Prognostic relevance of lymph node ratio and total lymph node count for small bowel adenocarcinoma

Surgery ◽  
2015 ◽  
Vol 158 (2) ◽  
pp. 486-493 ◽  
Author(s):  
Thuy B. Tran ◽  
Motaz Qadan ◽  
Monica M. Dua ◽  
Jeffrey A. Norton ◽  
George A. Poultsides ◽  
...  
2018 ◽  
Vol 18 (6) ◽  
pp. e1293-e1310
Author(s):  
Fatma Abd-Elshahed Abd-Elhay ◽  
Khaled Mosaad Elhusseiny ◽  
Mohamed Gomaa Kamel ◽  
Soon Khai Low ◽  
To Kim Sang ◽  
...  

Cancers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 762
Author(s):  
Yunghun You ◽  
Yong Chan Shin ◽  
Dong Wook Choi ◽  
Jin Seok Heo ◽  
Sang Hyun Shin ◽  
...  

The 8th American Joint Committee on Cancer (AJCC) staging system for distal cholangiocarcinoma (DCC) included a positive lymph node count (PLNC), but a comparison of the prognostic predictive power of PLNC and lymph node ratio (LNR) is still under debate. This study aimed to compare various staging models made by combining the abovementioned factors, identify the model with the best predictive power, and propose a modified staging system. We retrospectively reviewed 251 patients who underwent surgery for DCC at four centers. To determine the superiority of various staging models for predicting overall OSR, Akaike information criterion (AIC), Bayesian information criterion (BIC), AIC correction (AICc), and Harrell’s C-statistic were calculated. In multivariate analysis, age (p = 0.003), total lymph node count (p = 0.033), and revised T(LNR)M staging (p < 0.001) were identified as independent factors for overall survival rate. The predictive performance of revised T (LNR) M staging (AIC: 1288.925, BIC: 1303.377, AICc: 1291.52, and Harrell’s C statics: 0.667) was superior to other staging system. A modified staging system consisting of revised T category and LNR predicted better overall survival of DCC than AJCC 7th and AJCC 8th editions. In the future, external validation of the proposed new system using a larger cohort will be required.


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