Multiple Organ Dysfunction Syndrome in Children With Sepsis: Role of Genetic Factors

2008 ◽  
Vol 28 (5) ◽  
pp. 499-509 ◽  
Author(s):  
Orfeas Liangos ◽  
Bertrand L. Jaber
Keyword(s):  
Organ Dysfunction ◽  
Multiple Organ Dysfunction Syndrome ◽  
Genetic Factors ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction

scholarly journals Role of Damage-Associated Molecular Patterns and Uncontrolled Inflammation in Pediatric Sepsis-Induced Multiple Organ Dysfunction Syndrome

2018 ◽  
Vol 08 (01) ◽  
pp. 025-031 ◽  
Author(s):  
Diana Pang ◽  
Dalia Bashir ◽  
Joseph Carcillo ◽  
Trung Nguyen ◽  
Rajesh Aneja ◽  
...  
Keyword(s):  
Organ Dysfunction ◽  
Multiple Organ Dysfunction Syndrome ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Risk Of Death ◽  
Pediatric Sepsis ◽  
Molecular Patterns ◽  
Damage Associated Molecular Patterns ◽  
Stimulation Of

AbstractThe incidence of multiple organ dysfunction syndrome (MODS) in sepsis varies from 17 to 73% and furthermore, increases the risk of death by 60% when controlled for the number of dysfunctional organs. Several MODS phenotypes exist, each unique in presentation and pathophysiology. Common to the phenotypes is the stimulation of the immune response by pathogen-associated molecular patterns (PAMPs), or danger-associated molecular patterns (DAMPs) causing an unremitting inflammation. Two of the MODS phenotypes are discussed in detail, thrombocytopenia-associated multiple organ failure (TAMOF) and the hyperinflammatory phenotype–macrophage activating syndrome (MAS) and hemophagocytic lymphohistiocytosis (HLH). In the end, we will briefly review the role of mitochondrial dysfunction as a significant contributor to the pathogenesis of MODS.

Impaired chemoreflex sensitivity in adult patients with multiple organ dysfunction syndrome?the potential role of disease severity

2004 ◽  
Vol 30 (4) ◽  
pp. 665-672 ◽  
Author(s):  
Hendrik Schmidt ◽  
Ursula M�ller-Werdan ◽  
Sebastian Nuding ◽  
Thomas Hoffmann ◽  
Darrel P. Francis ◽  
...  
Keyword(s):  
Disease Severity ◽  
Organ Dysfunction ◽  
Multiple Organ Dysfunction Syndrome ◽  
Potential Role ◽  
Multiple Organ ◽  
Adult Patients ◽  
Multiple Organ Dysfunction ◽  
Chemoreflex Sensitivity

A patient with severe hypercalcemia in multiple organ dysfunction syndrome: Role of elevated circulating 1α,25(OH)2vitamin D levels

2010 ◽  
Vol 25 (6) ◽  
pp. 1455-1459 ◽  
Author(s):  
Junichiro James Kazama ◽  
Takashi Yamamoto ◽  
Hiroshi Oya ◽  
Satoshi Yamamoto ◽  
Yoshinobu Sato ◽  
...  
Keyword(s):  
Organ Dysfunction ◽  
Multiple Organ Dysfunction Syndrome ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Severe Hypercalcemia
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