48 – Psychometric evaluation of the Negative Symptom Assessment (NSA-16) scale in schizophrenic patients with predominant negative symptoms

Background: The long-term effects of dose reduction of atypical antipsychotics on cognitive function and symptomatology in stable patients with schizophrenia remain unclear. We sought to determine the change in cognitive function and symptomatology after reducing risperidone or olanzapine dosage in stable schizophrenic patients. Methods: Seventy-five stabilized schizophrenic patients prescribed risperidone (≥4 mg/day) or olanzapine (≥10 mg/day) were randomly divided into a dose-reduction group ( n=37) and a maintenance group ( n=38). For the dose-reduction group, the dose of antipsychotics was reduced by 50%; for the maintenance group, the dose remained unchanged throughout the whole study. The Positive and Negative Syndrome Scale, Negative Symptom Assessment-16, Rating Scale for Extrapyramidal Side Effects, and Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery were measured at baseline, 12, 28, and 52 weeks. Linear mixed models were performed to compare the Positive and Negative Syndrome Scale, Negative Symptom Assessment-16, Rating Scale for Extrapyramidal Side Effects and MATRICS Consensus Cognitive Battery scores between groups. Results: The linear mixed model showed significant time by group interactions on the Positive and Negative Syndrome Scale negative symptoms, Negative Symptom Assessment-16, Rating Scale for Extrapyramidal Side Effects, speed of processing, attention/vigilance, working memory and total score of MATRICS Consensus Cognitive Battery (all p<0.05). Post hoc analyses showed significant improvement in Positive and Negative Syndrome Scale negative subscale, Negative Symptom Assessment-16, Rating Scale for Extrapyramidal Side Effects, speed of processing, working memory and total score of MATRICS Consensus Cognitive Battery for the dose reduction group compared with those for the maintenance group (all p<0.05). Conclusions: This study indicated that a risperidone or olanzapine dose reduction of 50% may not lead to more severe symptomatology but can improve speed of processing, working memory and negative symptoms in patients with stabilized schizophrenia.

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Negative symptoms in bipolar disorder and schizophrenia: A psychometric evaluation of the brief negative symptom scale across diagnostic categories

Schizophrenia Research ◽

10.1016/j.schres.2015.12.014 ◽

2016 ◽

Vol 170 (2-3) ◽

pp. 285-289 ◽

Cited By ~ 21

Author(s):

Gregory P. Strauss ◽

Mary Vertinski ◽

Sally J. Vogel ◽

Erik N. Ringdahl ◽

Daniel N. Allen

Keyword(s):

Bipolar Disorder ◽

Negative Symptom ◽

Negative Symptoms ◽

Psychometric Evaluation ◽

Symptom Scale ◽

Diagnostic Categories

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The deficit syndrome in first-admission patients with psychotic and non-psychotic disorders

European Psychiatry ◽

10.1016/s0924-9338(97)89642-3 ◽

1997 ◽

Vol 12 (2) ◽

pp. 53-57 ◽

Cited By ~ 10

Author(s):

H Gerbaldo ◽

K Georgi ◽

D Pieschl

Keyword(s):

Negative Symptom ◽

Negative Symptoms ◽

Psychotic Disorders ◽

Deficit Syndrome ◽

Schizophrenic Patients ◽

First Admission

SummaryThe authors study the frequency of primary enduring negative symptoms in first-admission patients with schizophrenic and non-schizophrenic disorders. Carpenter's criteria for distinguishing the primary, enduring negative symptoms from the more transient negative symptoms (secondary to different factors) were applied. Furthermore, they compare negative symptom complexes between first-admission patients and patients with recurrent hospitalizations (within 5 years after first admission). There was a trend for patients with recurrent admissions to show more frequently a deficit syndrome than first-admission patients. Nevertheless, this difference was not significant (χ2 = 0.90). First-admission patients with deficit syndrome had significantly higher affective blunting (P < 0.05) and anhedonia (P < 0.001) than those with recurrent admissions. First-admission subjects with psychotic disorders had significantly higher frequency of deficit syndrome than those first-admission patients with non-psychotic disorders (P < 0.05). These results show that negative symptoms observed in first-admitted non-schizophrenic patients can also be enduring and primary. Thereby this work does not contribute to support the specificity of primary enduring negative symptoms for schizophrenia. Moreover, data suggest, that primary anhedonia and affective blunting can decrease within the first 5 years after discharge.

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S71. CLINICAL, BEHAVIOURAL AND NEURAL VALIDATION OF THE POSITIVE AND NEGATIVE SYMPTOM SCALE (PANSS) AMOTIVATION FACTOR

Schizophrenia Bulletin ◽

10.1093/schbul/sbaa031.137 ◽

2020 ◽

Vol 46 (Supplement_1) ◽

pp. S61-S61

Author(s):

Mariia Kaliuzhna ◽

Matthias Kirschner ◽

Fabien Carruzzo ◽

Matthias Hartmann ◽

Bischof Martin ◽

...

Keyword(s):

Factor Structure ◽

Negative Symptom ◽

Negative Symptoms ◽

Symptom Assessment ◽

Symptom Scale ◽

New Approach ◽

Reward Anticipation ◽

Two Factors ◽

Highly Correlated ◽

Assessment Scales

Abstract Background Negative symptoms of schizophrenia are suggested to map onto two distinct factors – amotivation and diminished expression, which relate to different aspects of behaviour and neural activity. Most research in patients with schizophrenia is conducted with broad symptom assessment scales, such as the PANSS, for which factor solutions allowing the distinction between amotivation and diminished expression have only recently been reported. We aimed to establish whether the PANSS factor structure corresponds to the well-established two-factor structure of the Brief Negative Symptom Scale (BNSS) and whether it allows distinguishing specific behavioural and neuronal correlates of amotivation. Methods In study 1 (N=120) we examined the correlations between the PANSS factors and the BNSS factors. In study 2 (N=31) we examined whether PANSS amotivation is specifically associated with reduced willingness to work for reward in an effort-based decision making task. In study 3 (N=43) we investigated whether PANSS amotivation is specifically correlated with reduced ventral striatal activation during reward anticipation using functional magnetic resonance imaging. Results On the clinical level, the PANSS amotivation and diminished expression were highly correlated with their BNSS counterparts. On the behavioural level, PANSS amotivation factor but not the diminished expression factor was specifically associated with reduced willingness to invest effort to obtain a reward. On the neural level, PANSS amotivation was specifically associated with ventral striatal activation during reward anticipation. Discussion Our data confirm that the two domains of negative symptoms can be measured with the PANSS and are linked to specific aspects of behaviour and brain function. To our knowledge, this is the first study employing behavioural and neural measures to validate a new approach to clinical measurement of negative symptoms. Our results warrant a re-analysis of previous work that used the PANSS to further substantiate the distinction between the two factors in behavioural and neuroimaging studies.

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Comparison of negative symptoms in schizophrenic and poor outcome bipolar patients

Psychological Medicine ◽

10.1017/s0033291700030300 ◽

1992 ◽

Vol 22 (2) ◽

pp. 361-365 ◽

Cited By ~ 11

Author(s):

Ravinder Reddy ◽

Sukdeb Mukherjee ◽

David B. Schnur

Keyword(s):

Negative Symptom ◽

Negative Symptoms ◽

Symptom Dimensions ◽

Chronic Schizophrenic ◽

Poor Outcome ◽

Relative Specificity ◽

Schizophrenic Patients ◽

Bipolar Patients ◽

Manic Patients ◽

Affective Flattening

SYNOPSISUsing the Scale for the Assessment of Negative Symptoms (SANS), affective blunting, alogia, and attentional impairment were assessed in 30 manic patients with chronic impairment of inter-episode instrumental functioning and 85 chronic schizophrenic patients. The schizophrenic patients had markedly higher ratings on all three negative symptom dimensions. When negative symptoms were examined categorically, no manic patient was rated to show prominent affective flattening or alogia. This relative specificity may not apply to attentional impairment which was rated as prominent in 17% of the manic patients and in 55% of the schizophrenic patients.

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The Positive: Negative Dichotomy in Schizophrenia

The British Journal of Psychiatry ◽

10.1192/bjp.157.1.41 ◽

1990 ◽

Vol 157 (1) ◽

pp. 41-49 ◽

Cited By ~ 65

Author(s):

A. M. Mortimer ◽

C. E. Lund ◽

P. J. McKenna

Keyword(s):

Cognitive Impairment ◽

Negative Symptom ◽

Negative Symptoms ◽

Thought Disorder ◽

Motor Disorder ◽

Positive Symptoms ◽

Formal Thought Disorder ◽

Symptom Scores ◽

Schizophrenic Patients ◽

Positive And Negative Symptoms

Two studies are reported. In the first, of 62 schizophrenic patients, no correlation between negative symptom scores (rated blindly) and any measure of positive symptoms was found. This independence was confirmed by factor and cluster analyses, which left the question of a third ‘disorganisation’ class of schizophrenic symptoms open. In the second study, of 80 patients, formal thought disorder separated unequivocally into ‘positive formal thought disorder’ and ‘alogia’ syndromes on the basis of correlations with positive and negative symptoms. Catatonic motor disorder also showed evidence of a corresponding positive: negative division, although this only emerged when severity or chronicity of illness was controlled for. Cognitive impairment showed a broad range of affiliations and its particular correlation with negative symptoms was perhaps artefactual.

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Relationship between Neuroleptic Dose and Positive and Negative Symptoms

Psychological Reports ◽

10.2466/pr0.1994.74.2.481 ◽

1994 ◽

Vol 74 (2) ◽

pp. 481-482 ◽

Cited By ~ 2

Author(s):

Patrick B. Johnson ◽

Lewis A. Opler ◽

Paul M. Ramirez ◽

Robert Malgady

Keyword(s):

Side Effects ◽

Negative Symptom ◽

Negative Symptoms ◽

Zero Order ◽

Standardized Assessments ◽

Symptom Scores ◽

Medication Dose ◽

Schizophrenic Patients ◽

Positive And Negative Symptoms

The present study explored possible connections between neuroleptic dose and the positive and negative symptoms of schizophrenic patients. Zero-order correlations between medication dose as measured in CPZ equivalent units and standardized assessments of positive (hallucinations, delusions) and negative (blunted affect, poor rapport) symptoms were carried out on 28 hospitalized schizophrenics. While dose was positively related to over-all negative symptom scores as well as specific negative symptoms, no relation was found with positive scores. The discussion focused on the possibility that negative symptoms might represent medication-induced side effects and the need for further research.

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A Study of the Characteristics of the White Matter in Schizophrenic Patients with Defective or Non-defective Symptoms by Diffuse Tensor Imaging

10.21203/rs.3.rs-26837/v1 ◽

2020 ◽

Author(s):

Wen-jie Shi ◽

Tai-peng Sun ◽

Li-rong Zhuang ◽

Hua Feng ◽

Peng Yan ◽

...

Keyword(s):

White Matter ◽

Corpus Callosum ◽

Diagnostic Criteria ◽

Symptom Score ◽

Negative Symptom ◽

Negative Symptoms ◽

Structural Integrity ◽

Imaging Data ◽

Schizophrenic Patients ◽

The Right

Abstract BackgroundDeficit schizophrenia (DS) is a set of highly homogenous schizophrenia subtypes characterized by primary and persistent negative symptoms. Previous research studies have found that the negative symptoms of schizophrenia are closely related to the impairment of brain structure and function.This study seeks to explore the characteristics of white matter in schizophrenic patients with defective or non-defective symptoms by diffuse tensor imaging (DTI).MethodsAccording to the defective schizophrenia diagnostic criteria and ICD-10 diagnostic criteria, 30 patients with DS and 30 patients with non-defective schizophrenia (NDS) were enrolled into the research study. DTI imaging data of the white matter were collected by 1.5T magnetic resonance imaging scanner. Then a tract-based spatial statistics (TBSS) method was used to compare the fractional anisotropy (FA) values of the white matter fiber between the two groups.ResultsThe TBSS analysis results showed that the FA values in the right side of the knee of the corpus callosum (MNI:14,36,-7), right anterior radio-coronal region (MIN:11,34,3) and the right hippocampal region (MIN:30,34,16) in the DS patients were significantly lower compared with those of the NDS patients (all p<0.05). The FA values in the right side of the knee of the corpus callosum was significantly correlated with the time from onset to treatment (r=−0.350, p<0.001), PANSS-negative symptom score (r=−0.157, p=0.007). The FA values in the right anterior radio-crown region was positively correlated with PANSS-negative symptom score (r=0.306, p=0.048). The right hippocampus was negatively correlated with years of education (r=−0.614, p=0.020), duration of antipsychotics using(r=−0.140, p= 0.022), and PANSS-negative symptom score (r=−0.637, p=0.040).ConclusionsIn schizophrenic patients with defective symptoms, the structural integrity of white matter fibers was more seriously damaged in the three brain regions including the right knee of the corpus callosum, the right anterior region of the right radiative crown, and the right hippocampus. These white matter lesions are closely related to patient characteristics such as years of education, duration from onset to treatment, duration of anti-psychotic, and severity of negative symptoms.

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