Coprecipitation of hydrochlorothiazide/PVP for the dissolution rate improvement by precipitation with compressed fluid antisolvent process

2017 ◽  
Vol 126 ◽  
pp. 37-46 ◽  
Author(s):  
Hee Jeong Park ◽  
Tae Jun Yoon ◽  
Dong Eui Kwon ◽  
Kyungseok Yu ◽  
Youn-Woo Lee
Keyword(s):  
Dissolution Rate ◽  
Rate Improvement ◽  
Compressed Fluid

Fusion as an Approach to Enhance Dissolution Rate of a Poorly Water-Soluble Drug (Curcurmin)

2011 ◽  
Vol 393-395 ◽  
pp. 119-122
Author(s):  
Dong Hua Wan ◽  
Fen Lin ◽  
Qu Xiang Liao
Keyword(s):  
Dissolution Rate ◽  
Drug Loading ◽  
Solid Dispersions ◽  
Gastric Fluid ◽  
Molecular State ◽  
Water Soluble ◽  
Drug Dissolution ◽  
Simulated Gastric Fluid ◽  
Scanning Calorimetry ◽  
Rate Improvement

It’s well known that curcumin is practically insoluble in water. Therefore, to improve the drug dissolution rate, fusion approach was employed to prepare curcumin solid dispersions (SDs) in the carrier Pluronic F68 with three different drug loads. The dissolution rate of curcumin from the SDs was measured at simulated gastric fluid. The concentration of the dissolved drug in the medium was determined by HPLC. The dissolution rates of the formulations were dependent on the drug loading in SDs. 92.2% CUR was dissolved in 10 min from the SDs with 8.97% drug load, whereas the amounts of drug released were 65.8% and 84.2% within 120 min from the SDs with 18.9% and 29.0% drug loads, respectively. The Fourier transform infrared spectra indicated hydrogen bond between the drug and carrier. Furthermore, their physicochemical properties were well investigated using differential scanning calorimetry and X-ray diffraction. In the dispersions containing 8.97% CUR, the drug was in the molecular state. At a composition of approximately 18.9%, CUR was dispersed as micro-fine crystals. These interesting results indicate that the physical states of the drug in the carrier, which are governed by the drug loading, can affect the dissolution rate improvement.

Griseofulvin micronization and dissolution rate improvement by supercritical assisted atomization

2004 ◽  
Vol 56 (11) ◽  
pp. 1379-1387 ◽  
Author(s):  
E. Reverchon ◽  
G. Della Porta ◽  
A. Spada ◽  
A. Antonacci
Keyword(s):  
Dissolution Rate ◽  
Rate Improvement

scholarly journals Surface Stabilization and Dissolution Rate Improvement of Amorphous Compacts with Thin Polymer Coatings: Can We Have It All?

2020 ◽  
Vol 17 (4) ◽  
pp. 1248-1260 ◽  
Author(s):  
Dunja Novakovic ◽  
Leena Peltonen ◽  
Antti Isomäki ◽  
Sara J. Fraser-Miller ◽  
Line Hagner Nielsen ◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Polymer Coatings ◽  
Surface Stabilization ◽  
Thin Polymer ◽  
Rate Improvement

Hot Melt Extrudates Formulated Using Design Space: One Simple Process for Both Palatability and Dissolution Rate Improvement

2018 ◽  
Vol 107 (1) ◽  
pp. 286-296 ◽  
Author(s):  
Lorena F.B. Malaquias ◽  
Heidi L. Schulte ◽  
Juliano A. Chaker ◽  
Kapish Karan ◽  
Thomas Durig ◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Design Space ◽  
Simple Process ◽  
Rate Improvement ◽  
Hot Melt

Ternary solid dispersion to improve solubility and dissolution of meloxicam

2019 ◽  
Vol 30 (6) ◽  
Author(s):  
Dwi Setyawan ◽  
Meivita Yusmala Dewi ◽  
Dewi Isadiartuti
Keyword(s):  
Hydrogen Bonding ◽  
Dissolution Rate ◽  
Solid Dispersion ◽  
Methyl Cellulose ◽  
Water Soluble ◽  
Dissolution Profile ◽  
Polymer Carrier ◽  
Hydrogen Bonding Interactions ◽  
Rate Improvement ◽  
Evaporation Technique

Abstract Background Meloxicam (MLX) is a potent non-steroidal anti-inflammatory drug with poor solubility. Solid dispersion (SD) is an effective formulation strategy to improve the dissolution rate of poorly water-soluble compounds. Hydroxy propyl methyl cellulose (HPMC) as an inert polymer carrier and nicotinic acid (NA) as disturbance can be used as a matrix of SD. The aim of this study was to determine the effect of MLX-HPMC-NA SD on the solubility and dissolution of MLX. Methods SD was prepared by the solvent evaporation technique with methanol being used as a solvent. Methanol was evaporated at room temperature. SD of MLX was prepared involving various matrix compositions at MLX:HPMC:NA ratios of 1:1:1 (SD1), 1:1:2 (SD2), 1:2:1 (SD3), and 1:2:2 (SD4). Results The solubility profile of MLX in SD3 (64.34 ppm) showed a higher improvement than the physical mixture (15.99 ppm) and pure MLX (6.89 ppm). This increase might be due to the formation of molecular dispersion of MLX in the polymer as hydrophilic matrix and NA have both donor-acceptor sites for hydrogen bonding interactions. The dissolution profile of SD3 also showed the highest improvement. The melting endotherm of SD3 was detected at 219.5 °C, in which case it originated from NA rather than from MLX, showing that MLX was molecularly dispersed and amorphous. Conclusions MLX solubility and dissolution profile could be improved by the SD technique with a matrix of HPMC and NA. The best result was given by SD3 with an MLX:HPMC:NA ratio of 1:2:1. Based on the characterization study, it is predicted that hydrophilic polymer and hydrogen bonding interactions play important roles in MLX solubility or dissolution rate improvement.

Dissolution rate improvement of valsartan by low temperature recrystallization in compressed CO2: Prevention of excessive agglomeration

2011 ◽  
Vol 59 ◽  
pp. 117-123 ◽  
Author(s):  
Yong-Suk Youn ◽  
Jin Hee Oh ◽  
Ki Ho Ahn ◽  
Minsoo Kim ◽  
Jaehoon Kim ◽  
...  
Keyword(s):  
Low Temperature ◽  
Dissolution Rate ◽  
Rate Improvement
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