This paper presents a model-based exploration and policy analysis related to prostitution and prostitution-related human trafficking. After a brief introduction to prostitution and prostitution-related human trafficking, the paper zooms in on the Dutch situation. A System Dynamics simulation model related to the Dutch situation developed to explore and provide policy insights is subsequently presented. Using the simulation model, policies are first of all tested, and preliminary conclusions are drawn. These preliminary conclusions are further tested under deep uncertainty, using variants of the simulation models. The final conclusions are that supply side measures alone are counter-productive and that demand side measures are necessary but insufficient to solve prostitution-related human trafficking.