Single dose testosterone administration modulates emotional reactivity and counterfactual choice in healthy males

Our aim was to investigate whether plasma l-arginine and asymmetric dimethylarginine (ADMA) concentrations and nitric oxide (NO) production are altered in male idiopathic hypogonadotropic hypogonadism (IHH) patients in the hypogonadal state and after single dose testosterone administration compared with those in control subjects. Eighteen newly diagnosed male patients with IHH and 20 healthy volunteer controls matched by age and body mass index were enrolled in the study. Single dose testosterone was administrated im. Initially, pretreatment blood samples were collected after overnight fasting. Posttreatment blood samples were drawn 10 d after the injection. ADMA, l-arginine, and NO were measured in pre- and posttreatment blood samples. The pretreatment ADMA and l-arginine levels were significantly higher, and plasma nitrite plus nitrate (NOx) levels were lower than those in the control group. After 10 d of treatment, ADMA and l-arginine levels were significantly reduced, and NOx levels were significantly increased. There was a significant positive correlation (P < 0.01) between ADMA and l-arginine and a negative correlation between ADMA and NOx levels in patients and controls. In conclusion, the patients with IHH showed elevated plasma ADMA levels associated with a reduction in NO production. Single dose parenteral T administration lowered ADMA concentrations and increased NO production to the control group values.

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Flow‐mediated dilation responses to exogenous testosterone administration in healthy males

The FASEB Journal ◽

10.1096/fasebj.27.1_supplement.1196.8 ◽

2013 ◽

Vol 27 (S1) ◽

Author(s):

Brett R Ely ◽

Jennifer A Miner ◽

Jonathon C Miner ◽

Paul F Kaplan ◽

Christopher T Minson

Keyword(s):

Flow Mediated Dilation ◽

Testosterone Administration ◽

Healthy Males

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Single Dose Pharmacokinetics of Metoclopramide Oral Tablets Utilizing HPLC-UV Method

Current Pharmaceutical Analysis ◽

10.2174/1573412914666180425123202 ◽

2019 ◽

Vol 15 (7) ◽

pp. 703-709 ◽

Cited By ~ 3

Author(s):

Iram Kaukab ◽

Syed Nisar Hussain Shah ◽

Ghulam Murtaza

Keyword(s):

Single Dose ◽

Area Under Curve ◽

Oral Formulation ◽

Gastrointestinal Disorders ◽

Published Data ◽

Maximum Plasma ◽

Open Label ◽

Oral Tablet ◽

Blood Samples ◽

Healthy Males

Background: Metoclopramide is a potent dopaminergic antagonist utilized for treating gastrointestinal disorders. The aim of this study was to examine the pharmacokinetics of oral formulation of metoclopramide in the Pakistani volunteers. Methods: This open label, single dose, pharmacokinetic study was executed in non-smoking, 12 Pakistani healthy males, treated with a single 20 mg oral tablet dose of metoclopramide on test day. Maximum plasma concentration (Cmax), time to achieve Cmax (Tmax), and area under curve (AUC0-t) of metoclopramide were determined analyzing the serial blood samples using a validated HPLC-UV method. Results: The determined values of Cmax, Tmax, and AUC0-t of metoclopramide were 34.51 ± 4.91 ng/ml, 1.56 ± 0.18 and 273.88 ± 114.49 ng.h/ml, respectively. Conclusion: The results reveal that the findings of Pakistani individuals are slightly different when compared with the published data of other ethnic origins.

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The Effect of Testosterone Administration and Digit Ratio (2D:4D) on Implicit Preference for Status Goods in Healthy Males

Frontiers in Behavioral Neuroscience ◽

10.3389/fnbeh.2017.00193 ◽

2017 ◽

Vol 11 ◽

Cited By ~ 5

Author(s):

Yin Wu ◽

Samuele Zilioli ◽

Christoph Eisenegger ◽

Luke Clark ◽

Hong Li

Keyword(s):

Digit Ratio ◽

Status Goods ◽

Testosterone Administration ◽

Healthy Males

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Testosterone modulates preattentive sensory processing and involuntary attention switches to emotional voices

Journal of Neurophysiology ◽

10.1152/jn.00587.2014 ◽

2015 ◽

Vol 113 (6) ◽

pp. 1842-1849 ◽

Cited By ~ 12

Author(s):

Chenyi Chen ◽

Chin-Yau Chen ◽

Chih-Yung Yang ◽

Chi-Hung Lin ◽

Yawei Cheng

Keyword(s):

Single Dose ◽

Sensory Processing ◽

Acute Effect ◽

Oddball Paradigm ◽

Involuntary Attention ◽

Double Blind ◽

Voice Perception ◽

Auditory Oddball ◽

Healthy Female ◽

Testosterone Administration

Testosterone is capable of altering facial threat processing. Voices, similar to faces, convey social information. We hypothesized that administering a single dose of testosterone would change voice perception in humans. In a placebo-controlled, randomly assigned, double-blind crossover design, we administered a single dose of testosterone or placebo to 18 healthy female volunteers and used a passive auditory oddball paradigm. The mismatch negativity (MMN) and P3a in responses to fearfully, happily, and neutrally spoken syllables dada and acoustically matched nonvocal sounds were analyzed, indicating preattentive sensory processing and involuntary attention switches. Results showed that testosterone administration had a trend to shorten the peak latencies of happy MMN and significantly enhanced the amplitudes of happy and fearful P3a, whereas the happy- and fearful-derived nonvocal MMN and P3a remained unaffected. These findings demonstrated acute effect of testosterone on the neural dynamics of voice perception. Administering a single dose of testosterone modulates preattentive sensory processing and involuntary attention switches in response to emotional voices.

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