Verbal memory measurement towards digital perspectives in first-episode psychosis: A review

Objective: Early intervention in patients with first episode psychosis (FEP) can improve cognitive abilities, with both short- and long-term benefits. In this paper, we describe the implementation and review of cognitive remediation training (CRT) in an Asian FEP population. The outcomes of the training are also evaluated and discussed.Methods: This naturalistic paper describes in detail the real-life implementation and conduct of CRT in an early psychosis intervention service. One hundred and nine patients with FEP underwent a 24-session CRT programme, using Cogpack and Neuropsychological Educational Approach to Remediation. The program is evaluated with pre- and post-CRT assessment scores which included Montreal Cognitive Assessment and Brief Assessment of Cognition in Schizophrenia. The rates of improvement on these cognitive assessments were evaluated using paired t-tests, with statistical significance set at p ≤ 0.05.Results: Of the 109 patients who underwent CRT, a total of 92 (84.4%) completed all 24 sessions. Paired t-tests between pre- and post-CRT assessments scores revealed that participants significantly improved on majority of the measures, including verbal memory, digit sequencing, and symbol coding.Conclusion: As with other cognitive remediation programmes, CRT has shown to improve cognitive functioning in patients with FEP. The results support the use of CRT in an Asian context and may serve as guidance for the implementation of similar training programmes in other Asian early psychosis intervention services.

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T34. DECREASED STRUCTURAL CONNECTIVITY IN FIRST-EPISODE PSYCHOSIS IN A VERBAL MEMORY NETWORK DERIVED FROM PARTIAL LEAST SQUARES REGRESSION

Schizophrenia Bulletin ◽

10.1093/schbul/sbz019.314 ◽

2019 ◽

Vol 45 (Supplement_2) ◽

pp. S216-S216

Author(s):

Katie Lavigne ◽

Carolina Makowski ◽

Alan Evans ◽

Martin Lepage

Keyword(s):

Least Squares ◽

Partial Least Squares ◽

Verbal Memory ◽

Partial Least Squares Regression ◽

Structural Connectivity ◽

First Episode Psychosis ◽

First Episode ◽

Least Squares Regression ◽

Episode Psychosis ◽

Memory Network

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Impairment in verbal memory observed in first episode psychosis patients with persistent negative symptoms

Schizophrenia Research ◽

10.1016/j.schres.2013.04.006 ◽

2013 ◽

Vol 147 (2-3) ◽

pp. 223-229 ◽

Cited By ~ 17

Author(s):

Cindy L. Hovington ◽

Michael Bodnar ◽

Ridha Joober ◽

Ashok K. Malla ◽

Martin Lepage

Keyword(s):

Verbal Memory ◽

Negative Symptoms ◽

First Episode Psychosis ◽

First Episode ◽

Episode Psychosis ◽

Persistent Negative Symptoms

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Cognitive markers of short-term clinical outcome in first-episode psychosis

The British Journal of Psychiatry ◽

10.1192/bjp.bp.107.040410 ◽

2008 ◽

Vol 193 (4) ◽

pp. 297-304 ◽

Cited By ~ 30

Author(s):

Michael Bodnar ◽

Ashok Malla ◽

Ridha Joober ◽

Martin Lepage

Keyword(s):

Clinical Outcome ◽

Verbal Memory ◽

Psychotic Disorders ◽

First Episode Psychosis ◽

First Episode ◽

Short Term ◽

Cognitive Domains ◽

Good Outcome ◽

Poor Outcome ◽

Episode Psychosis

BackgroundOutcome from psychotic disorders is heterogeneous with poorer outcomes frequently identified too late to be influenced. Symptomatic ratings at 1 or more years following initiation of treatment have been related to cognition in firstepisode psychosis. However, the relationship between cognition and early outcome remains unclear.AimsTo determine whether specific cognitive domains could identify poor short-term outcome among individuals with first-episode psychosis.MethodOne hundred and fifty-one individuals with first-episode psychosis were divided into two groups based on 6-month clinical data after the initiation of treatment. Six cognitive domains were compared among 78 participants with poor outcomes, 73 with good outcomes and 31 healthy controls.ResultsLower performance on verbal memory (z-scores: poor outcome=–1.3 (s.d.=1.1); good outcome=–0.8 (s.d.=0.9); P=0.001) and working memory (poor outcome=–1.0 (s.d.=1.2); good outcome=–0.4 (s.d.=0.9); P=0.003) identified individuals with first-episode psychosis with a poor outcome after 6 months of treatment.ConclusionsThe early identification of those individuals with first-episode psychosis with a poor clinical outcome may encourage clinicians to pay special attention to them in the form of alternative pharmacological and psychological treatments for a more favourable outcome in the long term.

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Verbal memory improvement in first-episode psychosis APOE-ε4 carriers: a pleiotropic effect?

Neuropsychiatric Disease and Treatment ◽

10.2147/ndt.s150488 ◽

2017 ◽

Vol Volume 13 ◽

pp. 2945-2953 ◽

Cited By ~ 4

Author(s):

Fidel Vila-Rodriguez ◽

Donna Lang ◽

Heather Baitz ◽

Kristina Gicas ◽

Allen Thornton ◽

...

Keyword(s):

Verbal Memory ◽

Pleiotropic Effect ◽

First Episode Psychosis ◽

First Episode ◽

Memory Improvement ◽

Episode Psychosis

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966. Cortical Gray-White Matter Contrast Underlying Negative Symptoms and Verbal Memory in First Episode Psychosis

Biological Psychiatry ◽

10.1016/j.biopsych.2017.02.692 ◽

2017 ◽

Vol 81 (10) ◽

pp. S391

Author(s):

Carolina Makowski ◽

John D. Lewis ◽

Claude Lepage ◽

Ashok K. Malla ◽

Ridha Joober ◽

...

Keyword(s):

White Matter ◽

Verbal Memory ◽

Negative Symptoms ◽

First Episode Psychosis ◽

First Episode ◽

Episode Psychosis

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Oxidative stress, inflammation and cognitive impairment in first psychotic patients

European Psychiatry ◽

10.1016/s0924-9338(11)72134-4 ◽

2011 ◽

Vol 26 (S2) ◽

pp. 427-427

Author(s):

M. Martínez-Cengotitabengoa ◽

J.C. Leza ◽

S. Alberich ◽

S. Barbeito ◽

R. González-Oliveros ◽

...

Keyword(s):

Oxidative Stress ◽

Nitric Oxide ◽

Cognitive Impairment ◽

Cognitive Functioning ◽

Verbal Memory ◽

First Episode Psychosis ◽

First Episode ◽

Healthy Controls ◽

Episode Psychosis ◽

Activity Of Enzymes

IntroductionBoth oxidative stress and the inflammatory chemokine MCP-1 have been linked to the pathophysiology of certain mental illnesses such as psychosis. There are previous studies in rats and dogs suggesting that oxidative stress can cause cognitive impairment.ObjectivesTo correlate oxidative stress and the chemokine MCP-1 levels with cognitive impairment in first episode psychosis.Methods28 patients with first episode psychosis and 28 healthy controls matched by sex and age were included in the study, who were given a battery of neurocognitive tests and we determined their blood levels of lipid peroxidation (TBARS), nitric oxide, total antioxidant status (TAS), glutathione, activity of enzymes catalase (CAT), glutathione peroxidase (cGPx) and superoxide dismutase (SOD) and the inflammatory chemokine MCP-1.ResultsHealthy controls had better TAS than patients and increased activity of enzymes cGPx and CAT.We found a statistically significant negative relationship between levels of MCP-1 and working memory, attention and verbal memory. At higher levels of chemokines, worse cognitive functioning in these areas.Verbal memory was also negatively related, in a meaningful way, with nitric oxide levels in blood.Likewise, we found that higher levels of glutathione correlated with better scores on the 3 tests performed of verbal fluency.ConclusionsIn patients with a PEP, levels of certain markers of oxidative stress and inflammation are associated with poorer cognitive functioning.

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