Understanding the role of scars in adults' narratives of childhood liver transplantation: A sociological perspective

Liver transplantation is considered an effective therapeutic option for Wilson’s disease (WD) patients with hepatic phenotype, since it removes the inherited defects of copper metabolism, and is associated with excellent graft and patient outcomes. The role of liver transplantation in WD patients with mixed hepatic and neuropsychiatric phenotype has remained controversial over time, mainly because of high post-operative complications, reduced survival and a variable, unpredictable rate of neurological improvement. This article critically discusses the recently published data in this field, focussing in more detail on isolated neuropsychiatric phenotype as a potential indication for liver transplantation in WD patients.

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Target Therapies for NASH/NAFLD: From the Molecular Aspect to the Pharmacological and Surgical Alternatives

Journal of Personalized Medicine ◽

10.3390/jpm11060499 ◽

2021 ◽

Vol 11 (6) ◽

pp. 499

Author(s):

Michele Finotti ◽

Maurizio Romano ◽

Pasquale Auricchio ◽

Michele Scopelliti ◽

Marco Brizzolari ◽

...

Keyword(s):

Liver Transplantation ◽

Fatty Liver Disease ◽

Hepatic Disease ◽

Lifestyle Modifications ◽

Alcoholic Fatty Liver ◽

Target Therapies ◽

Chronic Hepatic Disease ◽

The Impact ◽

Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease represents an increasing cause of chronic hepatic disease in recent years. This condition usually arises in patients with multiple comorbidities, the so-called metabolic syndrome. The therapeutic options are multiple, ranging from lifestyle modifications, pharmacological options, to liver transplantation in selected cases. The choice of the most beneficial one and their interactions can be challenging. It is mandatory to stratify the patients according to the severity of their disease to tailor the available treatments. In our contribution, we review the most recent pharmacological target therapies, the role of bariatric surgery, and the impact of liver transplantation on the NAFLD outcome.

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The Role of Liver Transplantation in the Management of Paediatric Liver Tumours

Annals of The Royal College of Surgeons of England ◽

10.1308/003588407x155527 ◽

2007 ◽

Vol 89 (1) ◽

pp. 12-21 ◽

Cited By ~ 33

Author(s):

Mark D Stringer

Keyword(s):

Liver Transplantation ◽

Hepatocellular Cancer ◽

Good Prognosis ◽

Liver Tumours ◽

Primary Hepatic Malignancies ◽

Life Saving ◽

Time Of Presentation ◽

Benign Liver ◽

Hepatic Malignancies

In recent years, considerable progress has been made in the treatment of children with hepatoblastoma largely due to effective pre-operative chemotherapy. Total hepatectomy and liver transplantation has emerged as an effective treatment for the small proportion of children with unresectable hepatoblastoma limited to the liver. A 5-year survival of 70% can be achieved in such cases. In contrast, the results of liver transplantation in children with hepatocellular cancer remain poor because these tumours are usually advanced with evidence of major vascular invasion and/or extrahepatic spread at the time of presentation. An exception is those children in whom the hepatocellular carcinoma is detected during surveillance of chronic liver disease – they typically have smaller tumours and frequently have a good prognosis after liver transplantation. The role of liver transplantation in children with other primary hepatic malignancies remains uncertain because experience is very limited. Liver transplantation is rarely needed in the management of children with benign liver tumours but, if other treatments have failed, it can be a life-saving intervention.

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