Genetic component of autoimmune rheumatological diseases

Author(s):  
Daniela Juárez-Melchor ◽  
Pamela Munguía-Realpozo ◽  
Claudia Mendoza-Pinto ◽  
Ivet Etchegaray-Morales ◽  
Jorge Ayón-Aguilar ◽  
...  
Endocrines ◽  
2021 ◽  
Vol 2 (3) ◽  
pp. 171-184
Author(s):  
Filippo Egalini ◽  
Mirko Parasiliti Caprino ◽  
Giulia Gaggero ◽  
Vincenzo Cappiello ◽  
Jacopo Giannelli ◽  
...  

Autoimmune rheumatological diseases’ incidence and prevalence have risen over the last decades and they are becoming increasingly important worldwide. Thyroid autoimmune diseases share with them an imbalance in the immune system that lead to a pro-inflammatory environment. Usually this is the result of a multi-factorial process. In fact, it includes not only a possible genetic predisposition, but also environmental causes like microbiota dysbiosis, diet rich in processed foods, exposure to toxicants and infections. However, many aspects are currently under study. This paper aims to examine the factors that participate in the developing of rheumatological and thyroid autoimmune diseases. Moreover, as glucocorticoids still represent a leading treatment for systemic autoimmune rheumatological diseases, our secondary aim is to summarize the main effects of glucocorticoids treatment focusing on iatrogenic Cushing’s syndrome and glucocorticoids’ withdrawal syndrome.


Author(s):  
Robert M. Schindler ◽  
Vishal Lala ◽  
Jeanette E. Taylor
Keyword(s):  

2012 ◽  
Vol 15 (1) ◽  
pp. 21-33 ◽  
Author(s):  
Sven Oskarsson ◽  
Christopher Dawes ◽  
Magnus Johannesson ◽  
Patrik K. E. Magnusson

Recent studies have shown that trusting attitudes and behavior are biologically influenced. Focusing on the classic trust game, it has been demonstrated that oxytocin increases trust and that humans are endowed with genetic variation that influences their behavior in the game. Moreover, several studies have shown that a large share of the variation in survey responses to trust items is accounted for by an additive genetic component. Against this backdrop, this article makes two important contributions. First, utilizing a unique sample of more than 2,000 complete Swedish twin pairs, we provide further evidence of the heritability of social trust. Our estimates of the additive genetic component in social trust were consistent across the sexes – .33 for males and .39 for females – and are similar to the results reported in earlier studies. Secondly, we show that social trust is phenotypically related to three psychological traits – extraversion, personal control, and intelligence – and that genetic factors account for most of these correlations. Jointly, these psychological factors share around 30% of the genetic influence on social trust both for males and females. Future studies should further explore the possible causal pathways between genes and trust using panel data on both psychological traits and social trust.


2002 ◽  
Vol 91 (1) ◽  
pp. 231-232 ◽  
Author(s):  
J. Joseph
Keyword(s):  

The 2001 claim by Eigenberger and Sealander that “anti-imellectualism” has an important genetic component is discussed in reference to a rejoinder by Howley.


1976 ◽  
Vol 25 (1) ◽  
pp. 249-258 ◽  
Author(s):  
P. Propping ◽  
F. Vogel

It is the aim of twin studies to obtain results which are not only valid for twins, but apply to the whole population. Therefore the following questions have to be answered first: do twins differ from non-twins in the trait under study? Do different nongenetic factors act upon MZ and DZ twins which alter the probability of manifestation of a trait, even before birth? There are important differences in embryogenesis and placental blood flow in mono- and dichorionic twins; this can influence the normal fetal development. Therefore the value of twin studies alone in analysing the genetic component in the etiology of congenital malformations is rather ambiguous. Twin studies beyond the newborn period can be classified into four approaches: (1) Case reports; (2) Accumulated case reports; (3) Limited representative sample; (4) Unlimited representative sample. The most frequent systematic method in medical genetics is the establishment of all twins in a defined population of probands (3). Another successful application in the last few years has been in pharmacogenetics. Although no simple mode of inheritance could be discovered, it was possible to estimate the genetic component within the interindividual variability of the metabolism of certain drugs (nortriptyline, antipyrine, phenylbutazone, ethanol). Now, additional non-twin research is needed to work out single factors within the observed polygenic systems.


2021 ◽  
pp. 36-57
Author(s):  
Allison Ashley Koch ◽  
Evadnie Rampersaud
Keyword(s):  

2021 ◽  
pp. 1-3
Author(s):  
Diana M. Torpoco Rivera ◽  
Mina Hafzalah ◽  
Daniel J. Pomerantz ◽  
Richard U. Garcia

Abstract Dilated cardiomyopathy is the most common presentation of cardiomyopathy in children with 20–35% of patients having an identified genetic component. There are more than 30 genes implicated in the pathogenesis of dilated cardiomyopathy. We present the first report of a female infant with dilated cardiomyopathy with a genetic variant in the dispatched RND transporter family member 1 gene.


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