Nonclinical safety evaluation of anticancer medicines for paediatric population (PP): A role for juvenile animal studies?

2011 ◽  
Vol 32 (2) ◽  
pp. 167
Author(s):  
Dinah M. Duarte ◽  
Beatriz Silva-Lima
Keyword(s):  
Animal Studies ◽  
Safety Evaluation ◽  
Paediatric Population ◽  
Juvenile Animal

The need for juvenile animal studies – A critical review

2013 ◽  
Vol 65 (1) ◽  
pp. 87-99 ◽  
Author(s):  
Liane Soellner ◽  
Klaus Olejniczak
Keyword(s):  
Critical Review ◽  
Animal Studies ◽  
Juvenile Animal

Value of juvenile animal studies

2011 ◽  
Vol 92 (4) ◽  
pp. 292-303 ◽  
Author(s):  
Isabelle Leconte ◽  
Graham Bailey ◽  
Karen Davis-Bruno ◽  
Kok Wah Hew ◽  
James Kim ◽  
...  
Keyword(s):  
Animal Studies ◽  
Juvenile Animal

scholarly journals Dobutamine in Paediatric Population: A Systematic Review in Juvenile Animal Models

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e95644 ◽  
Author(s):  
Victoria Mielgo ◽  
Adolf Valls i Soler ◽  
Carmen Rey-Santano
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Paediatric Population ◽  
Juvenile Animal

A Toxicology Databank Based on Animal Safety Evaluation Studies of Pharmaceutical Compounds

1985 ◽  
Vol 4 (4) ◽  
pp. 447-459 ◽  
Author(s):  
C.E. Lumley ◽  
S.R. Walker
Keyword(s):  
Animal Studies ◽  
Evaluation Studies ◽  
Safety Evaluation ◽  
Pharmaceutical Compounds ◽  
Pharmaceutical Companies ◽  
Animal Testing ◽  
Testing Procedures ◽  
Conventional Animal ◽  
Computer Based ◽  
Animal Safety

1 Thirteen UK pharmaceutical companies have provided comprehensive toxicological data from repeated-dose animal safety evaluation studies of 74 pharmaceutical compounds. 2 These data comprise a unique toxicology database and this paper describes its establishment including the problems encountered, its current size with over 35 000 data fields, its content and potential value for retrospective analyses. 3 Increasing reliance on animal studies for predicting the safety of medicines in man necessitates a reappraisal of conventional animal testing procedures and better use of the considerable volume of data in the archives of regulatory authorities and pharmaceutical companies. This reappraisal may be achieved by the use of computer-based toxicology databanks.

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