Epigenetic modulation of radiation response in human cancer cells with activated EGFR or HER-2 signaling: Potential role of histone deacetylase 6

2009 ◽  
Vol 92 (1) ◽  
pp. 125-132 ◽  
Author(s):  
In Ah Kim ◽  
Mina No ◽  
Jang Mi Lee ◽  
Jin Hee Shin ◽  
Jee Sun Oh ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Histone Deacetylase ◽  
Potential Role ◽  
Human Cancer ◽  
Radiation Response ◽  
Histone Deacetylase 6 ◽  
Human Cancer Cells ◽  
Her 2 ◽  
Epigenetic Modulation

scholarly journals Overexpression of Human ABCB1 and ABCG2 Reduces the Susceptibility of Cancer Cells to the Histone Deacetylase 6-Specific Inhibitor Citarinostat

2021 ◽  
Vol 22 (5) ◽  
pp. 2592
Author(s):  
Chung-Pu Wu ◽  
Cheng-Yu Hung ◽  
Sabrina Lusvarghi ◽  
Yen-Fu Chang ◽  
Sung-Han Hsiao ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Histone Deacetylase ◽  
Drug Transport ◽  
Human Cancer ◽  
Acquired Resistance ◽  
Specific Inhibitor ◽  
Clinical Effectiveness ◽  
Histone Deacetylase 6 ◽  
Multidrug Efflux ◽  
Human Cancer Cells

Citarinostat (ACY-241) is a promising oral histone deacetylase 6 (HDAC6)-selective inhibitor currently in clinical trials for the treatment of multiple myeloma (MM) and non-small-cell lung cancer (NSCLC). However, the inevitable emergence of resistance to citarinostat may reduce its clinical effectiveness in cancer patients and limit its clinical usefulness in the future. In this study, we investigated the potential role of the multidrug efflux transporters ABCB1 and ABCG2, which are two of the most common mechanisms of acquired resistance to anticancer drugs, on the efficacy of citarinostat in human cancer cells. We discovered that the overexpression of ABCB1 or ABCG2 significantly reduced the sensitivity of human cancer cells to citarinostat. We demonstrated that the intracellular accumulation of citarinostat and its activity against HDAC6 were substantially reduced by the drug transport function of ABCB1 and ABCG2, which could be restored by treatment with an established inhibitor of ABCB1 or ABCG2, respectively. In conclusion, our results revealed a novel mechanism by which ABCB1 and ABCG2 actively transport citarinostat away from targeting HDAC6 in cancer cells. Our results suggest that the co-administration of citarinostat with a non-toxic modulator of ABCB1 and ABCG2 may optimize its therapeutic application in the clinic.

Design, Synthesis, Structure−Selectivity Relationship, and Effect on Human Cancer Cells of a Novel Series of Histone Deacetylase 6-Selective Inhibitors

2007 ◽  
Vol 50 (22) ◽  
pp. 5425-5438 ◽  
Author(s):  
Yukihiro Itoh ◽  
Takayoshi Suzuki ◽  
Akiyasu Kouketsu ◽  
Nobuaki Suzuki ◽  
Satoko Maeda ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Histone Deacetylase ◽  
Human Cancer ◽  
Histone Deacetylase 6 ◽  
Selective Inhibitors ◽  
Design Synthesis ◽  
Human Cancer Cells

The Role of Sensing Peptides in the Cross-talk between Microbiota and Human Cancer Cells

2018 ◽  
Vol 18 (18) ◽  
pp. 1567-1571
Author(s):  
Anna Lucia Tornesello ◽  
Luigi Buonaguro ◽  
Maria Lina Tornesello ◽  
Franco M. Buonaguro
Keyword(s):  
Cancer Cells ◽  
Cross Talk ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
The Cross

scholarly journals In-Situ Description of the Role of PtdIns(3,4,5)P3 and PtdSer on PDK1 Regulation in Human Cancer Cells by Advanced Quantitative Microscopy

2014 ◽  
Vol 106 (2) ◽  
pp. 522a-523a
Author(s):  
Gloria de las Heras ◽  
Veronique Calleja ◽  
Banafshe Larijani ◽  
Jose Requejo-Isidro
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Quantitative Microscopy ◽  
Human Cancer Cells

scholarly journals Role of Bim in diallyl trisulfide-induced cytotoxicity in human cancer cells

2011 ◽  
Vol 112 (1) ◽  
pp. 118-127 ◽  
Author(s):  
Byeong-Chel Lee ◽  
Bae-Hang Park ◽  
Seog-Young Kim ◽  
Yong J. Lee
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Diallyl Trisulfide ◽  
Human Cancer Cells
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