scholarly journals Transcription factor NRF2 uses the Hippo pathway effector TAZ to induce tumorigenesis in glioblastomas

Redox Biology ◽  
2020 ◽  
Vol 30 ◽  
pp. 101425 ◽  
Author(s):  
Maribel Escoll ◽  
Diego Lastra ◽  
Marta Pajares ◽  
Natalia Robledinos-Antón ◽  
Ana I. Rojo ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Hippo Pathway ◽  
The Hippo Pathway

DNA-binding mechanism of the Hippo pathway transcription factor TEAD4

Oncogene ◽  
2017 ◽  
Vol 36 (30) ◽  
pp. 4362-4369 ◽  
Author(s):  
Z Shi ◽  
F He ◽  
M Chen ◽  
L Hua ◽  
W Wang ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Dna Binding ◽  
Hippo Pathway ◽  
Binding Mechanism ◽  
The Hippo Pathway

scholarly journals Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis

2017 ◽  
Author(s):  
Jérôme Bohère ◽  
Alexandra Mancheno-Ferris ◽  
Kohsuke Akino ◽  
Yuya Yamabe ◽  
Sachi Inagaki ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Death ◽  
Transcription Factor ◽  
Adult Stem Cells ◽  
Hippo Pathway ◽  
Inhibitor Of Apoptosis ◽  
Hippo Signaling ◽  
Polished Rice ◽  
Organ Regeneration ◽  
The Hippo Pathway

AbstractTo compensate for accumulating damages and cell death, adult homeostasis (e.g., body fluids and secretion) requires organ regeneration, operated by long-lived stem cells. How stem cells can survive throughout the animal life yet remains poorly understood. Here we show that the transcription factor Shavenbaby (Svb, OvoL in vertebrates) is expressed in renal/nephric stem cells (RNSCs) ofDrosophilaand required for their maintenance during adulthood. As recently shown in embryos, Svb function in adult RNSCs further needs a post-translational processing mediated by Polished rice (Pri) smORF peptides and impairing Svb function leads to RNSC apoptosis. We show that Svb interacts both genetically and physically with Yorkie (YAP/TAZ in vertebrates), a nuclear effector of the Hippo pathway, to activate the expression of the inhibitor of apoptosisDIAP1. These data therefore identify Svb as a novel nuclear effector in the Hippo pathway, critical for the survival of adult somatic stem cells.

scholarly journals Parallel Activin and BMP signaling coordinates R7/R8 photoreceptor subtype pairing in the stochastic Drosophila retina

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Brent S Wells ◽  
Daniela Pistillo ◽  
Erin Barnhart ◽  
Claude Desplan
Keyword(s):  
Transcription Factor ◽  
Color Vision ◽  
Growth Regulator ◽  
Hippo Pathway ◽  
Bmp Signaling ◽  
Processing Factor ◽  
Activin Receptor ◽  
The Hippo Pathway ◽  
To Receive ◽  
Tgfβ Pathway

Drosophila color vision is achieved by comparing outputs from two types of color-sensitive photoreceptors, R7 and R8. Ommatidia (unit eyes) are classified into two subtypes, known as ‘pale’ or ‘yellow’, depending on Rhodopsin expression in R7 and R8. Subtype specification is controlled by a stochastic decision in R7 and instructed to the underlying R8. We find that the Activin receptor Baboon is required in R8 to receive non-redundant signaling from the three Activin ligands, activating the transcription factor dSmad2. Concomitantly, two BMP ligands activate their receptor, Thickveins, and the transcriptional effector, Mad. The Amon TGFβ processing factor appears to regulate components of the TGFβ pathway specifically in pale R7. Mad and dSmad2 cooperate to modulate the Hippo pathway kinase Warts and the growth regulator Melted; two opposing factors of a bi-stable loop regulating R8 Rhodopsin expression. Therefore, TGFβ and growth pathways interact in postmitotic cells to precisely coordinate cell-specific output.

scholarly journals Regulation of the Hippo Pathway Transcription Factor TEAD

2017 ◽  
Vol 42 (11) ◽  
pp. 862-872 ◽  
Author(s):  
Kimberly C. Lin ◽  
Hyun Woo Park ◽  
Kun-Liang Guan
Keyword(s):  
Transcription Factor ◽  
Hippo Pathway ◽  
The Hippo Pathway

scholarly journals The Ets Transcription Factor GABP Is a Component of the Hippo Pathway Essential for Growth and Antioxidant Defense

Cell Reports ◽  
2013 ◽  
Vol 3 (5) ◽  
pp. 1663-1677 ◽  
Author(s):  
Hongtan Wu ◽  
Yubo Xiao ◽  
Shihao Zhang ◽  
Suyuan Ji ◽  
Luyao Wei ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Antioxidant Defense ◽  
Hippo Pathway ◽  
Ets Transcription Factor ◽  
The Hippo Pathway

scholarly journals Lola regulates Drosophila adult midgut homeostasis via non-canonical hippo signaling

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Xue Hao ◽  
Shimin Wang ◽  
Yi Lu ◽  
Wentao Yu ◽  
Pengyue Li ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Stem Cell ◽  
Hippo Pathway ◽  
Tissue Homeostasis ◽  
Intestinal Stem Cell ◽  
Hippo Signaling ◽  
Intestinal Function ◽  
Independent Manner ◽  
The Hippo Pathway ◽  
Basal Proliferation

Tissue homeostasis and regeneration in the Drosophila midgut is regulated by a diverse array of signaling pathways including the Hippo pathway. Hippo signaling restricts intestinal stem cell (ISC) proliferation by sequestering the transcription co-factor Yorkie (Yki) in the cytoplasm, a factor required for rapid ISC proliferation under injury-induced regeneration. Nonetheless, the mechanism of Hippo-mediated midgut homeostasis and whether canonical Hippo signaling is involved in ISC basal proliferation are less characterized. Here we identify Lola as a transcription factor acting downstream of Hippo signaling to restrict ISC proliferation in a Yki-independent manner. Not only that Lola interacts with and is stabilized by the Hippo signaling core kinase Warts (Wts), Lola rescues the enhanced ISC proliferation upon Wts depletion via suppressing Dref and SkpA expressions. Our findings reveal that Lola is a non-canonical Hippo signaling component in regulating midgut homeostasis, providing insights on the mechanism of tissue maintenance and intestinal function.

scholarly journals YAP regulates cell size and growth dynamics via non-cell autonomous mediators

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Douaa Mugahid ◽  
Marian Kalocsay ◽  
Xili Liu ◽  
Jonathan Scott Gruver ◽  
Leonid Peshkin ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Cell Size ◽  
Cultured Cells ◽  
Hippo Pathway ◽  
Growth Dynamics ◽  
Cell Number ◽  
Hek293 Cells ◽  
Tissue Size ◽  
The Stability ◽  
The Hippo Pathway

The Hippo pathway regulates organ size, regeneration, and cell growth by controlling the stability of the transcription factor, YAP (Yorkie in Drosophila). When there is tissue damage, YAP is activated allowing the restoration of homeostatic tissue size. The exact signals by which YAP is activated are still not fully understood, but its activation is known to affect both cell size and cell number. Here we used cultured cells to examine the coordinated regulation of cell size and number under the control of YAP. Our experiments in isogenic HEK293 cells reveal that YAP can affect cell size and number by independent circuits. Some of these effects are cell autonomous, such as proliferation, while others are mediated by secreted signals. In particular CYR61, a known secreted YAP target, is a non-cell autonomous mediator of cell survival, while another unidentified secreted factor controls cell size.

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