Single dose testosterone administration enhances novelty responsiveness and short-term habituation in healthy males

Introduction: Radioactive iodine therapy (RAIT) in patients with hyperthyroidism (HT) causes apoptosis of thyrocytes to bring about restoration of thyroid function. The aim of the study was to find the short term extent of reduction of thyroid gland volume (TGV) by non-invasive quantitative assessment using ultrasound imaging (USG). Patients and Methods: This prospective study was conducted on a group of patients who had received RAIT due to primary hyperthyroidism at National Institute of Nuclear Medicine & Allied Sciences (NINMAS). Pre-therapy work up included hormone assay and baseline measurement of TGV by US before administration of appropriate fixed dose RAIT. Short term follow-up with hormone assay and serial measurements of TGV on two occasions were done at three and six months following the RAIT. Observed temporal changes of parameters were analyzed using appropriate statistics. Results: Total 117 patients with primary hyperthyroidism had received RAIT with diagnosis of diffuse toxic goiter in 86 patients, toxic multinodular goiter in 21 cases and single toxic nodular goiter in 10 cases. There was a decline of mean TGV from the baseline level of 24 ml to 14 ml at three months followed by a further decline to 9.1 ml at six months. Thus the volume reduction of thyroid gland was calculated to be 42% at three months and 62% at six months. The volume reduction was observed to be in a correlative trend with the normalization of hormone levels. The proportion of patients who showed persistent hyperthyroidism till the study end point was 23%. Conclusion: Single dose of radioactive iodine therapy resulted in reduction of TGV up to 62% till six months after RAIT while 23% patients showed persistent hyperthyroidism. The correlative trend of volume reduction with normalization of hormone levels indicates potentiality of TGV to emerge as an adjunct to conventional assessment of treatment efficacy following RAIT. Bangladesh J. Nuclear Med. 21(2): 87-91, July 2018

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Clodronate as a Single-dose Intravenous Infusion Effectively Provides Short-term Correction of Malignant Hypercalcemia

Acta Oncologica ◽

10.1080/02841860310013111 ◽

2003 ◽

Vol 42 (7) ◽

pp. 735-740 ◽

Cited By ~ 12

Author(s):

Sari T. Atula ◽

Riitta K. Tähtelä ◽

Jaakko I. Nevalainen ◽

Liisa H. Pylkkänen

Keyword(s):

Single Dose ◽

Intravenous Infusion ◽

Short Term

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Effect of short-term administration of garlic supplements on single-dose ritonavir pharmacokinetics in healthy volunteers

British Journal of Clinical Pharmacology ◽

10.1046/j.1365-2125.2003.01736.x ◽

2003 ◽

Vol 55 (2) ◽

pp. 199-202 ◽

Cited By ~ 77

Author(s):

Keith Gallicano ◽

Brian Foster ◽

Shurjeel Choudhri

Keyword(s):

Single Dose ◽

Healthy Volunteers ◽

Short Term ◽

Term Administration

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Short-term effects of single-dose chloral hydrate on neonatal auditory perception: An auditory event-related potential study

PLoS ONE ◽

10.1371/journal.pone.0212195 ◽

2019 ◽

Vol 14 (2) ◽

pp. e0212195

Author(s):

Qinfen Zhang ◽

Hongxin Li ◽

Xuan Dong ◽

Wenjuan Tu

Keyword(s):

Single Dose ◽

Auditory Perception ◽

Chloral Hydrate ◽

Event Related Potential ◽

Short Term ◽

Auditory Event ◽

Potential Study ◽

Short Term Effects

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Learning and Memory Impairment with Benzhexol

Australian & New Zealand Journal of Psychiatry ◽

10.3109/00048678709158932 ◽

1987 ◽

Vol 21 (4) ◽

pp. 612-614 ◽

Cited By ~ 3

Author(s):

Cherrie A. Galletly ◽

Colin D. Field

Keyword(s):

Single Dose ◽

Motor Skills ◽

Memory Impairment ◽

Short Term Memory ◽

Double Blind Trial ◽

Short Term ◽

Double Blind ◽

Term Memory ◽

New Learning ◽

Significant Impairment

A double-blind trial to determine the effects of a single dose of 2 mg benzhexol on cognitive functioning was undertaken using normal volunteers. Ninety minutes after the drug or placebo was taken, subjects completed a battery of psychological tests designed to measure learning, memory and motor skills. Benzhexol ingestion was associated with significant impairment of short-term memory and slowing of the rate of new learning.

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An open-label, single-dose bioavailability study of the pharmacokinetics of CAT-354 after subcutaneous and intravenous administration in healthy males

British Journal of Clinical Pharmacology ◽

10.1111/j.1365-2125.2010.03647.x ◽

2010 ◽

Vol 69 (6) ◽

pp. 645-655 ◽

Cited By ~ 41

Author(s):

Chad K. Oh ◽

Raffaella Faggioni ◽

Feng Jin ◽

Lorin K. Roskos ◽

Bing Wang ◽

...

Keyword(s):

Single Dose ◽

Intravenous Administration ◽

Open Label ◽

Bioavailability Study ◽

Healthy Males

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Elevated Plasma Concentration of Asymmetric Dimethylarginine That Is Reduced by Single Dose Testosterone Administration in Idiopathic Hypogonadotropic Hypogonadism Patients

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2004-2045 ◽

2005 ◽

Vol 90 (3) ◽

pp. 1651-1654 ◽

Cited By ~ 17

Author(s):

Erdinc Cakir ◽

Omer Ozcan ◽

Halil Yaman ◽

Emin Ozgur Akgul ◽

Cumhur Bilgi ◽

...

Keyword(s):

Single Dose ◽

Asymmetric Dimethylarginine ◽

Hypogonadotropic Hypogonadism ◽

Control Group ◽

No Production ◽

Elevated Plasma ◽

Idiopathic Hypogonadotropic Hypogonadism ◽

Blood Samples ◽

Testosterone Administration ◽

Plasma Nitrite

Our aim was to investigate whether plasma l-arginine and asymmetric dimethylarginine (ADMA) concentrations and nitric oxide (NO) production are altered in male idiopathic hypogonadotropic hypogonadism (IHH) patients in the hypogonadal state and after single dose testosterone administration compared with those in control subjects. Eighteen newly diagnosed male patients with IHH and 20 healthy volunteer controls matched by age and body mass index were enrolled in the study. Single dose testosterone was administrated im. Initially, pretreatment blood samples were collected after overnight fasting. Posttreatment blood samples were drawn 10 d after the injection. ADMA, l-arginine, and NO were measured in pre- and posttreatment blood samples. The pretreatment ADMA and l-arginine levels were significantly higher, and plasma nitrite plus nitrate (NOx) levels were lower than those in the control group. After 10 d of treatment, ADMA and l-arginine levels were significantly reduced, and NOx levels were significantly increased. There was a significant positive correlation (P < 0.01) between ADMA and l-arginine and a negative correlation between ADMA and NOx levels in patients and controls. In conclusion, the patients with IHH showed elevated plasma ADMA levels associated with a reduction in NO production. Single dose parenteral T administration lowered ADMA concentrations and increased NO production to the control group values.

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