A simple strategy to prepare hybrid coating on titanium (Ti6Al4V)

The rational design of conformationally controlled foldable modules can lead to a deeper insight into the conformational space of complex biological molecules where non-covalent interactions such as hydrogen bonding and π-stacking are known to play a pivotal role. Squaramides are known to have excellent hydrogen bonding capabilities and hence, are ideal molecules for designing foldable modules that can mimic the secondary structures of bio-molecules. The π-stacking induced folding of bis-squaraines tethered using aliphatic primary and secondary-diamine linkers of varying length is explored with a simple strategy of invoking small perturbations involving the length linkers and degree of substitution. Solution phase NMR investigations in combination with molecular dynamics simulations suggest that bis-squaraines predominantly exist as extended conformations. Structures elucidated by X-ray crystallography confirmed a variety of folded and extended secondary conformations including hairpin turns and 𝛽-sheets which are determined by the hierarchy of π-stacking relative to N–H···O hydrogen bonds.

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Hierarchy of π-Stacking Determines the Conformational Preference of Bis-Squaraines

10.26434/chemrxiv.13041830 ◽

2020 ◽

Author(s):

Abhishek Singh ◽

Reman K. Singh ◽

G Naresh Patwari

Keyword(s):

Hydrogen Bonding ◽

Rational Design ◽

Biological Molecules ◽

Conformational Space ◽

X Ray Crystallography ◽

Simple Strategy ◽

Induced Folding ◽

Π Stacking ◽

Varying Length ◽

Dynamics Simulations

The rational design of conformationally controlled foldable modules can lead to a deeper insight into the conformational space of complex biological molecules where non-covalent interactions such as hydrogen bonding and π-stacking are known to play a pivotal role. Squaramides are known to have excellent hydrogen bonding capabilities and hence, are ideal molecules for designing foldable modules that can mimic the secondary structures of bio-molecules. The π-stacking induced folding of bis-squaraines tethered using aliphatic primary and secondary-diamine linkers of varying length is explored with a simple strategy of invoking small perturbations involving the length linkers and degree of substitution. Solution phase NMR investigations in combination with molecular dynamics simulations suggest that bis-squaraines predominantly exist as extended conformations. Structures elucidated by X-ray crystallography confirmed a variety of folded and extended secondary conformations including hairpin turns and 𝛽-sheets which are determined by the hierarchy of π-stacking relative to N–H···O hydrogen bonds.

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Revealing changes in curcumin bioavailability using vitamin C as an enhancer by HPLC-MS/MS

Current Pharmaceutical Analysis ◽

10.2174/1573412916666191220150039 ◽

2019 ◽

Vol 16 ◽

Author(s):

Xufen Dai ◽

Jiaxue Hao ◽

Ying Feng ◽

Jing Wang ◽

Qiannan Li ◽

...

Keyword(s):

Vitamin C ◽

High Performance ◽

Internal Standard ◽

Fold Increase ◽

Rat Plasma ◽

Pharmacokinetic Parameters ◽

Solution Ph ◽

Esi Ms ◽

Simple Strategy ◽

Isolated Compound

Background: Curcumin (CUR), a natural isolated compound from turmeric, has been the promising star in fighting many diseases but the broad application of curcumin has been limited ascribed to low bioavailability. Objective: The aim of this study is to pursue the enhancement of curcumin bioavailability through co-administration of vitamin C. Methods: Such purpose was achieved through the analysis of curcumin pharmacokinetics by high performance liquid chromatography coupled with electrospray ionization - tandem mass spectrometry (HPLC - ESI - MS/MS). The plasma was separated on a C18 reverse phase column using acetonitrile and ammonium formate solution (pH 6.5; 2.0 mM) at 0.8 mL/min. MS/MS detection was carried out in negative mode using mass patterns of m/z 367.0 > 216.7 for curcumin and m/z 265.2 > 223.9 for internal standard (honokiol). Results: Successful application of the proposed method in the pharmacokinetic study presented clear changes in key pharmacokinetic parameters including the growth of AUC (0-t) up to 2.4 times, 2.2-fold increase of Cmax, 2.2-fold loss of CL, and 1.5-fold diminishment of t1/2. Conclusion: We developed an HPLC-ESI-MS/MS method for determination of curcumin in rat plasma and validated the improvement of bioavailability of curcumin through co-administration of vitamin C. We reasoned these changes to the inhibition of lipid peroxidation induced by the use of vitamin C. Such a simple strategy is possible to become an alternative for enhancing curcumin efficiency in practice.

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A simple strategy increases mothers’ knowledge of breastfeeding and improves the breastfeeding rates

Jornal de Pediatria ◽

10.2223/jped.457 ◽

1998 ◽

Vol 74 (5) ◽

pp. 368-76 ◽

Cited By ~ 2

Author(s):

Lulie R.O. Susin ◽

Elsa R. J. Giugliani ◽

Suzane C. Kummer ◽

Marileide Maciel ◽

Ana C. W. Benjamin ◽

...

Keyword(s):

Simple Strategy ◽

Breastfeeding Rates

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A simple strategy based on photobiotin irradiation for the photoelectrochemical immobilization of proteins on electrode surfaces

Materials Science and Engineering C ◽

10.1016/j.msec.2005.10.076 ◽

2006 ◽

Vol 26 (2-3) ◽

pp. 436-441 ◽

Cited By ~ 5

Author(s):

Serge Cosnier ◽

Carmen Molins ◽

Christine Mousty ◽

Bruno Galland ◽

Arielle Lepellec

Keyword(s):

Electrode Surfaces ◽

Simple Strategy

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A Novel Quinoxaline-Rhodamine Conjugate for a Simple and Efficient Detection of Hydrogen Sulphate Ion

Compounds ◽

10.3390/compounds1010004 ◽

2021 ◽

Vol 1 (1) ◽

pp. 29-40

Author(s):

Sutapa Sahu ◽

Yeasin Sikdar ◽

Riya Bag ◽

Dilip K. Maiti ◽

José P. Cerón-Carrasco ◽

...

Keyword(s):

Solid Phase ◽

Detection Limits ◽

Hydrogen Sulfate ◽

Absorption And Emission ◽

Conjugate System ◽

Colorimetric Chemosensor ◽

Simple Strategy ◽

Efficient Detection ◽

Hydrogen Sulphate

This work presents the development of a quinoxaline and rhodamine conjugate system that acts as a colorimetric chemosensor for hydrogen sulfate (HSO4−) ions in methanol media. This sensor has been characterized both theoretically and experimentally. The detection limits for HSO4− are small as 0.71 µM and 3.8 µM for the absorption and emission experiments, respectively. The effectiveness of the probe in recognizing HSO4− both in gel and solid phase is evaluated as well. Thus, this works presents a simple strategy to detect the environmental HSO4− pollutant event at tiny concentrations.

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Nonisocyanate Poly(Hydroxyl Urethane)-Based Green Polymer Hybrid Coating Systems: Tailoring of Biomacromolecular Compound Architecture Using APTMS-ZnO/TEMPO-Oxidized Cellulose Nanoparticles

ACS Omega ◽

10.1021/acsomega.9b04388 ◽

2020 ◽

Vol 5 (18) ◽

pp. 10315-10326 ◽

Cited By ~ 1

Author(s):

Mhd. Abd. Cader Mhd. Haniffa ◽

Hazlee Azil Illias ◽

Ching Yern Chee ◽

Shaliza Ibrahim ◽

Viorel Sandu ◽

...

Keyword(s):

Hybrid Coating ◽

Oxidized Cellulose ◽

Cellulose Nanoparticles ◽

Polymer Hybrid ◽

Green Polymer

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Cyclometalated iridium–BODIPY ratiometric O2 sensors

Chemical Science ◽

10.1039/c9sc00696f ◽

2019 ◽

Vol 10 (19) ◽

pp. 5124-5132 ◽

Cited By ~ 11

Author(s):

Ku Sun Choung ◽

Karen Marroquin ◽

Thomas S. Teets

Keyword(s):

Molecular Oxygen ◽

Simple Strategy ◽

Ratiometric Sensors

Cyclometalated iridium–BODIPY conjugates are prepared by a simple strategy and are effective ratiometric sensors for molecular oxygen.

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-ADIC -FUNCTIONS FOR ORDINARY FAMILIES ON SYMPLECTIC GROUPS

Journal of the Institute of Mathematics of Jussieu ◽

10.1017/s1474748018000415 ◽

2019 ◽

Vol 19 (4) ◽

pp. 1287-1347 ◽

Cited By ~ 2

Author(s):

Zheng Liu

Keyword(s):

Eisenstein Series ◽

Symplectic Group ◽

Symplectic Groups ◽

Simple Strategy ◽

Doubling Method

We construct the $p$-adic standard $L$-functions for ordinary families of Hecke eigensystems of the symplectic group $\operatorname{Sp}(2n)_{/\mathbb{Q}}$ using the doubling method. We explain a clear and simple strategy of choosing the local sections for the Siegel Eisenstein series on the doubling group $\operatorname{Sp}(4n)_{/\mathbb{Q}}$, which guarantees the nonvanishing of local zeta integrals and allows us to $p$-adically interpolate the restrictions of the Siegel Eisenstein series to $\operatorname{Sp}(2n)_{/\mathbb{Q}}\times \operatorname{Sp}(2n)_{/\mathbb{Q}}$.

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