Germline variants disrupting microRNAs predict long-term genitourinary toxicity after prostate cancer radiation

2022 ◽  
Author(s):  
Amar U. Kishan ◽  
Nicholas Marco ◽  
Melanie-Birte Schulz-Jaavall ◽  
Michael L. Steinberg ◽  
Phuoc T. Tran ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Germline Variants ◽  
Genitourinary Toxicity

scholarly journals Long-Term (10-Year) Gastrointestinal and Genitourinary Toxicity after Treatment with External Beam Radiotherapy, Radical Prostatectomy, or Brachytherapy for Prostate Cancer

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Grant K. Hunter ◽  
Chandana A. Reddy ◽  
Eric A. Klein ◽  
Patrick Kupelian ◽  
Kenneth Angermeier ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
External Beam Radiotherapy ◽  
External Beam ◽  
Genitourinary Toxicity

scholarly journals Randomized Trial Comparing Conventional-Dose With High-Dose Conformal Radiation Therapy in Early-Stage Adenocarcinoma of the Prostate: Long-Term Results From Proton Radiation Oncology Group/American College of Radiology 95-09

2010 ◽  
Vol 28 (7) ◽  
pp. 1106-1111 ◽  
Author(s):  
Anthony L. Zietman ◽  
Kyounghwa Bae ◽  
Jerry D. Slater ◽  
William U. Shipley ◽  
Jason A. Efstathiou ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radiation Therapy ◽  
Early Stage ◽  
Long Term Results ◽  
High Dose ◽  
Conventional Dose ◽  
Genitourinary Toxicity ◽  
Grade 3 ◽  
Dose Radiation

Purpose To test the hypothesis that increasing radiation dose delivered to men with early-stage prostate cancer improves clinical outcomes. Patients and Methods Men with T1b-T2b prostate cancer and prostate-specific antigen ≤ 15 ng/mL were randomly assigned to a total dose of either 70.2 Gray equivalents (GyE; conventional) or 79.2 GyE (high). No patient received androgen suppression therapy with radiation. Local failure (LF), biochemical failure (BF), and overall survival (OS) were outcomes. Results A total of 393 men were randomly assigned, and median follow-up was 8.9 years. Men receiving high-dose radiation therapy were significantly less likely to have LF, with a hazard ratio of 0.57. The 10-year American Society for Therapeutic Radiology and Oncology BF rates were 32.4% for conventional-dose and 16.7% for high-dose radiation therapy (P < .0001). This difference held when only those with low-risk disease (n = 227; 58% of total) were examined: 28.2% for conventional and 7.1% for high dose (P < .0001). There was a strong trend in the same direction for the intermediate-risk patients (n = 144; 37% of total; 42.1% v 30.4%, P = .06). Eleven percent of patients subsequently required androgen deprivation for recurrence after conventional dose compared with 6% after high dose (P = .047). There remains no difference in OS rates between the treatment arms (78.4% v 83.4%; P = .41). Two percent of patients in both arms experienced late grade ≥ 3 genitourinary toxicity, and 1% of patients in the high-dose arm experienced late grade ≥ 3 GI toxicity. Conclusion This randomized controlled trial shows superior long-term cancer control for men with localized prostate cancer receiving high-dose versus conventional-dose radiation. This was achieved without an increase in grade ≥ 3 late urinary or rectal morbidity.

scholarly journals Patient-reported genitourinary toxicity for long-term prostate cancer survivors treated with radiation therapy

2013 ◽  
Vol 108 (10) ◽  
pp. 1964-1970 ◽  
Author(s):  
C E Olsson ◽  
N Pettersson ◽  
D Alsadius ◽  
U Wilderäng ◽  
S L Tucker ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radiation Therapy ◽  
Cancer Survivors ◽  
Prostate Cancer Survivors ◽  
Genitourinary Toxicity ◽  
Patient Reported

8: Predictors of HRQOL Duirng Long-Term Follow-Up of Men Treated for Prostate Cancer

2007 ◽  
Vol 177 (4S) ◽  
pp. 3-4
Author(s):  
George J. Huang ◽  
Natalia Sadetsky ◽  
Peter R. Carroll ◽  
David F. Penson
Keyword(s):  
Prostate Cancer ◽  
Long Term Follow Up

201: Determinants of Mortality in Men with Prostate Cancer: How Important are Cancer Parameters on Long Term Survival?

2006 ◽  
Vol 175 (4S) ◽  
pp. 65-65
Author(s):  
Ashutosh K. Tewari ◽  
George Divine ◽  
Mani Menon
Keyword(s):  
Prostate Cancer ◽  
Term Survival ◽  
Long Term Survival

651: Long-Term Risk of Metastatic Progression of Prostate Cancer Following Radical Prostatectomy

2006 ◽  
Vol 175 (4S) ◽  
pp. 210-210
Author(s):  
Andrew J. Stephenson ◽  
James A. Eastham ◽  
Michael W. Kattan ◽  
Fernando J. Bianco ◽  
Zohar A. Dotan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Metastatic Progression

1461: Local Control and Long Term Disease Free Survival Following Radical Prostatectomy for D1 Prostate Cancer In The PSA ERA

2004 ◽  
Vol 171 (4S) ◽  
pp. 385-385 ◽  
Author(s):  
Carl K. Gjertson ◽  
Kevin P. Asher ◽  
Joshua D. Sclar ◽  
Aaron E. Katz ◽  
Erik T. Goluboff ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Local Control ◽  
Disease Free Survival ◽  
Free Survival ◽  
Disease Free
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