysiological index of early sensory processing, and negative symptoms, reporting controversial results. However, none of these studies investigated electrophysiological correlates of the two negative symptom domains.Objectives: The aim of our study was to evaluate, within the multicenter study of the Italian Network for Research on Psychoses, the relationships between N100 and negative symptom domains in SCZ.Methods: Auditory N100 was analyzed in 114 chronic stabilized SCZ and 63 healthy controls (HCs). Negative symptoms were assessed with the Brief Negative Symptom Scale (BNSS). Repeated measures ANOVA and correlation analyses were performed to evaluate differences between SCZ and HCs and association of N100 features with negative symptoms.Results: Our findings demonstrated a significant N100 amplitude reduction in SCZ compared with HCs. In SCZ, N100 amplitude for standard stimuli was associated with negative symptoms, in particular with the expressive deficit domain. Within the expressive deficit, blunted affect and alogia had the same pattern of correlation with N100.Conclusion: Our findings revealed an association between expressive deficit and N100, suggesting that these negative symptoms might be related to deficits in early auditory processing in SCZ.


2019 ◽  
Vol 28 (4) ◽  
pp. 834-842
Author(s):  
Harini Vasudevan ◽  
Hari Prakash Palaniswamy ◽  
Ramaswamy Balakrishnan

Purpose The main purpose of the study is to explore the auditory selective attention abilities (using event-related potentials) and the neuronal oscillatory activity in the default mode network sites (using electroencephalogram [EEG]) in individuals with tinnitus. Method Auditory selective attention was measured using P300, and the resting state EEG was assessed using the default mode function analysis. Ten individuals with continuous and bothersome tinnitus along with 10 age- and gender-matched control participants underwent event-related potential testing and 5 min of EEG recording (at wakeful rest). Results Individuals with tinnitus were observed to have larger N1 and P3 amplitudes along with prolonged P3 latency. The default mode function analysis revealed no significant oscillatory differences between the groups. Conclusion The current study shows changes in both the early sensory and late cognitive components of auditory processing. The change in the P3 component is suggestive of selective auditory attention deficit, and the sensory component (N1) suggests an altered bottom-up processing in individuals with tinnitus.


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