Glycinamide prevents MK-801-induced hyperactivity and deficits in object recognition memory in an animal model of positive and cognitive symptoms of schizophrenia

2015 ◽  
Vol 166 (1-3) ◽  
pp. 349-350 ◽  
Author(s):  
Enrique Basurto ◽  
Oscar González Flores ◽  
Kurt Leroy Hoffman
Author(s):  
Vidya Shree Vinay ◽  
Malathi S ◽  
Ravindran R

ABSTRACTObjective: Acetylcholinesterase (AChE) inhibitors are important therapeutic targets to treat memory impairment caused due to stress, post-traumaticstress disorder (PTSD) results from traumatic stress exposure. Cognition and mood symptoms can begin or worsen after the traumatic event. In thisstudy, we aimed to evaluate the role of Eclipta alba Linn. as an antistressor, AChE inhibitor, and on object recognition memory in an animal model of PTSD.Methods: Adult male Wistar albino rats were randomly divided into four groups: Control, chronic unpredictable stress (CUS) (30 days), CUS+ethanolicextract of E. alba (EEEA) (200 mg/kg body weight), and EEEA (200 mg/kg body weight) treatment groups and were assessed for novel objectrecognition task (NORT), plasma corticosterone, and AChE activity.Results: We found significant improvement in NORT (p<0.05) plasma corticosterone levels in stress group was significantly increased (p<00.05)which is resumed with EEEA treatment (p<0.05) AChE activity was found to be reduced after EEEA treatment.Conclusion: EEEA is found to possess cognitive enhancing activity in the animal model of PTSD.Keywords: Recognition memory,PTSD,Unpredictable stress,Eclipta alba


2005 ◽  
Vol 156 (1) ◽  
pp. 139-143 ◽  
Author(s):  
Maria Noêmia M. de Lima ◽  
Daniela C. Laranja ◽  
Elke Bromberg ◽  
Rafael Roesler ◽  
Nadja Schröder

2021 ◽  
Vol 187 ◽  
pp. 108493
Author(s):  
Gerardo Ramirez-Mejia ◽  
Elvi Gil-Lievana ◽  
Oscar Urrego-Morales ◽  
Ernesto Soto-Reyes ◽  
Federico Bermúdez-Rattoni

2010 ◽  
Vol 207 (1) ◽  
pp. 44-50 ◽  
Author(s):  
Patricia Jurado-Berbel ◽  
David Costa-Miserachs ◽  
Meritxell Torras-Garcia ◽  
Margalida Coll-Andreu ◽  
Isabel Portell-Cortés

2012 ◽  
Vol 88 (4) ◽  
pp. 385-391 ◽  
Author(s):  
Luciana Estefani Drumond ◽  
Flávio Afonso Gonçalves Mourão ◽  
Hércules Ribeiro Leite ◽  
Renata Viana Abreu ◽  
Helton José Reis ◽  
...  

2017 ◽  
Vol 142 ◽  
pp. 79-84 ◽  
Author(s):  
Andressa Radiske ◽  
Janine I. Rossato ◽  
Maria Carolina Gonzalez ◽  
Cristiano A. Köhler ◽  
Lia R. Bevilaqua ◽  
...  

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