Training in soft tissue resection using real-time visual computer navigation feedback from the Surgery Tutor: A randomized controlled trial

Surgery ◽  
2021 ◽  
Author(s):  
Meredith Poole ◽  
Tamas Ungi ◽  
Gabor Fichtinger ◽  
Boris Zevin
Keyword(s):  
Randomized Controlled Trial ◽  
Soft Tissue ◽  
Real Time ◽  
Controlled Trial ◽  
Computer Navigation ◽  
Randomized Controlled ◽  
Visual Computer

Efficacy of Real-Time Computer-Aided Detection of Colorectal Neoplasia in a Non-Expert Setting: A Randomized Controlled Trial

2021 ◽  
Author(s):  
A Repici ◽  
M Spadaccini ◽  
G Antonelli ◽  
R Maselli ◽  
PA Galtieri ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Real Time ◽  
Colorectal Neoplasia ◽  
Controlled Trial ◽  
Computer Aided Detection ◽  
Randomized Controlled ◽  
Computer Aided

scholarly journals Testing a Real-Time Tenofovir Urine Adherence Assay for Monitoring and Providing Feedback to Preexposure Prophylaxis in Kenya (PUMA): Protocol for a Pilot Randomized Controlled Trial (Preprint)

2019 ◽  
Author(s):  
Paul Drain ◽  
Kenneth Ngure ◽  
Nelly Mugo ◽  
Matthew Spinelli ◽  
Purba Chatterjee ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Real Time ◽  
Point Of Care ◽  
Controlled Trial ◽  
Standard Of Care ◽  
Randomized Controlled ◽  
Preexposure Prophylaxis ◽  
Adherence Monitoring ◽  
First Time

BACKGROUND The worldwide expansion of preexposure prophylaxis (PrEP) with oral tenofovir-disoproxil-fumarate/emtricitabine will be critical to ending the HIV epidemic. However, maintaining daily adherence to PrEP can be difficult, and the accuracy of self-reported adherence is often limited by social desirability bias. Pharmacologic adherence monitoring (measuring drug levels in a biomatrix) has been critical to interpreting PrEP trials, but testing usually requires expensive equipment and skilled personnel. We have recently developed a point-of-care (POC) immunoassay to measure tenofovir in urine, allowing real-time adherence monitoring for the first time. OBJECTIVE The goal of this study is to examine a point-of-care adherence metric in PrEP to support and increase adherence via a randomized controlled trial. METHODS The paper describes the protocol for a pilot randomized controlled trial to test the acceptability, feasibility, and impact on long-term adherence of implementing a POC urine test to provide real-time adherence feedback among women on PrEP. Eligible women (n=100) will be HIV-negative, ≥18 years old, and recruited from a clinic in Kenya that provides PrEP. Participants will be randomized 1:1 to the intervention of providing real-time feedback via the assay versus standard of care adherence counseling. Acceptability by participants will be assessed by a quantitative survey, as well as by qualitative data collected via in-depth interviews (n=20) and focus group discussions (n=4 groups, 5-10 women each). Feasibility will be assessed by the proportion of women retained in the study, the mean number of missed visits, the proportion of planned urine assessments completed, and messages delivered, while in-depth interviews with providers (n=8) will explore the ease of administering the urine test. Tenofovir levels in hair will serve as long-term adherence metrics. A linear mixed-effects model will estimate the effect of the intervention versus standard of care on logarithmically transformed levels of tenofovir in hair. RESULTS This study has been funded by the National Institute of Health, approved by the Kenya Medical Research Institute Institutional Review Board, and will commence in June 2020. CONCLUSIONS A novel urine assay to measure and deliver information on adherence to PrEP in real-time will be tested for the first time in this trial planned among women on PrEP in Kenya. Study findings will inform a larger-scale trial assessing the impact of real-time adherence monitoring/feedback on HIV prevention. Improving adherence to PrEP will have long-term implications for efforts to end the HIV epidemic worldwide. CLINICALTRIAL ClinicalTrials.gov NCT03935464; https://clinicaltrials.gov/ct2/show/NCT03935464 INTERNATIONAL REGISTERED REPORT PRR1-10.2196/15029

Developing a Real-Time Electroencephalogram-Guided Anesthesia-Management Curriculum for Educating Residents: A Single-Center Randomized Controlled Trial

2021 ◽  
Vol 134 (1) ◽  
pp. 159-170
Author(s):  
Miles Berger ◽  
Sarada S. Eleswarpu ◽  
Mary Cooter Wright ◽  
Anna M. Ray ◽  
Sarah A. Wingfield ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Real Time ◽  
Controlled Trial ◽  
Single Center ◽  
Anesthesia Management ◽  
Randomized Controlled ◽  
Management Curriculum

Soft tissue expander for vertically atrophied alveolar ridges: Prospective, multicenter, randomized controlled trial

2020 ◽  
Vol 31 (7) ◽  
pp. 585-594 ◽  
Author(s):  
Soo‐Hwan Byun ◽  
Seon‐Yeong Kim ◽  
Ho Lee ◽  
Ho‐Kyung Lim ◽  
Ju‐Won Kim ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Soft Tissue ◽  
Controlled Trial ◽  
Tissue Expander ◽  
Randomized Controlled ◽  
Multicenter Randomized Controlled Trial

scholarly journals A randomized controlled trial of plasma real-time PCR and antigenemia assay for monitoring CMV infection after unrelated BMT

2009 ◽  
Vol 45 (8) ◽  
pp. 1325-1332 ◽  
Author(s):  
Y Kanda ◽  
T Yamashita ◽  
T Mori ◽  
T Ito ◽  
K Tajika ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Real Time ◽  
Real Time Pcr ◽  
Controlled Trial ◽  
Cmv Infection ◽  
Randomized Controlled ◽  
Antigenemia Assay

scholarly journals Real-time optimized biofeedback utilizing sport techniques (ROBUST): a study protocol for a randomized controlled trial

2017 ◽  
Vol 18 (1) ◽  
Author(s):  
Jeffrey B. Taylor ◽  
Anh-Dung Nguyen ◽  
Mark V. Paterno ◽  
Bin Huang ◽  
Kevin R. Ford
Keyword(s):  
Randomized Controlled Trial ◽  
Real Time ◽  
Study Protocol ◽  
Controlled Trial ◽  
Randomized Controlled
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