Body weight and auditory startle response in rat offspring permanently changed after reprogramming by diet and early exposure to MeHg

2011 ◽  
Vol 32 (2) ◽  
pp. 176-177
Author(s):  
Joantine Van Esterik ◽  
Celine De Esch ◽  
Reinier Kaiser ◽  
Henk Hendriks ◽  
Roderick Slieker ◽  
...  
Keyword(s):  
Body Weight ◽  
Startle Response ◽  
Early Exposure ◽  
Rat Offspring ◽  
Auditory Startle Response

scholarly journals Neonatal exposure to citalopram, a serotonin selective reuptake inhibitor, programs a delay in the reflex ontogeny in rats

2008 ◽  
Vol 66 (3b) ◽  
pp. 736-740 ◽  
Author(s):  
Teresa Cristina Bomfim de Jesus Deiró ◽  
Judelita Carvalho ◽  
Elizabeth do Nascimento ◽  
Jaiza Maria Barreto Medeiros ◽  
Fabiana Cajuhi ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Startle Response ◽  
Body Weight Gain ◽  
Behavioral Responses ◽  
Free Fall ◽  
Perinatal Period ◽  
The Body ◽  
Auditory Startle Response ◽  
Serotonin Selective Reuptake Inhibitor

Serotonin influences the growth and development of the nervous system, as well as its behavioral manifestations. The possibility exists that increased brain serotonin availability in young animals modulates their neuro-behavioral responses. This study investigated the body weight gain and reflex ontogeny of neonatal rats treated during the suckling period with two doses of citalopram (5 mg, or 10 mg/kg, sc, daily). The time of the appearance of reflexes (palm grasp righting, free-fall righting, vibrissa placing, auditory startle response, negative geotaxis and cliff avoidance) as well as the body weight evolution were recorded. In general, a delay in the time of reflex development and a reduced weight gain were observed in drug-treated animals. These findings suggest that serotoninergic mechanisms play a role in modulating body weight gain and the maturation of most reflex responses during the perinatal period in rats.

Prenatal exposure to glucocorticoids affects body weight, serum leptin levels, and hypothalamic neuropeptide‐Y expression in pre‐pubertal female rat offspring

2014 ◽  
Vol 36 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Takeshi Iwasa ◽  
Toshiya Matsuzaki ◽  
Munkhsaikhan Munkhzaya ◽  
Altankhuu Tungalagsuvd ◽  
Takako Kawami ◽  
...  
Keyword(s):  
Body Weight ◽  
Neuropeptide Y ◽  
Prenatal Exposure ◽  
Female Rat ◽  
Serum Leptin ◽  
Rat Offspring

Does Valproic Acid/Na Valproate Suppress Auditory Startle Reflex in Patients With Epilepsy?

2017 ◽  
Vol 49 (6) ◽  
pp. 407-413
Author(s):  
Meral E. Kızıltan ◽  
Leyla Köse Leba ◽  
Ayşegül Gündüz ◽  
Nevin Pazarcı ◽  
Çiğdem Özkara ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Startle Response ◽  
Healthy Subjects ◽  
Juvenile Myoclonic Epilepsy ◽  
Myoclonic Epilepsy ◽  
Lower Probability ◽  
Somatosensory Stimulation ◽  
Dopaminergic Transmission ◽  
Auditory Startle Response ◽  
Patients With Epilepsy

Background and Objective. Auditory startle response (ASR) was normal in juvenile myoclonic epilepsy whereas it was suppressed in progressive myoclonic epilepsy. However, both groups were using valproic acid/Na valproate (VPA) in different doses. Therefore, we aimed to analyze whether VPA has an impact on ASR in a cohort of epilepsy. For this purpose, we included patients with epilepsy and analyzed ASR in patients who were using VPA. Patients and Method. We included 51 consecutive patients who had epilepsy and were using VPA between January 2014 and January 2016. Two control groups of 37 epilepsy patients using other antiepileptic drugs (AEDs) and of 25 healthy subjects were also constituted. All participants underwent investigations of ASR and startle response to somatosensory inputs (SSS) under similar conditions. Results. An analysis of patients using VPA, not using VPA and healthy subjects revealed significantly longer latency and lower probability of orbicularis oculi (O.oc) and sternocleidomastoid responses after auditory stimulation, decreased total ASR probability and longer latency of O.oc response after somatosensory stimulation in patient groups compared with healthy subjects. Multivariate analysis showed type of AED had a role in the generation of abnormalities. VPA, carbamazepine, and multiple AED use caused suppression of ASR. Total ASR probability was decreased or O.oc latency got longer with longer duration of VPA use whereas serum VPA level at the time of investigation did not correlate with total ASR probability. Discussion. Both ASR and SSS are suppressed by the effect of VPA, especially in patients using for a long period and in patients using other AEDs with VPA. Given the fact that VPA leads to long-standing synaptic changes of dopaminergic transmission, abnormalities of this network may be the more likely cause.

Auditory Startle Response in Blind Subjects

1993 ◽  
Vol 76 (3_suppl) ◽  
pp. 1251-1256 ◽  
Author(s):  
Eytan Bachar ◽  
Tuvia Peri ◽  
Rachel Halamish ◽  
Arieh Y. Shalev
Keyword(s):  
Heart Rate ◽  
Skin Conductance ◽  
Rise Time ◽  
Startle Response ◽  
Pure Tone ◽  
Discriminative Learning ◽  
Habituation Rate ◽  
Auditory Startle Response ◽  
Blind Persons ◽  
Blind Individuals

Blindness is often associated with hypervigilance and arousal. The auditory startle response has been suggested as a measure of arousal. This study evaluated the auditory startle response of 10 blind individuals and 10 sighted controls who were exposed to a series of 15 1000-Hz, 95-db, 0-rise-time pure-tone stimuli, administered to both ears. The subjects' heart-rate, skin-conductance, and orbicularis-oculi-electromyogram responses to the tones were measured. Blind subjects did not differ from controls in the magnitude and in the habituation-rate of their responses. Results were interpreted as showing that blind persons' capacity for discriminative learning and for regulation of arousal is unimpaired. Task-related anxiety of blind persons should be differentiated from stimulus-related anxiety.

scholarly journals Effect of Predatory Stress Before Fertilization on Body Weight and Pentylenetetrazole-Induced Seizure in Rat Offspring

2020 ◽  
Vol 28 (127) ◽  
pp. 97-104
Author(s):  
Ehsan Saboory ◽  
Maryam Mahmoodkani ◽  
Shiva Roshan-Milani ◽  
Yousef Rasmi ◽  
◽  
...  
Keyword(s):  
Body Weight ◽  
Rat Offspring
Sign in / Sign up

Export Citation Format

Share Document