scholarly journals The potential role of pomegranate and its nano-formulations on cerebral neurons in aluminum chloride induced Alzheimer rat model

2020 ◽  
Vol 27 (7) ◽  
pp. 1710-1716
Author(s):  
Mohammed S. Almuhayawi ◽  
Wafaa S. Ramadan ◽  
Steve Harakeh ◽  
Soad K. Al Jaouni ◽  
Dhruba J. Bharali ◽  
...  
Keyword(s):  
Rat Model ◽  
Aluminum Chloride ◽  
Potential Role ◽  
Cerebral Neurons

Diabetes-induced impairment of macrophage cytokine release in a rat model: Potential role of serum lipids

Life Sciences ◽  
1998 ◽  
Vol 63 (13) ◽  
pp. 1127-1136 ◽  
Author(s):  
Deborah L. Doxey ◽  
Salvador Nares ◽  
Bina Park ◽  
Chi Trieu ◽  
Christopher W. Cutler ◽  
...  
Keyword(s):  
Rat Model ◽  
Serum Lipids ◽  
Potential Role ◽  
Model Potential ◽  
Cytokine Release ◽  
Macrophage Cytokine

scholarly journals The Potential Role of Naproxen in Promoting Rivastigmine Effect Against Aluminum Chloride-Induced Alzheimer-Like Model in Rats

2021 ◽  
Author(s):  
Raafat A. Abdel-Aal ◽  
Ola A. Hussein ◽  
Reham G. Elsaady ◽  
Lobna Abdelzaher
Keyword(s):  
Aluminum Chloride ◽  
Ache Activity ◽  
Cholinesterase Inhibitors ◽  
Caspase 3 ◽  
Potential Role ◽  
Neuroprotective Effect ◽  
The Elderly ◽  
Cellular Level ◽  
Ability To Act

Abstract Alzheimer’s disease (AD) is one of the leading causes of dependence and disability among the elderly worldwide. The traditional anti-Alzheimer medication, rivastigmine, one of the cholinesterase inhibitors (ChEIs), fails to achieve a definitive cure. Neuroinflammation plays a central role in AD pathogenesis. We tested the hypothesis that naproxen, a non-steroidal anti-inflammatory drug (NSAID), administration to the rivastigmine-treated aluminum chloride (AlCl3), Alzheimer's rat model, could provide an additive neuroprotective effect compared to rivastigmine alone. The studied groups were control (Cont), AlCl3 treated (Al), rivastigmine treated (RIVA), naproxen treated (Napro), and combined rivastigmine and naproxen treated (RIVA + Napro). Rats’ memory, spatial learning, and cognitive behavior were assessed followed by evaluation of hippocampal acetylcholinesterase (AChE) activity. Hippocampal and cerebellar histopathology were thoroughly examined. A marker of astroglial injury; glial fibrillary acidic protein (GFAP), the apoptosis maker; activated caspase-3 and the neuroepithelial stem cells marker; nestin expressions were immunohistochemically assayed. AD rats displayed significantly impaired memory and cognitive function, augmented hippocampal AChE activity, massive neurodegeneration associated with enhanced astrogliosis, apoptosis, and impaired neurogenesis. Rivastigmine, naproxen, and their combination decreased hippocampal AChE activity, mitigated behavioral and neuropathological changes in Al-intoxicated rats, possibly through downregulation of activated caspase-3 and upregulation of nestin. Except for the enhancement of neurogenesis and suppression of apoptosis, the combination therapy had no additional neuroprotective benefit over rivastigmine-only therapy. Naproxen's efficacy was demonstrated by its ability to act at the cellular level, enhance neurogenesis, and suppress apoptosis without having an additional mitigating impact in Al-induced cognitive impairment.

scholarly journals SUN-152 POTENTIAL ROLE OF INTERLEUKIN-11 IN A RAT MODEL OF MALIGNANT NEPHROSCLEROSIS

2019 ◽  
Vol 4 (7) ◽  
pp. S221
Author(s):  
K. HILGERS ◽  
C. Menendez-Castro ◽  
A. Ekici ◽  
N. Cordasic ◽  
A. Hartner
Keyword(s):  
Rat Model ◽  
Potential Role ◽  
Interleukin 11 ◽  
Malignant Nephrosclerosis

Sa1719 Potential Role of Acid Sensitive Ion Channels and 5-Hydroxytryptamine Receptors in a Rat Model of Refux Esophagitis

2016 ◽  
Vol 150 (4) ◽  
pp. S356
Author(s):  
Anastasia Shcherbakova ◽  
Heba Abdel-Aziz ◽  
Olaf Kelber ◽  
Gudrun Ulrich-Merzenich
Keyword(s):  
Ion Channels ◽  
Rat Model ◽  
Potential Role ◽  
Hydroxytryptamine Receptors
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