scholarly journals Transfusion restores blood viscosity and reinstates microvascular conditions from hemorrhagic shock independent of oxygen carrying capacity

Resuscitation ◽  
2007 ◽  
Vol 75 (1) ◽  
pp. 124-134 ◽  
Author(s):  
Pedro Cabrales ◽  
Marcos Intaglietta ◽  
Amy G. Tsai
Keyword(s):  
Hemorrhagic Shock ◽  
Carrying Capacity ◽  
Blood Viscosity ◽  
Oxygen Carrying Capacity

Effects of Venesection on Leg Blood Flow in Claudicants with High-Normal Haematocrit

1988 ◽  
Vol 33 (4) ◽  
pp. 298-299 ◽  
Author(s):  
A.R. Turner ◽  
G.D.O. Lowe ◽  
C.D. Forbes ◽  
J. G. Pollock
Keyword(s):  
Blood Flow ◽  
Intermittent Claudication ◽  
Carrying Capacity ◽  
Blood Viscosity ◽  
Oxygen Delivery ◽  
Peak Flow ◽  
Haemoglobin Concentration ◽  
Leg Blood Flow ◽  
Calf Blood Flow ◽  
Oxygen Carrying Capacity

Patients with intermittent claudication frequently have high-normal levels of haematocrit and hence blood viscosity, which may contribute to decreased calf blood flow on exercise, and hence to the symptom of claudication. Reduction in haematocrit and viscosity by serial venesection in eight patients with stable claudication and high-normal haematocrit (mean 0.50) was performed, and the effects on claudication, calf blood flow, and calf oxygen delivery were studied. Following reduction in haematocrit to low-normal levels (mean 0.44), resting calf blood flow was unchanged; peak flow after ischaemic exercise increased slightly (+17%), but peak oxygen delivery (peak flow × haemoglobin concentration) was unchanged. Hence any increase in calf blood flow in the symptomatic leg is balanced by a decrease in oxygen-carrying capacity after venesection. No increase in claudication time would therefore be expected, and none was observed in the present study.

scholarly journals Balance between oxygen transport and blood rheology during resuscitation from hemorrhagic shock with polymerized bovine hemoglobin

2020 ◽  
Vol 129 (1) ◽  
pp. 97-107
Author(s):  
Alexander T. Williams ◽  
Alfredo Lucas ◽  
Cynthia R. Muller ◽  
Crystal Bolden-Rush ◽  
Andre F. Palmer ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Hemorrhagic Shock ◽  
Oxygen Transport ◽  
Carrying Capacity ◽  
Blood Viscosity ◽  
Blood Rheology ◽  
Plasma Viscosity ◽  
Bovine Hemoglobin ◽  
Dependent Manner ◽  
Concentration Dependent Manner

Large-molecular diameter polymerized bovine hemoglobin avoided vasoconstriction and impairment of cardiac function during resuscitation from hemorrhagic shock that was seen with previous hemoglobin-based O2 carriers by increasing blood viscosity in a concentration-dependent manner. Supplementation of O2-carrying capacity played a smaller role in maintaining cardiac function than increased blood and plasma viscosity.

Haemorheology of the eastern grey kangaroo and the Tasmanian devil

2011 ◽  
Vol 59 (1) ◽  
pp. 26 ◽  
Author(s):  
Michael J. Simmonds ◽  
Oguz K. Baskurt ◽  
Herbert J. Meiselman ◽  
Michael Pyne ◽  
Michael Kakanis ◽  
...  
Keyword(s):  
Surface Charge ◽  
Carrying Capacity ◽  
Blood Viscosity ◽  
Haemoglobin Concentration ◽  
Scanning Electron Micrographs ◽  
Tasmanian Devil ◽  
Grey Kangaroo ◽  
Rbc Aggregation ◽  
Oxygen Carrying Capacity ◽  
Rbc Deformability

The blood of two Australian marsupials, the eastern grey kangaroo (Macropus giganteus) and the Tasmanian devil (Sarcophilus harrisii), has been reported to have greater oxygen-carrying capacity (i.e. haemoglobin content) when compared with that of placental mammals. We investigated whether alterations of blood rheological properties are associated with the increased oxygen-carrying capacity of these marsupials. Eastern grey kangaroos (n = 6) and Tasmanian devils (n = 4) were anaesthetised for blood sampling; human blood (n = 6) was also sampled for comparison. Laboratory measurements included blood and plasma viscosity, red blood cell (RBC) deformability, RBC aggregation and the intrinsic tendency of RBC to aggregate, RBC surface charge and haematological parameters. Scanning electron micrographs of RBC from each species provided morphological information. High-shear blood viscosity at native haematocrit was highest for the Tasmanian devil. When haematocrit was adjusted to 0.4 L L–1, lower-shear blood viscosity was highest for the eastern grey kangaroo. RBC deformability was greatly reduced for the Tasmanian devil. Eastern grey kangaroo blood had the highest RBC aggregation, whereas Tasmanian devil RBC did not aggregate. The surface charge of RBC for marsupials was ~15% lower than that of humans. The dependence of oxygen-delivery effectiveness on haemoglobin concentration (i.e. oxygen content) and blood viscosity was quantitated by calculating the haematocrit to blood viscosity ratio and was 15–25% lower for marsupials compared with humans. Our results suggest that environmental pressures since the marsupial–monotreme divergence have influenced the development of vastly different strategies to maintain a match between oxygen demand and delivery.

Variations in cardiac output associated with hemoglobin levels in anesthetized sheep

1965 ◽  
Vol 20 (1) ◽  
pp. 16-18 ◽  
Author(s):  
D. F. J. Halmagyi ◽  
B. Starzecki ◽  
G. J. Horner
Keyword(s):  
Cardiac Output ◽  
Carrying Capacity ◽  
Blood Viscosity ◽  
Cell Concentration ◽  
Wide Spectrum ◽  
Laboratory Animals ◽  
Normal Range ◽  
Pulmonary Arterial ◽  
Oxygen Carrying Capacity ◽  
Normal Laboratory

Hemoglobin levels in sheep was found to be related inversely to the logarithm of cardiac index and directly to the calculated systemic and pulmonary arterial resistances over a wide spectrum of hemoglobin concentrations including the normal range. It appeared to be based on changes in blood viscosity produced by a varying red cell concentration. The continuous adjustment of hemoglobin levels and cardiac output may account for the variability of cardiac output values in normal laboratory animals and may represent a mechanism maintaining oxygen delivery to the tissues in the presence of changing oxygen carrying capacity. blood viscosity; vascular resistance; oxygen carrying capacity Submitted on May 15, 1964

Layer-by-layer assembly of hemoglobin-coated microspheres for enhancing the oxygen carrying capacity

RSC Advances ◽  
2016 ◽  
Vol 6 (65) ◽  
pp. 59984-59987 ◽  
Author(s):  
Lijun Sun ◽  
Yannan Lu ◽  
Zhongqin Pan ◽  
Tingting Wu ◽  
Xiaojun Liu ◽  
...  
Keyword(s):  
Carrying Capacity ◽  
Layer By Layer ◽  
Layer By Layer Assembly ◽  
Oxygen Carrying Capacity ◽  
Layer Assembly

Hemoglobin-coated microspheres with one layer and five layers were fabricated by layer-by-layer assembly.

scholarly journals EVALUATION OF A STROMA-FREE HEMOGLOBIN SOLUTION FOR USE AS A PLASMA EXPANDER

1967 ◽  
Vol 126 (6) ◽  
pp. 1127-1142 ◽  
Author(s):  
S. Frederick Rabiner ◽  
J. Raymond Helbert ◽  
Harry Lopas ◽  
Lila H. Friedman
Keyword(s):  
Carrying Capacity ◽  
Vital Signs ◽  
Free Hemoglobin ◽  
Hemoglobin Solution ◽  
Plasma Expander ◽  
Chronic Effects ◽  
Coagulant Activity ◽  
Methemoglobin Formation ◽  
Oxygen Carrying Capacity ◽  
Acute And Chronic Effects

The preparation of large quantities of a stable, stroma-free hemoglobin solution without coagulant activity is described. Following infusion of this solution into phlebotomized dogs, there is no methemoglobin formation, no adverse effects on vital signs, and no demonstrable activation of blood coagulation. The hemoglobin maintains its oxygen-carrying capacity and liberates oxygen into tissues. Acute and chronic effects on renal function following infusion of this preparation were also studied and no effect on clearance of urea, creatinine, or P.A.H. could be demonstrated. There was no change in urinary output and histological sections revealed no lesions attributable to hemoglobin toxicity. It is concluded that a stroma-free hemoglobin solution may have use as a plasma expander.

Sign in / Sign up

Export Citation Format

Share Document