Dose–volume histogram and dose–surface histogram analysis for skin reactions to carbon ion radiotherapy for bone and soft tissue sarcoma

PURPOSE: To evaluate the tolerance for and effectiveness of carbon ion radiotherapy in patients with unresectable bone and soft tissue sarcomas. PATIENTS AND METHODS: We conducted a phase I/II dose escalation study of carbon ion radiotherapy. Fifty-seven patients with 64 sites of bone and soft tissue sarcomas not suited for resection received carbon ion radiotherapy. Tumors involved the spine or paraspinous soft tissues in 19 patients, pelvis in 32 patients, and extremities in six patients. The total dose ranged from 52.8 to 73.6 gray equivalent (GyE) and was administered in 16 fixed fractions over 4 weeks (3.3 to 4.6 GyE/fraction). The median tumor size was 559 cm3 (range, 20 to 2,290 cm3). The minimum follow-up was 18 months. RESULTS: Seven of 17 patients treated with the highest total dose of 73.6 GyE experienced Radiation Therapy Oncology Group grade 3 acute skin reactions. Dose escalation was then halted at this level. No other severe acute reactions (grade > 3) were observed in this series. The overall local control rates were 88% and 73% at 1 year and 3 years of follow-up, respectively. The median survival time was 31 months (range, 2 to 60 months), and the 1- and 3-year overall survival rates were 82% and 46%, respectively. CONCLUSION: Carbon ion radiotherapy seems to be a safe and effective modality in the management of bone and soft tissue sarcomas not eligible for surgical resection, providing good local control and offering a survival advantage without unacceptable morbidity.

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Predictive factors of acute skin reactions to carbon ion radiotherapy for the treatment of malignant bone and soft tissue tumors

Radiation Oncology ◽

10.1186/s13014-017-0927-4 ◽

2017 ◽

Vol 12 (1) ◽

Cited By ~ 1

Author(s):

Yosuke Takakusagi ◽

Jun-ichi Saitoh ◽

Hiroki Kiyohara ◽

Takahiro Oike ◽

Shin-ei Noda ◽

...

Keyword(s):

Soft Tissue ◽

Predictive Factors ◽

Soft Tissue Tumors ◽

Carbon Ion Radiotherapy ◽

Skin Reactions ◽

Carbon Ion ◽

Acute Skin Reactions

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Dose-Volume Histogram Analysis for the Urethra to Predict Urinary Complications in Carbon-Ion Radiation Therapy of Prostate Cancer

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2014.05.1365 ◽

2014 ◽

Vol 90 (1) ◽

pp. S433

Author(s):

T. Yanagi ◽

H. Tsuji ◽

H. Ishikawa ◽

J. Shimazaki ◽

H. Tsujii ◽

...

Keyword(s):

Prostate Cancer ◽

Radiation Therapy ◽

Histogram Analysis ◽

Dose Volume Histogram ◽

Carbon Ion ◽

Dose Volume

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Carbon ion radiotherapy for unresectable localized axial soft tissue sarcoma

Cancer Medicine ◽

10.1002/cam4.1679 ◽

2018 ◽

Vol 7 (9) ◽

pp. 4308-4314 ◽

Cited By ~ 7

Author(s):

Reiko Imai ◽

Tadashi Kamada ◽

Nobuhito Araki ◽

Satoshi Abe ◽

Yukihide Iwamoto ◽

...

Keyword(s):

Soft Tissue ◽

Soft Tissue Sarcoma ◽

Carbon Ion Radiotherapy ◽

Carbon Ion

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Carbon ion radiotherapy for recurrent calf myxoid liposarcoma: a case report

Journal of International Medical Research ◽

10.1177/03000605211009701 ◽

2021 ◽

Vol 49 (4) ◽

pp. 030006052110097

Author(s):

Xiaojun Li ◽

Yanshan Zhang ◽

Yancheng Ye ◽

Ying Qi ◽

Chunlan Feng ◽

...

Keyword(s):

Soft Tissue ◽

Soft Tissue Sarcomas ◽

Myxoid Liposarcoma ◽

Ion Beams ◽

Carbon Ion Radiotherapy ◽

Irradiation Damage ◽

Radiation Dermatitis ◽

Complete Disappearance ◽

Carbon Ion ◽

The Right

Liposarcoma (LPS) is the most common soft tissue sarcoma. Myxoid LPS (MLPS) is the second most common subtype of LPS and accounts for 25% to 50% of all LPSs. Like most other soft tissue sarcomas, the mainstay of treatment for LPS is inevitably surgery. Multidisciplinary approaches, including surgery, chemotherapy, and radiotherapy, have been successful in the treatment of LPS during the last three decades. Even so, recurrence of LPS remains challenging. Carbon ion beams produce increased energy deposition at the end of their range to form a Bragg peak while minimizing irradiation damage to surrounding tissues, which facilitates more precise dosage and localization than that achieved with photon beams. Furthermore, carbon ion beams have high relative biologic effectiveness. We herein describe a patient who developed recurrent MLPS in the right calf after two surgeries and underwent carbon ion radiotherapy (CIRT), achieving complete disappearance of the tumor. The patient developed Grade 1 radiation dermatitis 30 days after CIRT, but no other acute toxicities were observed. The tumor had completely disappeared by 120 days after CIRT, and the patient remained disease-free for 27 months after CIRT. The CARE guidelines were followed in the reporting of this case.

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