Trans-synaptic degeneration of the optic radiation from optic nerve atrophy

Background: Optic radiation (OR) damage occurs in multiple sclerosis (MS). Objectives: The purpose of this study was to explore the contribution of local and distant mechanisms associated with OR damage in MS. Methods: Diffusion tensor (DT) magnetic resonance imaging (MRI) tractography probability maps of the ORs were derived from 102 MS patients and 11 controls. Between-group differences of OR normal-appearing white matter (NAWM) damage and topographical distribution of OR damage were assessed using quantitative and voxel-wise analyses, considering the influence of previous optic neuritis (ON+) and T2 OR lesions (T2 OR+). Results: OR NAWM diffusivity abnormalities were more severe in ON+ patients vs patients without previous optic neuritis (ON–) and T2 OR+ vs T2 OR– patients. Damage to the anterior portions of the ORs was more severe in ON+ vs ON– patients. Compared to controls and T2 OR– patients, T2 OR+ patients experienced a more distributed pattern of DT MRI abnormalities along the ORs, with an increased axial diffusivity limited to the anterior portions of the ORs. In T2 OR+ group, ON+ vs ON– patients showed DT MRI abnormalities in the middle portion of the ORs, in correspondence with focal lesions. OR damage correlated with OR T2 lesion volume, visual dysfunction and optic nerve atrophy. Conclusions: Both trans-synaptic degeneration secondary to optic nerve damage and Wallerian degeneration due to local T2 lesions contribute to OR damage in MS.

Download Full-text

Changes of Radial Diffusivity and Fractional Anisotopy in the Optic Nerve and Optic Radiation of Glaucoma Patients

The Scientific World JOURNAL ◽

10.1100/2012/849632 ◽

2012 ◽

Vol 2012 ◽

pp. 1-5 ◽

Cited By ~ 22

Author(s):

Tobias Engelhorn ◽

Georg Michelson ◽

Simone Waerntges ◽

Marlen Otto ◽

Ahmed El-Rafei ◽

...

Keyword(s):

Diffusion Tensor Imaging ◽

Optic Nerve ◽

Diffusion Tensor ◽

Regions Of Interest ◽

Optic Radiation ◽

Radial Diffusivity ◽

Optic Nerve Atrophy ◽

Temporal Contrast ◽

Mean Values ◽

Diffusion Tensor Imaging Dti

Purpose of this study was to evaluate with diffusion-tensor imaging (DTI) changes of radial diffusivity (RD) and fractional anisotropy (FA) in the optic nerve (ON) and optic radiation (OR) in glaucoma and to determine whether changes in RD and FA correlate with disease severity. Therefore, glaucoma patients and controls were examined using 3T. Regions of interest were positioned on RD and FA maps, and mean values were calculated for ON and OR and correlated with optic nerve atrophy and reduced spatial-temporal contrast sensitivity (STCS) of the retina. We found, that RD in glaucoma patients was significantly higher in the ON (0.74 ± 0.21 versus 0.58 ± 0.17⋅10−3 mm2 s−1;P<0.05) and OR (0.79 ± 0.23 versus 0.62 ± 0.14⋅10−3 mm2 s−1;P<0.05) compared to controls. Aside, FA was significantly decreased (0.48 ± 0.15 versus 0.66 ± 0.12 and 0.50 ± 0.20 versus 0.66 ± 0.11;P<0.05). Hereby, correlation between changes in RD/FA and optic nerve atrophy/STCS was observed (r>0.77). In conclusion, DTI at 3 Tesla allows robust RD and FA measurements in the ON and OR. Hereby, the extent of RD increase and FA decrease in glaucoma correlate with established ophthalmological examinations.

Download Full-text

Interstitial 12p deletion involving more than 40 genes in a patient with postnatal microcephaly, psychomotor delay, optic nerve atrophy, and facial dysmorphism

Meta Gene ◽

10.1016/j.mgene.2013.10.014 ◽

2014 ◽

Vol 2 ◽

pp. 72-82 ◽

Cited By ~ 3

Author(s):

Anne Hoppe ◽

Jan Heinemeyer ◽

Eva Klopocki ◽

Luitgard M. Graul-Neumann ◽

Birgit Spors ◽

...

Keyword(s):

Optic Nerve ◽

Facial Dysmorphism ◽

Optic Nerve Atrophy ◽

Psychomotor Delay

Download Full-text

A Case of Optic Nerve Atrophy with Severe Disc Cupping after Methanol Poisoning

Korean Journal of Ophthalmology ◽

10.3341/kjo.2011.25.2.146 ◽

2011 ◽

Vol 25 (2) ◽

pp. 146 ◽

Cited By ~ 8

Author(s):

Yong Woon Shin ◽

Ki Bang Uhm

Keyword(s):

Optic Nerve ◽

Optic Nerve Atrophy ◽

Methanol Poisoning

Download Full-text

OBSCURE CASES OF OPTIC NERVE ATROPHY OF CEREBRAL ORIGIN.

JAMA ◽

10.1001/jama.1896.02430970010001d ◽

1896 ◽

Vol XXVII (19) ◽

pp. 988

Author(s):

CHARLES W. KOLLOCK

Keyword(s):

Optic Nerve ◽

Optic Nerve Atrophy

Download Full-text

Combined corneal and optic nerve pathology

Russian ophthalmology of children ◽

10.25276/2307-6658-2021-1-28-32 ◽

2021 ◽

pp. 28-32

Author(s):

M.R. Khabazova ◽

◽

E.E. Ioyleva ◽

N.A. Gavrilova ◽

N.S. Gadzhieva ◽

...

Keyword(s):

Optic Nerve ◽

Corneal Dystrophy ◽

Diagnostic Methods ◽

Ophthalmological Examination ◽

Rare Occurrence ◽

Progressive Decrease ◽

Optic Nerve Atrophy ◽

Congenital Diseases ◽

Optic Disc Drusen ◽

Genetically Determined

A case with ophthalmological manifestations of two genetically determined diseases in one patient with a progressive decrease in visual functions is considered. The clinical picture and modern diagnostic methods necessary for the clinical diagnosis are reflected. The rare occurrence of combinations of congenital diseases of the cornea and optic nerve disc requires special attention during ophthalmological examination. Key words: corneal dystrophy, comorbidity, inherited diseases, optic nerve atrophy, optic disc drusen.

Download Full-text

Congenital optic disc coloboma

Russian ophthalmology of children ◽

10.25276/2307-6658-2021-1-33-39 ◽

2021 ◽

pp. 33-39

Author(s):

A.O. Nazarenko ◽

◽

E.E. Sidorenko ◽

D.V. Miguel ◽

A.S. Smartsev ◽

...

Keyword(s):

Differential Diagnosis ◽

Optic Nerve ◽

Clinical Picture ◽

Clinical Case ◽

Charge Syndrome ◽

Diagnostic Methods ◽

Newly Diagnosed ◽

Optic Nerve Atrophy ◽

Optic Disc Coloboma ◽

Optic Nerve Coloboma

A clinical case of observation of a 3-year-old child with a newly diagnosed optic nerve coloboma and multiple malformations is considered. The clinical picture and diagnostic methods necessary for the diagnosis are reflected. On the example of this child, the differential diagnosis with Charge syndrome is considered. Key words: coloboma, optic nerve coloboma, partial optic nerve atrophy, astigmatism, Charge syndrome.

Download Full-text