scholarly journals Situation of multidrug-resistant tuberculosis in the Czech Republic, unusual case study

2009 ◽  
Vol 2 (4) ◽  
pp. 185-188
Author(s):  
Vaclava Bartu ◽  
Emilie Kopecka
Keyword(s):  
Czech Republic ◽  
Unusual Case ◽  
Multidrug Resistant ◽  
The Czech Republic ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis

scholarly journals A Multidrug-Resistant Tuberculosis Microepidemic Caused by Genetically Closely Related Mycobacterium tuberculosis Strains

1999 ◽  
Vol 37 (8) ◽  
pp. 2715-2716 ◽  
Author(s):  
M. Kubín ◽  
M. Havelková ◽  
I. Hynčicová ◽  
Z. Švecová ◽  
J. Kaustová ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Fragment Length Polymorphism ◽  
Rflp Analysis ◽  
Multidrug Resistant ◽  
The Czech Republic ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Group A ◽  
Group B ◽  
Restriction Fragment Length

IS6110 DNA fingerprinting was used to characterize an outbreak of multidrug-resistant tuberculosis in 21 individuals (17 males and 4 females) living in or roaming among four distantly separated areas in the Czech Republic. The restriction fragment length polymorphism (RFLP) analysis separated the collectedMycobacterium tuberculosis strains into group A, including 14 patients with six IS6110 copies, and group B, with 7 patients displaying highly similar RFLP patterns but with two additional IS6110 bands. A switch from pattern A to pattern B was observed in one patient, and the subsequent detection of subclone B in seven more individuals has been explained by the instability of DNA genotypes caused by transposition of IS6110 elements.

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