Immune restoration therapy for multidrug-resistant CMV disease in an allogenic stem cell transplant recipient

2022 ◽  
Vol 70 (2) ◽  
pp. 103329
Olivier Paccoud ◽  
Sophie Alain ◽  
Joel Gozlan ◽  
Sabrine Jarboui ◽  
David Boutolleau ◽  
2019 ◽  
Vol 220 (8) ◽  
pp. 1302-1306 ◽  
Jocelyne Piret ◽  
Manuel Schibler ◽  
Van Dung Pham ◽  
Sébastien Hantz ◽  
Federica Giannotti ◽  

AbstractWe report a case of cytomegalovirus encephalitis in a hematopoietic stem cell transplant recipient. A previously uncharacterized V787E mutation in UL54 was identified in cerebrospinal fluid but not plasma specimens. For the V787E recombinant virus, the half maximal effective concentrations for ganciclovir, foscarnet, and cidofovir were 8.6-, 3.4- and 2.9-fold higher than for wild-type virus, and the replicative capacity was lower. The introduction of a bulkier and negatively charged glutamate residue at position 787 could destabilize the finger domain of UL54 DNA polymerase. Viral genotyping of cerebrospinal fluid is warranted in subjects with cytomegalovirus encephalitis, owing to the low penetration of antivirals in this compartment.

2010 ◽  
Vol 56 (3) ◽  
pp. 495-497 ◽  
L. Nelson Sanchez-Pinto ◽  
Benjamin L. Laskin ◽  
Sonata Jodele ◽  
Trent R. Hummel ◽  
Hong J. Yin ◽  

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